ZnO and TiO2 nanoparticles as novel antimicrobial agents for oral hygiene: a review

Khan, Shams Tabrez; Al-Khedhairy, Abdulaziz A.; Musarrat, Javed

doi:10.1007/s11051-015-3074-6

Cited by 80 publications

(49 citation statements)

References 165 publications

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“…Photoactivated TiO 2 exhibited good antimicrobial activity in laboratory assays and can kill various microorganisms including bacteria in the laboratory bioassays due to production of ROS (Kiwi & Nadtochenko 2005;Foster et al 2011;Kubacka et al 2014;Khan et al 2015). In marine environments, the interaction between TiO 2 nanoparticles and the formation of microbial biofilms on submerged surfaces is poorly understood.…”

Section: Settlement Assaymentioning

confidence: 99%

The effect of carbon nanotubes and titanium dioxide incorporated in PDMS on biofilm community composition and subsequent mussel plantigrade settlement

Yang

Guo

et al. 2016

Biofouling

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This study investigated the effect of carbon nanotubes (CNTs) and titanium dioxide (TiO2) incorporated in PDMS on biofilm formation and plantigrade settlement of Mytilus coruscus. TiO2 increased bacterial density, and CNTs also increased bacterial density but reduced diatom density in biofilms after 28 days. Further analysis was conducted between bacterial communities on glass, PDMS, CNTs (0.5 wt%) and TiO2 (7.5 wt%). ANOSIM analysis revealed significant differences (R > 0.9) between seven, 14, 21 and 28 day-old bacterial communities. MiSeq sequencing showed that CNTs and TiO2 impacted the composition of 28 day-old bacterial communities by increasing the abundance of Proteobacteria and decreasing the abundance of Bacteroidetes. The maximum decreased settlement rate in 28 day-old biofilms on CNTs and TiO2 was > 50% in comparison to those on glass and PDMS. Thus, CNTs and TiO2 incorporated in PDMS altered the biomass and community composition of biofilms, and subsequently decreased mussel settlement.

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Section: Settlement Assaymentioning

confidence: 99%

The effect of carbon nanotubes and titanium dioxide incorporated in PDMS on biofilm community composition and subsequent mussel plantigrade settlement

Yang

Guo

et al. 2016

Biofouling

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“…So-called nanoantibiotics exploiting this phenomenon are currently developed (Khan, Al-Khedhairy, & Musarrat, 2015). So-called nanoantibiotics exploiting this phenomenon are currently developed (Khan, Al-Khedhairy, & Musarrat, 2015).…”

Section: Discussion and Con Clus I On Smentioning

confidence: 99%

“…It must be mentioned that there are also observations that are not in line with this hypothesis: First, metal oxide nanoparticles, especially of TiO 2 , possess antimicrobial activity. So-called nanoantibiotics exploiting this phenomenon are currently developed (Khan, Al-Khedhairy, & Musarrat, 2015). Second, in dental implantology, aseptic loosening has been associated rather with zirconia implants than with titanium implants (Cionca, Müller, & Mombelli, 2015).…”

Section: Discussion and Con Clus I On Smentioning

confidence: 99%

What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review

Mombelli

Hashim

2018

Clinical Oral Implants Res

153

137

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Objectives To compile the current evidence regarding the association between the release of titanium particles and biologic complications of dental implants. Material and methods This is a critical review. We searched the literature using the terms “corrosion,” “allergy,” “hypersensitivity,” or “particles” together with “titanium,” “Ti,” “TiO2.” The bibliographies of identified publications and previously published review articles were scanned to find additional related articles. We included clinical studies, in vivo and in vitro experiments. Results Titanium particles and degradation products of titanium have been detected in oral and nonoral tissues. Particles are released from surfaces of dental implants because of material degradation in a process called tribocorrosion. It involves mechanical wear and environmental factors, notably contact to chemical agents and interaction with substances produced by adherent biofilm and inflammatory cells. In vitro, titanium particles can interfere with cell function and promote inflammation. A temporal association between exposure to titanium and occurrence of tissue reactions suggested hypersensitivity in a limited number of cases. However, there is poor specificity as the observed reactions could be initiated by other factors associated with the placement of implants. Titanium particles are commonly detected in healthy and diseased peri‐implant mucosa alike, at low levels even in gingiva of individuals without titanium implants. Rather than being the trigger of disease, higher concentrations of titanium in peri‐implantitis lesions could be the consequence of the presence of biofilms and inflammation. Conclusion There is an association between biocorrosion, presence of titanium particles, and biological implant complications, but there is insufficient evidence to prove a unidirectional causal relationship.

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“…Antimicrobial efficiency of TiO 2 NP was recently demonstrated [42], although the impact of such nanoparticles on human or animal microbiota are far from being understood. However, TiO 2 NP, along with zinc oxide, were proposed to be highly efficient antimicrobial agents for oral hygiene; these nanoparticles inhibit biofilm formation and are efficient against oral pathogens causing periodontal diseases, thus, against oral microbiota species [43]. …”

Section: Antimicrobial Nanosystems For Gastrointestinal Drug Delivmentioning

confidence: 99%

Nanosized Drug Delivery Systems in Gastrointestinal Targeting: Interactions with Microbiota

Karavolos

Holban

2016

Pharmaceuticals

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The new age of nanotechnology has signaled a stream of entrepreneurial possibilities in various areas, form industry to medicine. Drug delivery has benefited the most by introducing nanostructured systems in the transport and controlled release of therapeutic molecules at targeted sites associated with a particular disease. As many nanosized particles reach the gastrointestinal tract by various means, their interactions with the molecular components of this highly active niche are intensively investigated. The well-characterized antimicrobial activities of numerous nanoparticles are currently being considered as a reliable and efficient alternative to the eminent world crisis in antimicrobial drug discovery. The interactions of nanosystems present in the gastrointestinal route with host microbiota is unavoidable; hence, a major research initiative is needed to explore the mechanisms and effects of these nanomaterials on microbiota and the impact that microbiota may have in the outcome of therapies entailing drug delivery nanosystems through the gastrointestinal route. These coordinated studies will provide novel techniques to replace or act synergistically with current technologies and help develop new treatments for major diseases via the discovery of unique antimicrobial molecules.

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ZnO and TiO2 nanoparticles as novel antimicrobial agents for oral hygiene: a review

Cited by 80 publications

References 165 publications

The effect of carbon nanotubes and titanium dioxide incorporated in PDMS on biofilm community composition and subsequent mussel plantigrade settlement

The effect of carbon nanotubes and titanium dioxide incorporated in PDMS on biofilm community composition and subsequent mussel plantigrade settlement

What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review

Nanosized Drug Delivery Systems in Gastrointestinal Targeting: Interactions with Microbiota

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