ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect

Кузнецова, Вера; Орлова, А. О.; Kanaev, Pavel; Gromova, Yulia; Маслов, В. Г.; Баранов, А. А.; Fedorov, Anatoly V.

doi:10.1117/12.2052528

Cited by 8 publications

(11 citation statements)

References 30 publications

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“…A coulomb electrostatic interaction of the oppositely charged cysteine capping AIS QDs and cyanine molecules results in the formation QD/dye complexes. Similar principle of complex formation was utilized in [ 36 , 37 , 38 ]. To examine the FRET effect, the PL intensities of QDs and dyes have been analyzed as a function of the ratio of the QD/dye concentration in the mixture solution.…”

Section: Methodsmentioning

confidence: 99%

Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

et al. 2020

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Nowadays, multiplex analysis is very popular, since it allows to detect a large number of biomarkers simultaneously. Traditional multiplex analysis is usually based on changes of photoluminescence (PL) intensity and/or PL band spectral positions in the presence of analytes. Using PL lifetime as an additional parameter might increase the efficiency of multiplex methods. Quantum dots (QDs) can be used as luminescent markers for multiplex analysis. Ternary in-based QDs are a great alternative to the traditional Cd-based one. Ternary QDs possess all advantages of traditional QDs, including tunable photoluminescence in visible range. At the same time ternary QDs do not have Cd-toxicity, and moreover they possess long spectral dependent lifetimes. This allows the use of ternary QDs as a donor for time-resolved multiplex sensing based on Förster resonance energy transfer (FRET). In the present work, we implemented FRET from AgInS2/ZnS ternary QDs to cyanine dyes absorbing in different spectral regions of QD luminescence with different lifetimes. As the result, FRET-induced luminescence of dyes differed not only in wavelengths but also in lifetimes of luminescence, which can be used for time-resolved multiplex analysis in biology and medicine.

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Section: Methodsmentioning

confidence: 99%

Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

et al. 2020

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“…A detailed description of the calculations can be found in Ref. [13]. As seen from Table 1, for both systems the distance between QDs and Ce6 does not exceed 10 nm.…”

Section: Resonance Conditions In Qd/ce6 Complexesmentioning

confidence: 97%

“…Along with that this class of organic dyes has the ability to be selectively accumulated in tumor cells [13], making their usage attractive for diagnostics and photodynamic cancer therapy (PDT). Chlorin e6 (Ce6) is a brilliant representative of tetrapyrrole molecules, and it is the main component of many drugs for photodynamic cancer therapy [2] including drug "Photoditazin" TM .…”

Section: Introductionmentioning

confidence: 99%

Energy transfer efficiency in quantum dot/chlorin e6 complexes

et al. 2015

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New biocompatible complexes based on manganese-doped core/shell ZnS/ZnS quantum dots (ZnS:Mn 2+ /ZnS) and drug "Photoditazin" were formed and compared to traditional complexes with CdSe/ZnS quantum dots. Complexes with ZnS:Mn/ZnS quantum dots show some advantages in their photophysical properties. At the same time they demonstrate evident difference in their photophysical properties that may be associated with various location of trap states in places where drug molecule bounds with quantum dot.

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“…It was shown that the fluorophore's long lifetimes lead to a considerable suppression of the autofluorescence background and, consequently, to the overall sensitivity improvement [29]. Broad bandwidths and long lifetimes of ternary QDs are also beneficial for the applications with Förster resonance energy transfer (FRET), where QDs can be utilized as efficient energy donors [30][31][32][33]. In this case, the donor−acceptor pairs with acceptor absorption bands overlapping QD PL at different wavelengths and lifetimes result in different lifetimes of sensitized dye PL that allow for spectral and lifetime multiplexing [30,31,34].…”

Section: Introductionmentioning

confidence: 99%

Lab-on-Microsphere—FRET-Based Multiplex Sensor Platform

et al. 2021

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Here we report on the development and investigation of a novel multiplex assay model based on polymer microspheres (PMS) encoded with ternary AIS/ZnS quantum dots (QDs). The system was prepared via layer-by-layer deposition technique. Our studies of Förster resonance energy transfer (FRET) between the QD-encoded microspheres and two different cyanine dyes have demonstrated that the QD photoluminescence (PL) quenching steadily increases with a decrease in the QD-dye distance. We have found that the sensitized dye PL intensity demonstrates a clear maximum at two double layers of polyelectrolytes between QDs and Dye molecules on the polymer microspheres. Time resolved PL measurements have shown that the PL lifetime decreases for the QDs and increases for the dyes due to FRET. The designed system makes it possible to record spectrally different bands of FRET-induced dye luminescence with different decay times and thereby allows for the multiplexing by wavelength and photoluminescence lifetimes of the dyes. We believe that PMS encoded with AIS/ZnS QDs have great potential for the development of new highly selective and sensitive sensor systems for multiplex analysis to detect cell lysates and body fluids’ representative biomarkers.

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ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect

Cited by 8 publications

References 30 publications

Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

Energy transfer efficiency in quantum dot/chlorin e6 complexes

Lab-on-Microsphere—FRET-Based Multiplex Sensor Platform

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