ZnO Applications and Challenges

Oprea, Ovidiu; Andronescu, Ecaterina; Ficai, Denisa; Ficai, Anton; Oktar, Faik N.; Yetmez, Mehmet

doi:10.2174/13852728113176660143

Cited by 69 publications

(51 citation statements)

References 141 publications

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“…Its band gap has a significant effect on the electrical conductivity and optical absorption, making it transparent in the visible light region. Moreover, ZnO is listed as safe by the US Food and Drug Administration (21CFR182.8991) [21] and classified as a lowcost material, easy to process, abundant in nature, biosafe, biocompatible, non-toxic and, more important in this case, it presents antimicrobial activity against both bacteria [22] and fungi [23].…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of ZnO thin films prepared by glancing angle deposition

et al. 2019

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Highlights• Zinc Oxide thin films were deposited by reactive magnetron sputtering;• Inclined columns changed the thin films' surface porosity;• Sputtering incidence angle affects microstructure and antifungal properties;• Mesoporous thin films improved the antifungal properties against Candida albicans; ABSTRACTThin films of zinc oxide (ZnO) were produced by reactive DC magnetron sputtering with sputtering angles of α = 0º, 40º, 60º and 80º (glancing angle deposition configuration), aiming to be tested against the opportunist pathogenic fungus Candida albicans. The results showed the formation of stoichiometric ZnO thin films, with inclined columns for incidence angles equal to or more than 40º. All thin films presented high transparency in the visible range above the bandgap region (near 380 nm). The deposition conditions gave rise to a three-fold increase of the surface porosity with the increment of the incidence angle. Noteworthy, is the formation of different types of pores distributions, from micro-, through meso-, to macropores. Regarding the biological effect, the thin films produced with inclined columns presented a significant antifungal activity, with the inhibition of viable cell growth by 68 %. Moreover, the formation of mesoporous films enhanced the antifungal properties of ZnO thin films against Candida albicans. The overall behaviour indicates that these thin films are promising candidates to be applied in antimicrobial surfaces, as well as to be used in further studies to determine the molecular mechanisms involved in the antimicrobial action of ZnO.3

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Section: Introductionmentioning

confidence: 99%

Antifungal activity of ZnO thin films prepared by glancing angle deposition

et al. 2019

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“…The role of the main product of zinc biodegradation (Zn 2+ ) in numerous fundamental cellular processes is considered in [136]. The formation of ZnO is beneficial because it induces a slightly antimicrobial activity, which can avoid biofilm formation [59,[137][138][139][140].…”

Section: Zn Stentsmentioning

confidence: 99%

Recent Advances in Manufacturing Innovative Stents

et al. 2020

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Cardiovascular diseases are the most distributed cause of death worldwide. Stenting of arteries as a percutaneous transluminal angioplasty procedure became a promising minimally invasive therapy based on re-opening narrowed arteries by stent insertion. In order to improve and optimize this method, many research groups are focusing on designing new or improving existent stents. Since the beginning of the stent development in 1986, starting with bare-metal stents (BMS), these devices have been continuously enhanced by applying new materials, developing stent coatings based on inorganic and organic compounds including drugs, nanoparticles or biological components such as genes and cells, as well as adapting stent designs with different fabrication technologies. Drug eluting stents (DES) have been developed to overcome the main shortcomings of BMS or coated stents. Coatings are mainly applied to control biocompatibility, degradation rate, protein adsorption, and allow adequate endothelialization in order to ensure better clinical outcome of BMS, reducing restenosis and thrombosis. As coating materials (i) organic polymers: polyurethanes, poly(ε-caprolactone), styrene-b-isobutylene-b-styrene, polyhydroxybutyrates, poly(lactide-co-glycolide), and phosphoryl choline; (ii) biological components: vascular endothelial growth factor (VEGF) and anti-CD34 antibody and (iii) inorganic coatings: noble metals, wide class of oxides, nitrides, silicide and carbide, hydroxyapatite, diamond-like carbon, and others are used. DES were developed to reduce the tissue hyperplasia and in-stent restenosis utilizing antiproliferative substances like paclitaxel, limus (siro-, zotaro-, evero-, bio-, amphi-, tacro-limus), ABT-578, tyrphostin AGL-2043, genes, etc. The innovative solutions aim at overcoming the main limitations of the stent technology, such as in-stent restenosis and stent thrombosis, while maintaining the prime requirements on biocompatibility, biodegradability, and mechanical behavior. This paper provides an overview of the existing stent types, their functionality, materials, and manufacturing conditions demonstrating the still huge potential for the development of promising stent solutions.

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“…The mechanism of action of nanoparticles is very important and differ depending on the nature and characteristics of nanoparticles [11,13,31,[98][99][100][101][102][103][104]. In the case of silver nanoparticles, the antimicrobial and anti-fungal activity is mainly assured by the produced Reactive Oxygen Species (ROS) which are altering the normal, intracellular functions of these micro-organisms while, most of the metal oxides (ZnO, MgO and CaO) are inducing a cellular wall destruction and consequently these microorganisms are losing their integrity.…”

Section: Green Synthesis Of Silver Nanomaterialsmentioning

confidence: 99%

Toward Synthesis-derived Applications of Silver Nanoparticles

Spoială¹,

Ficai²,

Craciun³

et al. 2020

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This paper aims to review the challenges, toxicity, and routes of synthesis and usage of silver nanoparticles in different medical applications but also highlighting their sustainability from both medical and environmental issues. Regarding their toxicity, it is known that silver nanoparticles can destroy over 650 microorganisms comparing with antibiotics. Supplementary, will be presented in a comparative manner some conventional synthesis routes (physical and chemical methods) and green synthesis routes using plant extracts. The approach using plant extracts have various advantages comparing with physical, chemical and microbial synthesis methods because there is no need to use chemicals, wasteful purifications and high energy requirements. The main focus in “green nanotechnology” was to use either biological micro-organisms or plant extracts which are an alternative to the classical chemical and physical methods. An important issue that is discussed in the paper is the potential toxicity of silver nanoparticles that may have on human health or on the environment, which powerfully indicates that, the usage and removal of silver nanoparticles must be carefully examined. Also, it needs to focus our attention on the dismissal of silver nanoparticles into the environment and especially in water systems, fact which suggests that this issue must be fully understood and apply accordingly the law.

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ZnO Applications and Challenges

Cited by 69 publications

References 141 publications

Antifungal activity of ZnO thin films prepared by glancing angle deposition

Antifungal activity of ZnO thin films prepared by glancing angle deposition

Recent Advances in Manufacturing Innovative Stents

Toward Synthesis-derived Applications of Silver Nanoparticles

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