ZnSO4 Protects against premature ovarian failure through PI3K/AKT/GSK3β signaling pathway

Dong, Zhaoqi; Zhang, Lu; Wang, Wei; Jiang, Fan; Ai, Hao

doi:10.1016/j.theriogenology.2023.05.023

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…This may be correlated with the reduction in Zinc (Zn) observed after Cisplatin treatment, which acts as an antioxidant by promoting the activation of Akt. The activated Akt is capable of entering mitochondria and phosphorylate GSK3β, whose inhibition restricts ROS levels [ 99 ].…”

Section: Pi3k/akt Pathway In Reproductive Pathologiesmentioning

confidence: 99%

An Update on Physiopathological Roles of Akt in the ReprodAKTive Mammalian Ovary

Giaccari,

Antonouli,

Anifandis

et al. 2024

Life

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The phosphoinositide 3-kinase (PI3K)/Akt pathway is a key signaling cascade responsible for the regulation of cell survival, proliferation, and metabolism in the ovarian microenvironment. The optimal finetuning of this pathway is essential for physiological processes concerning oogenesis, folliculogenesis, oocyte maturation, and embryo development. The dysregulation of PI3K/Akt can impair molecular and structural mechanisms that will lead to follicle atresia, or the inability of embryos to reach later stages of development. Due to its pivotal role in the control of cell proliferation, apoptosis, and survival mechanisms, the dysregulation of this molecular pathway can trigger the onset of pathological conditions. Among these, we will focus on diseases that can harm female fertility, such as polycystic ovary syndrome and premature ovarian failure, or women’s general health, such as ovarian cancer. In this review, we report the functions of the PI3K/Akt pathway in both its physiological and pathological roles, and we address the existing application of inhibitors and activators for the balancing of the molecular cascade in ovarian pathological environments.

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Section: Pi3k/akt Pathway In Reproductive Pathologiesmentioning

confidence: 99%