ZnS@BSA Nanoclusters Potentiate Efficacy of Cancer Immunotherapy (Adv. Mater. 49/2021)

Cen, Dong; Ge, Qiwei; Xie, Congkun; Zheng, Qiang; Guo, Jiansheng; Zhang, Yuqi; Wang, Yifan; Li, Xiang; Gu, Zhen; Cai, Xiujun

doi:10.1002/adma.202170390

Cited by 26 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…developed ZnS@BSA nanoclusters composed of BSA coloading zinc and sulfur via an ion diffusion approach for hepatocellular carcinoma (HCC) immunotherapy (Figure 17c). [ 223 ] Albumin was selected for its strong affinity with metal ions, and zinc and sulfur ions were released under acidic TME to produce H 2 S that could specifically inhibit catalase activity in HCC cells. Su et al.…”

Section: Biomacromolecules‐based Hybrid Nanomaterials For Cancer Immu...mentioning

confidence: 99%

Hybrid Nanomaterials for Cancer Immunotherapy

Yang

et al. 2022

Advanced Science

View full text Add to dashboard Cite

Nano-immunotherapy has been recognized as a highly promising strategy for cancer treatment in recent decades, which combines nanotechnology and immunotherapy to combat against tumors. Hybrid nanomaterials consisting of at least two constituents with distinct compositions and properties, usually organic and inorganic, have been engineered with integrated functions and enormous potential in boosting cancer immunotherapy. This review provides a summary of hybrid nanomaterials reported for cancer immunotherapy, including nanoscale metal-organic frameworks, metal-phenolic networks, mesoporous organosilica nanoparticles, metallofullerene nanomaterials, polymer-lipid, and biomacromolecule-based hybrid nanomaterials. The combination of immunotherapy with chemotherapy, chemodynamic therapy, radiotherapy, radiodynamic therapy, photothermal therapy, photodynamic therapy, and sonodynamic therapy based on hybrid nanomaterials is also discussed. Finally, the current challenges and the prospects for designing hybrid nanomaterials and their application in cancer immunotherapy are outlined.

show abstract

Section: Biomacromolecules‐based Hybrid Nanomaterials For Cancer Immu...mentioning

confidence: 99%

Hybrid Nanomaterials for Cancer Immunotherapy

Yang

et al. 2022

Advanced Science

View full text Add to dashboard Cite

show abstract

Section: Cgas‐sting Activation With Nanotechnologymentioning

confidence: 99%

“…Unlike polycation‐based mtDNA release, zinc ion‐loaded NPs activated cGAS‐STING pathway in cancer cells by exerting oxidative stress on mitochondria (Figure 7c). [ 78 ] Zinc ions were formulated with bovine serum albumin and H 2 S to self‐assemble into a nanoparticle (Figure 7c). [ 78 ] Increased zinc ion levels induce mitochondrial dysfunction while H 2 S inhibited the activity of catalase in cancer cells, thus amplifying oxidative stress in mitochondria to promote mtDNA release.…”

Section: Cgas‐sting Activation With Nanotechnologymentioning

confidence: 99%

“…[ 78 ] Zinc ions were formulated with bovine serum albumin and H 2 S to self‐assemble into a nanoparticle (Figure 7c). [ 78 ] Increased zinc ion levels induce mitochondrial dysfunction while H 2 S inhibited the activity of catalase in cancer cells, thus amplifying oxidative stress in mitochondria to promote mtDNA release. [ 78 ] Secretion of type I IFN responses and pro‐inflammatory cytokines by cGAS‐STING activation in cancer cells could stimulate both innate and adaptive immunity to kill the tumor.…”

Section: Cgas‐sting Activation With Nanotechnologymentioning

confidence: 99%

“…[ 78 ] Secretion of type I IFN responses and pro‐inflammatory cytokines by cGAS‐STING activation in cancer cells could stimulate both innate and adaptive immunity to kill the tumor. [ 78 ]…”

Section: Cgas‐sting Activation With Nanotechnologymentioning

confidence: 99%

See 2 more Smart Citations

Harnessing cGAS‐STING Pathway for Cancer Immunotherapy: From Bench to Clinic

Lee

Huntoon

Kang

et al. 2022

Advanced Therapeutics

View full text Add to dashboard Cite

Recent advances in cancer immunotherapy have accomplished clinical successes in certain cancer models over the past decade. However, cancer treatments with adoptive cell transfer or immune checkpoint blockade (ICB) have shown critical limitations against solid tumors, which comprise the majority of human cancers. Thus, novel cancer immunotherapy which harnesses innate immunity process may be required in these tumor types. Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, one of the innate immune sensors, has gained interest in the field of immuno-oncology as activation of this pathway can drive both innate and adaptive immune responses among immunosuppressive tumor microenvironments. Recently, various cGAS-STING-activating strategies have been intensively investigated to achieve durable and widespread therapeutic responses in in vivo models. These meaningful preclinical outcomes have enabled several clinical trials. This review discusses agents targeting various aspects of the cGAS-STING pathway in cancer immunotherapy from benchtop to bedside. Moreover, various approaches to improve the clinical feasibility of cGAS-STING-activating strategies are delineated.

show abstract

Engineering Molybdenum‐Assisted Tellurium Nanosonosensitizers for Enhanced Sonodynamic Tumor Nanotherapy

Dong

Luo

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Materdicine-augmented sonodynamic therapy has emerged as an efficient noninvasive strategy for cancer treatment by generating reactive oxygen species associated with the cavitation effect and sonosensitizers. However, semiconductor-based inorganic nanosonosensitizers have undesirable nondegradability, which can cause unsatisfactory therapeutic efficacy and potential toxicity. With the aim of overcoming this obstacle, in this study, Mo-assisted Te (MT) nanosonosensitizers with high oxidative degradation abilities are engineered for photoacoustic imaging (PA)-guided sonodynamic tumor nanotherapy. Intriguingly, the engineered MT nanosonosensitizers can generate abundant singlet oxygen under ultrasound irradiation to eradicate tumor cells, thereby demonstrating its ability to achieve high tumor growth inhibition rates. In particular, MT nanosonosensitizers exhibit oxidative degradation properties that guarantee desirable biocompatibility and potentiate clinical translation. Therefore, this study validates a paradigm for theoryoriented design of sonodynamic tumor nanotherapy.

show abstract

ZnS@BSA Nanoclusters Potentiate Efficacy of Cancer Immunotherapy (Adv. Mater. 49/2021)

Cited by 26 publications

References 0 publications

Hybrid Nanomaterials for Cancer Immunotherapy

Hybrid Nanomaterials for Cancer Immunotherapy

Harnessing cGAS‐STING Pathway for Cancer Immunotherapy: From Bench to Clinic

Engineering Molybdenum‐Assisted Tellurium Nanosonosensitizers for Enhanced Sonodynamic Tumor Nanotherapy

Contact Info

Product

Resources

About