ZNF804A rs1344706 gene polymorphism and clinical heterogeneity of schizophrenia

Лежейко, Т. В.; Gabaeva, M. V.; Krikova, Ekaterina V.; Голимбет, В. Е.

doi:10.18413/2658-6533-2020-6-1-0-5

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Эти различия могут быть связаны с неоднородностью исследуемых выборок. Кроме того, шизофрения представляет собой достаточно гетерогенную группу заболеваний, в основе которых могут лежать различные нейробиологические механизмы [16]. Существенная гетерогенность шизофрении препятствует нашим усилиям по обеспечению адекватного лечения.…”

Section: Introductionunclassified

“…Иллюзия Понцо была выбрана для настоящего исследовании потому, что, во-первых, механизмы ее формирования предположительно связаны с областями мозга, содержащими бинокулярные нейроны (т.е. начиная с V1 и далее) [16,26]. Считается, что эти области мозга меняют свои свойства при шизофрении [27].…”

Section: Introductionunclassified

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Detection of Cognitive Subtypes of Schizophrenia (with Assessment of Perceptual Disorders). A Pilot Study

et al. 2023

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Background: the heterogeneity of schizophrenia impedes our efforts to provide adequate treatment. One step toward optimizing treatment is to deepen our understanding of cognitive variety in this disorder. Perhaps due to this heterogeneity, although visual impairment is a frequent symptom of schizophrenia, many studies show inconsistent data. The aim of our study was to identify homogeneous groups of patients with schizophrenia based on susceptibility to the Ponzo illusion, cognitive impairment degree (BACS T-score) and severity of mental state during therapy (Total PANSS score) and to examine the relationship between clinical parameters and the value of the illusion. Patients and methods: a prospective six-week observational study included 30 patients with the paranoid form of schizophrenia in the second week of stable antipsychotic monotherapy, 11 of whom dropped out due to exclusion criteria. At the second and eighth weeks of treatment, patients were assessed for susceptibility to the Ponzo illusion, cognitive impairment using a battery of BACS tests, and severity of mental status during a semi-structured interview using the PANSS scale. Results: the cluster analysis identified 2 clusters of patients who differed in their susceptibility to the Ponzo illusion. Patients in the first cluster (n = 9) with a significantly higher score on negative PANSS symptoms and marked cognitive impairment in the second and eighth weeks of therapy were prone to overestimate the Ponzo illusion, while patients in the second cluster (n = 10) were less susceptible to the Ponzo illusion. Conclusions: this study allowed us to identify two clusters of patients differing in the severity of cognitive and visual impairments, the relationship of susceptibility to Ponzo illusion with such clinical indicators as negative and cognitive symptoms was demonstrated, which confirms the informative value of using the visual illusion methodology as a marker of mental state.

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Section: Introductionunclassified

Detection of Cognitive Subtypes of Schizophrenia (with Assessment of Perceptual Disorders). A Pilot Study

et al. 2023

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Impact on the Risk and Severity of Childhood Onset Schizophrenia of Schizophrenia Risk Genetic Variants at the DRD2 and ZNF804A Loci

Алфимова

Никитина

Лежейко

et al. 2021

Child Psychiatry Hum Dev

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ASSOCIATION OF THE <i>ZNF804A rs1344706</i> GENE POLYMORPHISM WITH THE INDUCED EEG RHYTHMS IN VISUAL PERCEPTION OF THE VERBAL STIMULI IN HEALTHY SUBJECTS AND IN SCHIZOPHRENIA

Garakh,

Golimbet,

Larionova

et al. 2023

I.P. Pavlov Journal of Higher Nervous Activity

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We studied the relationship between the ZNF804A rs1344706 gene polymorphism and the parameters of event-related synchronization/desynchronization of EEG rhythms in visual perception of semantic and meaningless verbal information in patients with schizophrenia and schizophrenia spectrum disorders (n = 93) and mentally healthy subjects (n = 93). When reading verbal information regardless of psychiatric status, the theta rhythm synchronization was less pronounced in subjects with the AA genotype than in carriers of allele C. In healthy subjects, the carriers of the AA genotype, in comparison with carriers of allele C, the synchronization of theta rhythm in the posterior cortical areas of the left hemisphere was reduced, and there were no differences in the synchronization of gamma and desynchronization of mu rhythms when perceiving semantic and nonsensical verbal information. In patients with genotype AA, compared with carriers of allele C, the desynchronization of mu rhythm was smaller, which correlated with the severity of poverty of speech on the PANSS scale. The study results indicate a modulating effect of the rs1344706 polymorphism of the ZNF804A gene on the neurophysiological characteristics of the reading process and its contribution to the variability of clinically expressed language disorders.

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ZNF804A rs1344706 gene polymorphism and clinical heterogeneity of schizophrenia

Cited by 3 publications

References 8 publications

Detection of Cognitive Subtypes of Schizophrenia (with Assessment of Perceptual Disorders). A Pilot Study

Detection of Cognitive Subtypes of Schizophrenia (with Assessment of Perceptual Disorders). A Pilot Study

Impact on the Risk and Severity of Childhood Onset Schizophrenia of Schizophrenia Risk Genetic Variants at the DRD2 and ZNF804A Loci

ASSOCIATION OF THE <i>ZNF804A rs1344706</i> GENE POLYMORPHISM WITH THE INDUCED EEG RHYTHMS IN VISUAL PERCEPTION OF THE VERBAL STIMULI IN HEALTHY SUBJECTS AND IN SCHIZOPHRENIA

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