ZnO and quercetin encapsulated nanoparticles for sun protection obtained by miniemulsion polymerization using alternative co-stabilizers

Abstract

The present work evaluated the encapsulation of ZnO and quercetin in PBMA-PMMA-PS using the miniemulsion polymerization technique, aiming to develop nanoparticles with sun protection factor (SPF) and antioxidant activity (AA) for application in photoprotective lotions. In both formulations, octocrylene and green coffee oil were tested as co-stabilizing agents of the miniemulsion, being also encapsulated in the NPs, contributing to the SPF and AA of the obtained latexes. Spherical nanoparticles of homogeneous size, from 169 to 346 nm, and regular surfaces were obtained, remaining stable for at least 30 days. The encapsulation efficiency on the formulations tested was from 59 to 87% for ZnO, 47 to 51% for quercetin, 80 to 92% for octocrylene and 90 to 92% for green coffee oil. The quercetin and green coffee oil presented high antioxidant activity when encapsulated in polymeric NPs. The values of in vitro SPF was very good for formulations containing NPs-ZnO, with the best result for the simultaneous nanoencapsulation of ZnO and octocrylene (SPF 29±5). The application of the NPs of quercetin and green coffee oil may promote an increment on SPF in vivo, reducing the damage caused to the skin by UV radiation, beyond the ability to scavenge the free radicals generated by ZnO.

Encapsulation of ZnO and Ho:ZnO Nanoparticles in the Core of Wrinkled Mesoporous Silica

“…Manuja et al explored the use of alginate and gum acacia as biocompatible matrices, which resulted in improved biocompatibility and reduced toxicity of the encapsulated ZnO nanoparticles . Fogaça et al focused on mini-emulsion polymerization to encapsulate ZnO and quercetin in PBMA-PMMA-PS, which created nanoparticles with both sun protection factor and antioxidant activity for use in photoprotective lotions . Previous studies have demonstrated the importance of encapsulating ZnO NPs for various applications using different matrix materials. , The wrinkled mesoporous shell provides a layer of protection to safeguard and preserve the encapsulated nanoparticle.…”

An overview of the science and art of encapsulated pigments: Preparation, performance and application

“…This droplet’s nucleation limits compound structural defects and even promote nanoparticle dispersion 77 . As part of the in situ encapsulation technique, this reaction process involves polymer synthesis and encapsulation 78 76,79 .…”

“…77 As part of the in situ encapsulation technique, this reaction process involves polymer synthesis and encapsulation. 78 Mini-emulsion encapsulation has been described as a two-way process, where finely dispersed stable droplets are formed in the second continuous phase. 76,79 However, other research has indicated that direct dispersions of carbon black or organic pigments in a monomer (eg, styrene) are highly possible.…”

Drug Delivery Strategies for Avobenzone: A Case Study of Photostabilization

“…The entrapment efficiency of photostabilizers such as octocrylene loaded with UV filters such as avobenzone needs more exploration and upgradation in combination with antioxidants and quenchers. There is also a scope to investigate the impact of strategies on the delivery of UV filters by varying several processing factors, formulation factors and materials used for the same [ 29 , 99 , 100 ].…”