ZNF703 acts as an oncogene that promotes progression in gastric cancer

Yang, Gong‐Li; Ma, Feng; Zhong, Meifeng; Lin, Fang; Peng, Yuling; Xin, Xiaoming; Zhong, Jietao; Yuan, Fangfang; Gu, Huijie; Zhu, Wei; Zhang, Yali

doi:10.3892/or.2014.2997

Cited by 34 publications

(36 citation statements)

References 24 publications

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“…ZNF703 is a zinc finger transcription factor belongs to NET/NLZ family and contributes to the development and progression of various cancer, including NSCLC, breast cancer, gastric cancer (GC), and colorectal cancer (CRC). [40][41][42] Moreover, ZNF703 is involved in the activation of the Akt/mammalian target of rapamycin (mTOR) signaling pathway in breast cancer cell lines. 43 Therefore, Shi et al 11 detected the potential roles of ZNF703 in breast cancer cell lines and discovered that ZNF703 is augmented in breast cancer tissues and cell lines.…”

Section: Breast Cancermentioning

confidence: 99%

SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers

Chen

et al. 2017

Tumour Biol.

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Long non-coding RNAs are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that long non-coding RNAs are involved in various cellular processes, including proliferation, differentiation, cell death, and metastasis. Among numerous long non-coding RNAs, we focus on Sprouty4-Intron 1 (SPRY4-IT1), a well-known long non-coding RNA that is overexpressed in various kinds of tumor tissues and cell lines. Accumulating evidences show that SPRY4-IT1 was dysregulated in various cancers, including melanoma, breast cancer, esophageal squamous cell carcinoma, non-small cell lung cancer, gastric cancer, colon cancer, and hepatocellular carcinoma, and amplification of SPRY4-IT1 was associated with different clinicopathological features of cancer patients. Importantly, SPRY4-IT1 exerts important roles in tumor progression and metastasis. However, detailed molecular mechanisms of SPRY4-IT1 in cancer progression and metastasis were poorly understood. In this review, we have focused on the characteristics of SPRY4-IT1 and illustrated the biological function and mechanism of SPRY4-IT1 in cancer development.

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Section: Breast Cancermentioning

confidence: 99%

SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers

Chen

et al. 2017

Tumour Biol.

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“…There exist a number of publications describing the correlation between the expression of ZNF280B and the growth of various types of cancer (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). For example, Gunn et al (22) reported that ZNF280B acts as a tumor suppressor in chronic lymphocytic leukemia.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies has reported that ZNF proteins serve critical roles in human cancers (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). For example, ZNF703 acts as an oncogene in invasive gastric carcinoma, and its expression levels are correlated with gastric carcinoma progression (16). The downregulation of ZNF306 expression reduces tumorigenicity in colorectal cancer (17).…”

Section: Introductionmentioning

confidence: 99%

ZNF280B promotes the growth of gastric cancer inï¿½vitro and inï¿½vivo

et al. 2018

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Abstract. Zinc finger protein 280B (ZNF280B) mediates pro-survival and pro-growth functions in prostate cancer. However, in gastric cancer, its clinical significance remains poorly characterized. In the present study, the expression levels of ZNF280B in 60 patients with gastric cancer were examined using immunohistochemistry. The association between ZNF280B expression and clinicopathological features was assessed. Positive ZNF280B staining was demonstrated for 38 (63.3%) samples out of 60 gastric cancer cases in immunohistochemical analysis. ZNF280B expression was significantly associated with tumor size (P= 0.017) and TNM stage (P= 0.001). Furthermore, the proliferation index in the positive ZNF280B expression group was significantly higher (38.8±6.2) compared with that of the negative ZNF280B expression group (16.9±8.9; P<0.01). These results suggest that ZNF280B expression may be associated with the proliferation of gastric cancer cells. The role of ZNF280B in the growth of gastric cancer cells (MGC-803) was also investigated in vitro and in vivo by enhancing the expression of ZNF280B. A colony formation assay indicated that the number of colonies in the MGC-803 cells with enhanced ZNF280B (146±5.8) was significantly higher than that of the MGC-803 control group (97±5.1) and the negative control group (101±6.5; P<0.05). An MTT assay demonstrated that ZNF280B significantly promoted the proliferation of MGC-803 cells at days 3 and 4 (P<0.05). It was observed that the overexpression of ZNF280B may promote the growth of gastric cancer in vivo in xenograft studies. These findings indicate that ZNF280B may be a novel therapeutic target for gastric cancer.

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“…ZNF703, a member of zinc finger transcription factors, is located on chromosomes 8 (8p11.23), contributes to aspects of growth and patterning across evolutionarily diverse species [22] . ZNF703 has been identified as a novel oncogene in human breast cancer [23] , colorectal cancer [24] , gastric cancer [22] , etc.…”

Section: Regulate Znf703 Genementioning

confidence: 99%

“…ZNF703 has been identified as a novel oncogene in human breast cancer [23] , colorectal cancer [24] , gastric cancer [22] , etc. ZNF703 has been demonstrated promotes ER(−) breast carcinoma cell proliferation and suppresses apoptosis in vivo, and recently studies showed that ZNF703 could be regulated by SPRY4-IT1 as a downstream target gene of SPRY4-IT1 [14] .…”

Section: Regulate Znf703 Genementioning

confidence: 99%

Long non-coding RNA SPRY4-IT1: a new player in different diseases

2015

RNA Dis

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Long non-coding RNAs (lncRNAs) refer to a class of RNA molecules with poor protein coding potential and are usually larger than 200 nucleotides. SPRY4-IT1, a member of lncRNA, is derived from an intronic region within the SPRY4 gene. And accumulating evidence demonstrates that aberrant expression of SPRY4-IT1 is involved in the development of various diseases such as melanoma, esophageal squamous cell carcinoma (ESCC), renal cancer, gastric cancer, breast cancer, bladder cancer, Non-small-cell lung cancer (NSCLC), and preeclampsia. SPRY4-IT1 is significantly related to not only progression and prognosis of diseases but also cell proliferation, migration, invasion. SPRY4-IT1 contributes to various diseases via different molecular mechanism such as regulating the expression of proteins related to cell growth and migration, involving in epithelial-mesenchymal transition (EMT), affecting lipid metabolism, and regulating downstream gene expression. Moreover, SPRY4-IT1 can also be regulated by some epigenetic factors including Zeste homolog 2 (EZH2). Therefore, SPRY4-IT1 may be a novel prognostic biomarker and a potential therapeutic candidate for different diseases including various solid cancers and preeclampsia.

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ZNF703 acts as an oncogene that promotes progression in gastric cancer

Cited by 34 publications

References 24 publications

SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers

SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers

ZNF280B promotes the growth of gastric cancer inï¿½vitro and inï¿½vivo

Long non-coding RNA SPRY4-IT1: a new player in different diseases

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