ZnO Superstructures as an Antifungal for Effective Control of Malassezia furfur, Dermatologically Prevalent Yeast: Prepared by Aloe Vera Assisted Combustion Method

Abstract

In this paper, a robust and simple biogenic route has been developed to synthesize self-assembled ZnO superstructures in short intervals of time using naturally available aloe vera plant gel and zinc nitrate as starting materials. The stabilization of zinc ions with polysaccharides wrapped chains along with the support of proteins, lipids and physterols of aloe vera gel followed by combustion derives the ZnO superstructures. The obtained ZnO superstructures show a hexagonal crystal phase and exhibit a semiconducting behavior with the energy band gap varies from 2.92 to 3.08 eV. The aloe vera gel derived ZnO superstructures exhibit unique and strong orange-red emission centered at 600 nm. The better structural, morphological and photoluminescence results are obtained for ZnO prepared with 16.6% W/V of zinc nitrate with aloe vera content compared to other concentrations of aloe vera. The prepared compounds are tested for antimalassezial activity against Malassezia furfur, dermatologically prevalent yeast, and were found to have minimum inhibitory concentration (MIC) values ranging from 8 to 125 μg/mL. Fluorescence microscopic analysis revealed that yeast cells treated with ZnO superstructures have the chromatin as orange instead of green, showcasing the cell aggregation suggests that ZnO superstructures have an immense potential as an antifungal agent. Hence, the explored method of preparation shows high efficient ZnO superstructures derived from the aloe vera plant gel have potential applications in the medical, biomedical and cosmetic industries.

Biofabrication of Zinc Oxide Nanoparticles With Syzygium aromaticum Flower Buds Extract and Finding Its Novel Application in Controlling the Growth and Mycotoxins of Fusarium graminearum

“…Figure 2B shows the FTIR spectrum of SaZnO NPs acquired in the range of 400–4000 cm -1 . The appearance of peaks in the region of 406 cm -1 is ascribed to the formation of metal-oxygen bond (Kavyashree et al, 2015). The SEM micrographs (Figure 2C) shows the SaZnO NPs formed are of highly agglomerated, to form a well-defined triangular to nearly hexagonal shape in nature, which can be attributed to wurtzite structure of ZnO NPs which is in accordance with recent findings (Velmurugan et al, 2016; Ahmed et al, 2017).…”

Synthesis of Zinc Oxide Nanoparticles by Ecofriendly Routes: Adsorbent for Copper Removal From Wastewater

“…It is one of the most widely studied oxides due to its singular physicochemical properties, that include high chemical stability, and wide light absorption range. Zinc oxide has been announced as active material in a myriad of applications such as antifungal (Kavyashree et al, 2015;Sharma and Ghose, 2015), drug delivery (Yuan et al, 2010;Chen et al, 2013), antibacterial (Jones et al, 2008;Applerot et al, 2009), photocatalysts (Banerjee et al, 2012;Lee et al, 2016), gas sensors (Rai and Yu, 2012;Waclawik et al, 2012) and antioxidant (Kumar et al, 2014). Due to its interesting properties and high applicability, various techniques have been reported for the ZnO synthesis (Kolodziejczak-Radzimska and Jesionowski, 2014).…”

Green synthesis of ZnO hierarchical microstructures by Cordia myxa and their antibacterial activity

“…So far, great deal of effort has been devoted towards exploring the green synthesis routes which is an efficient alternative to chemical and physical methods. The green synthesis of bioactive ZnO nano/micro-structures from various plant resources and their antibacterial, antifungal and photocatalytic activities have been documented by many researchers (Lakshmeesha et al, 2014, Tripathi et al, 2014, Yuvakkumar et al, 2014, Kavyashree et al, 2015, Odoom-Wubah et al, 2016, Udayabhanu et al, 2016).…”