ZnO NPs immobilized by Alizarin as in vitro predictive and imaging biomarkers for protein amyloidosis

Giannousi, Kleoniki; Karageorgou, Maria-Eleni; Oikonomou, Ilias M.; Komninou, Ph.; Dendrinou‐Samara, Catherine

doi:10.1016/j.jinorgbio.2022.111971

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…The surface defects, the band gap width and the physical properties of ZnO nanomaterials can affect their imaging applications. Herein, many researchers have modified the surface of ZnO nanoparticles, widened the band gap and developed new synthesis methods to improve their utilization value, and the ZnO nanoparticles can even be used as carriers to load colorant for assistant imaging [139][140][141][142][143][144][145][146][147][148][149]. Zang et al synthesized ZnO nanoflowers using a biphasic reaction method.…”

Section: Imaging Applicationsmentioning

confidence: 99%

Recent Advances in ZnO Nanomaterial-Mediated Biological Applications and Action Mechanisms

Xie

Zhang

et al. 2023

Nanomaterials

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In recent years, with the deepening research, metal zinc oxide (ZnO) nanomaterials have become a popular research object in the biological field, particularly in biomedicine and food safety, which is attributed to their unique physicochemical properties such as high surface area and volume ratio, luminescence effect, surface characteristics and biological activities. Herein, this review provides a detailed overview of the ZnO nanomaterial-mediated biological applications that involve anti-bacterial, anti-tumor, anti-inflammation, skin care, biological imaging and food packaging applications. Importantly, the corresponding action mechanisms of ZnO nanomaterials are pointed. Additionally, the structure and structure-dependent physicochemical properties, the common synthesis methods and the biosafety of ZnO nanoparticles are revealed in brief. Finally, the significance and future challenges of ZnO nanomaterial applications are concluded.

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Section: Imaging Applicationsmentioning

confidence: 99%

Recent Advances in ZnO Nanomaterial-Mediated Biological Applications and Action Mechanisms

Xie

Zhang

et al. 2023

Nanomaterials

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“…Various nanostructures materials, including nanorods, nanotubes, and nanoplates, have been used as efficient catalyst carriers. In recent years, artistic flower-like nanomaterials [nanoflowers (NFs)] have gained the attention due to their very high specific surface area. , This unique feature is beneficial to the surface reactions efficiency and loading capacity, which makes these NFs become perfect candidates for enzyme immobilization. , An innovative technique for preparation of protein-inorganic hybrid NFs (hNFs) was accidently discovered by Ge . This technique simply involves the addition of a metal ion solution into phosphate-buffered saline (PBS) containing proteins (organic component) and incubation for a period of time.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, artistic flower-like nanomaterials [nanoflowers (NFs)] have gained the attention due to their very high specific surface area. 18,19 This unique feature is beneficial to the surface reactions efficiency and loading capacity, which makes these NFs become perfect candidates for enzyme immobilization. 20,21 An innovative technique for preparation of protein-inorganic hybrid NFs (hNFs) was accidently discovered by Ge.…”

Section: ■ Introductionmentioning

confidence: 99%

Immobilization of Nuclease P1 Based on Hybrid Nanoflowers with Tremendously Enhanced Catalytic Activity and Stability

Chen

Appiah

Zou

et al. 2023

Ind. Eng. Chem. Res.

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Organic−inorganic hybrid nanoflowers (hNFs), as a novel enzyme immobilization mode, have gained extensive attention in recent years owing to their unique high specific surface area and distinctive microstructure. For the first time, a nuclease P1(NP1)-inorganic hNF (NP1-hNF) was prepared by the self-assembly co-precipitation method using CaCl 2 as the inorganic component and BSA as an inert protein. The hNF microstructure of the prepared NP1-hNFs was confirmed by scanning electron microscopy. With adding inert protein BSA, the NP1-hNFs displayed dramatically enhanced catalytic activity and improved thermal stability compared with the free enzyme. The enzyme activity yield in the immobilization process reached 266%. Comparing with the free NP1, the optimum reaction temperature of the NP1-hNFs increased 10 °C. The NP1-hNFs were further entrapped in calcium alginate microbeads to improve their reusability. The NP1-hNF microbeads retained 65% of residual activity after five recycle uses. Additionally, the microbeads retained up to 96% residual activity after 50 days of storage. This provides a promising route for enzyme immobilization in industrial application.

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The conceptual design of pH responsive ZnO-adamantane nanosystems for insulin amyloidosis

Giannousi,

Kasapidou,

Oikonomou

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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ZnO NPs immobilized by Alizarin as in vitro predictive and imaging biomarkers for protein amyloidosis

Cited by 4 publications

References 38 publications

Recent Advances in ZnO Nanomaterial-Mediated Biological Applications and Action Mechanisms

Recent Advances in ZnO Nanomaterial-Mediated Biological Applications and Action Mechanisms

Immobilization of Nuclease P1 Based on Hybrid Nanoflowers with Tremendously Enhanced Catalytic Activity and Stability

The conceptual design of pH responsive ZnO-adamantane nanosystems for insulin amyloidosis

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