ZnSe nanodisks:Ti3C2 MXenes-modified electrode for nucleic acid liquid biopsy with photoelectrochemical strategy

Meng, Yuchan; Qin, Nana; Hun, Xu

doi:10.1007/s00604-021-05117-0

Cited by 11 publications

(5 citation statements)

References 45 publications

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“…The diffraction peaks of Ti 3 AlC 2 at 9.5 °, 19.06 °, 38.7 °, and 41.84 °matched well with the diffraction peaks of the standard card (JCPDS card number: 52-0875) (curve a in Figure 1D). The XRD results of the Ti 3 C 2 showed the disappearance of the 38.7 °diffraction peak in the Al (104) plane and the left shift of the diffraction peak in the (002) plane of Ti 3 C 2 from 9.5 °to 8.27 °, which indicated the successful preparation of Ti 3 C 2 (curve b in Figure 1D) (Ran et al, 2017;Alhabeb et al, 2018;Meng et al, 2021). When AuNPs are generated by in situ reduction on the surface of Ti 3 C 2 , curve c in Figure 1D shows that AuNPs@Ti 3 C 2 have the characteristic diffraction peaks of both Ti 3 C 2 and AuNPs (Yang et al, 2022).…”

Section: Resultsmentioning

confidence: 96%

In situ reduction of gold nanoparticles-decorated MXenes-based electrochemical sensing platform for KRAS gene detection

Bai

Wang

2023

Front. Bioeng. Biotechnol.

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In this work, gold nanoparticles@Ti3C2 MXenes nanocomposites with excellent properties were combined with toehold-mediated DNA strand displacement reaction to construct an electrochemical circulating tumor DNA biosensor. The gold nanoparticles were synthesized in situ on the surface of Ti3C2 MXenes as a reducing and stabilizing agent. The good electrical conductivity of the gold nanoparticles@Ti3C2 MXenes composite and the nucleic acid amplification strategy of enzyme-free toehold-mediated DNA strand displacement reaction can be used to efficiently and specifically detect the non-small cell cancer biomarker circulating tumor DNA KRAS gene. The biosensor has a linear detection range of 10 fM −10 nM and a detection limit of 0.38 fM, and also efficiently distinguishes single base mismatched DNA sequences. The biosensor has been successfully used for the sensitive detection of KRAS gene G12D, which has excellent potential for clinical analysis and provides a new idea for the preparation of novel MXenes-based two-dimensional composites and their application in electrochemical DNA biosensors.

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Section: Resultsmentioning

confidence: 96%

In situ reduction of gold nanoparticles-decorated MXenes-based electrochemical sensing platform for KRAS gene detection

Bai

Wang

2023

Front. Bioeng. Biotechnol.

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“…The diffraction peaks of Ti 3 C 2 T x agree with the PDF card No. 00-052-0875 with the hexagonal system of P 6 3 / mmc . However, the diffraction peaks of Ti 3 C 2 T x are shifted to a relatively lower position than the standard peaks.…”

Section: Resultsmentioning

confidence: 99%

Ga₂O₃–MXene Nanowire Networks with Enhanced Responsivity for Deep-UV Photodetection

et al. 2023

ACS Appl. Nano Mater.

