Zn<sup>2+</sup>‐Responsive Bimodal Magnetic Resonance Imaging and Fluorescence Imaging Agents and Their Interaction with Human Serum Albumin

Xu, Yingqi; Luo, Jian; Chen, Zhong‐Ning

doi:10.1002/ejic.201402197

Cited by 15 publications

(8 citation statements)

References 43 publications

(59 reference statements)

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“…Magnetic resonance imaging (MRI) has become a powerful tool in the clinical diagnosis of disease and imaging in vivo owing to the noninvasive character and high spatial resolution in soft issue. , Because of the highly paramagnetic nature, Gd III ions are often chosen as the metal connectors to construct MOF contrast agents for MRI. − Herein we attempt to investigate the MRI property of the captured Gd III centers within cavities of ZIF. Figure S17 shows representative transmission electron microscopy (TEM) images of the as-synthesized 1 ⊂ sod -ZIF nanoparticles prepared by the mechanochemical method, whose sizes are distributed roughly from 70 to 200 nm.…”

Section: Resultsmentioning

confidence: 99%

Versatile and Efficient Mechanochemical Synthesis of Crystalline Guest⊂Zeolitic Imidazolate Framework Complexes by in Situ Host–Guest Nanoconfinement

Gao

Shi

et al. 2018

Crystal Growth & Design

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In this work, the one-pot mechanochemical synthesis was demonstrated to be a versatile and efficient method to prepare hybrid guest⊂ZIF (ZIF = zeolitic imidazolate framework) materials with high crystallinity, and up to 18 functional guest molecules with different sizes, shapes, and properties were encapsulated into interior cavities of ZIFs with high guest loading. These guest molecules can be accommodated within the different cavities of sod- or rho-ZIFs, depending on the sizes of guest. Because of the relatively small opening of ZIFs, the guest molecules can be immobilized by physical imprisonment and cannot be released without destroying the host matrix. More importantly, the obtained guest⊂ZIF materials were endowed with various interesting properties originated from the encaged guest molecules, which significantly extends the functionality of metal–organic frameworks. For instance, poly(ethylene glycol)-decorated nanoparticles of a sod-ZIF (i.e., ZIF-8) encapsulating gadolinium complex exhibit interesting property of magnetic resonance imaging, and a rho-ZIF (i.e., MAF-6) with metalloporphyrin embedded can be used as an effective heterogeneous catalyst for epoxidation of styrene.

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Section: Resultsmentioning

confidence: 99%

Versatile and Efficient Mechanochemical Synthesis of Crystalline Guest⊂Zeolitic Imidazolate Framework Complexes by in Situ Host–Guest Nanoconfinement

Gao

Shi

et al. 2018

Crystal Growth & Design

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“…HSA, encapsulating drugs or genes ether in its monomeric native formula or nanoparticle formula, has significantly improved the therapeutic efficacy of agents in a variety of human diseases including neutropenia, haemostasis, substance abuse, and oncology [7,12]. So far, a number of HSA-based conjugates have been approved for human use and some are under clinical trials for future applications [108,[153][154][155].…”

Section: Discussionmentioning

confidence: 99%

Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin

Liu

Mu²,

Xing³

2015

CPD

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Human serum albumin (HSA), a major transport protein component in blood plasma, has been reported recently to play many important roles in pharmacotherapeutics development. Owing to its promising intrinsic binding capability of drug molecules, HSA offers favorable characteristics and can be directly used as its monomeric formula or can be fabricated into protein based nanoparticle platforms to realize the effective delivery of therapeutic molecules into targeted diseases areas. In addition, HSA can also serve as a protein stabilizer or environment-responsive moieties to hybridize with the functional materials including polymers or inorganic nanoparticles through the covalent reactions or electrostatic interactions, and can thus greatly alter the relevant biological distribution and pharmacokinetic behavior to improve their therapeutic efficacy. By right, extensive studies have been conducted to develop HSA-conjugated pharmacotherapeutic agents toward effective in vitro and in vivo diseases diagnosis and treatment. The current review gives an in-detail account of the latest progresses of HSA-based carriers as functional protein materials, mainly with respect to its conjugation types, formulation aspects, and importantly their promising applications towards enhanced drug delivery and medical diagnosis.

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“…To circumvent the problem and prevent the formation of the dimeric species, GdP24 (Figure 6) was successfully designed. In this case, the sulfoquinoline is in the para position of the benzene, far away from the amide, leading to the formation of only (GdP24) 2 Zn with an affinity for Zn 2+ in the pM range [61].…”

Section: Small Molecular Probes For Zn 2+ Detectionmentioning

confidence: 99%

From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges

2020

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Zinc and copper are essential cations involved in numerous biological processes, and variations in their concentrations can cause diseases such as neurodegenerative diseases, diabetes and cancers. Hence, detection and quantification of these cations are of utmost importance for the early diagnosis of disease. Magnetic resonance imaging (MRI) responsive contrast agents (mainly Lanthanide(+III) complexes), relying on a change in the state of the MRI active part upon interaction with the cation of interest, e.g., switch ON/OFF or vice versa, have been successfully utilized to detect Zn2+ and are now being developed to detect Cu2+. These paramagnetic probes mainly exploit the relaxation-based properties (T1-based contrast agents), but also the paramagnetic induced hyperfine shift properties (paraCEST and parashift probes) of the contrast agents. The challenges encountered going from Zn2+ to Cu2+ detection will be stressed and discussed herein, mainly involving the selectivity of the probes for the cation to detect and their responsivity at physiologically relevant concentrations. Depending on the response mechanism, the use of fast-field cycling MRI seems promising to increase the detection field while keeping a good response. In vivo applications of cation responsive MRI probes are only in their infancy and the recent developments will be described, along with the associated quantification problems. In the case of relaxation agents, the presence of another method of local quantification, e.g., synchrotron X-Ray fluorescence, single-photon emission computed tomography (SPECT) or positron emission tomography (PET) techniques, or 19F MRI is required, each of which has its own advantages and disadvantages.

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Zn²⁺‐Responsive Bimodal Magnetic Resonance Imaging and Fluorescence Imaging Agents and Their Interaction with Human Serum Albumin

Cited by 15 publications

References 43 publications

Versatile and Efficient Mechanochemical Synthesis of Crystalline Guest⊂Zeolitic Imidazolate Framework Complexes by in Situ Host–Guest Nanoconfinement

Versatile and Efficient Mechanochemical Synthesis of Crystalline Guest⊂Zeolitic Imidazolate Framework Complexes by in Situ Host–Guest Nanoconfinement

Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin

From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges

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Zn2+‐Responsive Bimodal Magnetic Resonance Imaging and Fluorescence Imaging Agents and Their Interaction with Human Serum Albumin

Cited by 15 publications

References 43 publications

Versatile and Efficient Mechanochemical Synthesis of Crystalline Guest⊂Zeolitic Imidazolate Framework Complexes by in Situ Host–Guest Nanoconfinement

Versatile and Efficient Mechanochemical Synthesis of Crystalline Guest⊂Zeolitic Imidazolate Framework Complexes by in Situ Host–Guest Nanoconfinement

Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin

From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges

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Zn²⁺‐Responsive Bimodal Magnetic Resonance Imaging and Fluorescence Imaging Agents and Their Interaction with Human Serum Albumin