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Ga 2 O 3 is a promising semiconductor for solar-blind (200−280 nm) photodetectors. Two-dimensional (2D) MXenes have been widely applied in the optoelectronic area owing to their high conductivity and large specific surface area. The few-layered Ti 3 C 2 T x (Ti 3 C 2 T x -few) exhibits elevated properties compared with multilayered Ti 3 C 2 T x . Herein, we innovatively adopt a hydrothermal method to prepare Ti 3 C 2 T x -few. A Ga 2 O 3 −Ti 3 C 2 T x 3D network heterojunction is fabricated by van der Waals interaction between one-dimensional (1D) nanowires and 2D nanosheets using the light trapping effect at the interface of the heterostructure. The van der Waals force between Ga 2 O 3 and Ti 3 C 2 T x -few enhances the contact for the transfer of photoelectrons. The optimal Ga 2 O 3 −5Ti 3 C 2 T x exhibits enhanced responsivity (140.57 mA W −1 ), defectivity (4.87 × 10 12 Jones), and external quantum efficiency (68.66%), which are 6.67, 3.20, and 6.68 times higher than that of pure Ga 2 O 3 nanowires under deepultraviolet light (254 nm). The improved properties of Ga 2 O 3 −xTi 3 C 2 T x heterostructure are attributed to the high conductivity of Ti 3 C 2 T x -few, enhanced separation of photogenerated electrons and holes, decreased Schottky barrier height, enlarged depletion region, increased UV light absorption, and enhanced contact via van der Waals force between Ga 2 O 3 and Ti 3 C 2 T x . In conclusion, the Ga 2 O 3 −Ti 3 C 2 T x heterojunction extends the application of Ti 3 C 2 T x -few and provides a new tactic to improve the performance of the Ga 2 O 3 -based photodetector.

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“…This material shows promise for applications in photoelectrochemical biosensors. Meng et al prepared the first ZnSe nanodisk:Ti 3 C 2 MXene complex combined with a toehold-mediated strand displacement reaction for the electrochemical detection of ctDNA 59 . The preparation of this new MXene-based composite opens a new avenue for research on photoelectrochemical biosensors.…”

Section: Electrochemical Sensingmentioning

confidence: 99%

Current research status of tumor cell biomarker detection

Jiang,

Lin,

Chen

et al. 2023

Microsyst Nanoeng

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With the annual increases in the morbidity and mortality rates of tumors, the use of biomarkers for early diagnosis and real-time monitoring of tumor cells is of great importance. Biomarkers used for tumor cell detection in body fluids include circulating tumor cells, nucleic acids, protein markers, and extracellular vesicles. Among them, circulating tumor cells, circulating tumor DNA, and exosomes have high potential for the prediction, diagnosis, and prognosis of tumor diseases due to the large amount of valuable information on tumor characteristics and evolution; in addition, in situ monitoring of telomerase and miRNA in living cells has been the topic of extensive research to understand tumor development in real time. Various techniques, such as enzyme-linked immunosorbent assays, immunoblotting, and mass spectrometry, have been widely used for the detection of these markers. Among them, the detection of tumor cell markers in body fluids based on electrochemical biosensors and fluorescence signal analysis is highly preferred because of its high sensitivity, rapid detection and portable operation. Herein, we summarize recent research progress in the detection of tumor cell biomarkers in body fluids using electrochemical and fluorescence biosensors, outline the current research status of in situ fluorescence monitoring and the analysis of tumor markers in living cells, and discuss the technical challenges for their practical clinical application to provide a reference for the development of new tumor marker detection methods.

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ZnSe nanodisks:Ti3C2 MXenes-modified electrode for nucleic acid liquid biopsy with photoelectrochemical strategy

Cited by 11 publications

References 45 publications

In situ reduction of gold nanoparticles-decorated MXenes-based electrochemical sensing platform for KRAS gene detection

In situ reduction of gold nanoparticles-decorated MXenes-based electrochemical sensing platform for KRAS gene detection

Ga₂O₃–MXene Nanowire Networks with Enhanced Responsivity for Deep-UV Photodetection

Current research status of tumor cell biomarker detection

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ZnSe nanodisks:Ti3C2 MXenes-modified electrode for nucleic acid liquid biopsy with photoelectrochemical strategy

Cited by 11 publications

References 45 publications

In situ reduction of gold nanoparticles-decorated MXenes-based electrochemical sensing platform for KRAS gene detection

In situ reduction of gold nanoparticles-decorated MXenes-based electrochemical sensing platform for KRAS gene detection

Ga2O3–MXene Nanowire Networks with Enhanced Responsivity for Deep-UV Photodetection

Current research status of tumor cell biomarker detection

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Ga₂O₃–MXene Nanowire Networks with Enhanced Responsivity for Deep-UV Photodetection