Zn(<scp>ii</scp>) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction

Filipović, Nenad R.; Bjelogrlić, Snežana K.; Marinković, Aleksandar D.; Verbić, Tatjana Ž.; Cvijetić, Ilija N.; Senćanski, Milan; Rodić, Marko V.; Vujčić, Miroslava; Sladić, Dušan; Striković, Zlatko; Todorović, Tamara R.; Muller, Christian D.

doi:10.1039/c5ra19849f

Cited by 33 publications

(37 citation statements)

References 97 publications

(127 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its feature to accumulate in solid tumors raises interest of medicinal chemists to explore ability of newly synthesized compounds to bind to and use HSA as a carrier, and yields the rationale for developing the albumin-based drug delivery systems for tumor targeting drugs. 84 Here we explored performed experimental and docking analysis protocol to obtain information on selected TCH S2 interaction with HSA.…”

Section: Interaction Between S2 and Human Serum Albumin (Hsa)mentioning

confidence: 99%

Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

Božić

Marinković

Bjelogrlić³

et al. 2016

RSC Adv.

Self Cite

View full text Add to dashboard Cite

A comparative study of antitumor activity of mono-and bis-quinoline based (thio)carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells (AsPC-1). Thiocarbohydrazones (TCHs) revealed superior pro-apoptotic activity over carbohydrazones (CHs) on both tested cell phenotypes, also displaying multi-target profile activities. Programmed cell death triggered by TCHs was partially caspasedependent, mainly caspase-8 related. Activity against cancer stem cells (CSCs) was evaluated on 2D monolayers and 3D spheroidal models, where two out of three tested bis-TCHs successfully stimulated apoptosis accompanied by a reduction in size of treated spheres. Additionally, all bis-TCHs induced significant decrease in percentage of CD44-expressing AsPC-1 cells that indicate on their ability to induce reprogramming of CSC phenotype. Current results highly support further assessment of bisTCHs in order to specify their specific targets in cancer cells and particularly in the CSCs subpopulation.

show abstract

Section: Interaction Between S2 and Human Serum Albumin (Hsa)mentioning

confidence: 99%

Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

Božić

Marinković

Bjelogrlić³

et al. 2016

RSC Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

“…4a) shows one reduction peak at -1.72 V and one oxidation peak at 0.68 V. The reduction peak could be attributed to reduction of the thioamide bond. 57 The cathodic peak for selenoamide reduction is at -1.66 V, and two oxidation peaks at 0.20 and 0.95 V for H2qasesc (Fig. 4b).…”

Section: Cyclic Voltammetrymentioning

confidence: 95%

Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study

Djordjević

Vukašinović

Todorović

et al. 2017

JSCS

Self Cite

View full text Add to dashboard Cite

Cobalt(III) complexes derived from thio-and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio-and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD-DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated

show abstract

“…4, 5‐Dihydropyrazoles, a small bioactive molecule, are pre‐eminent structural design found in numerous pharmaceutically active compounds (antifungal, antibacterial, anti‐tumour, anti‐inflammatory and antiviral) and agrochemical active agents . The combination of transition metals with biologically active molecules has also been exploited showing promising activity due to their unique ability to bind different biological targets …”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological applications of some substituted pyrazoline based palladium (II) compounds

Thakor

Lunagariya

Bhatt

et al. 2018

Applied Organom Chemis

View full text Add to dashboard Cite

Palladium (II) complexes of the type [PdLCl 2 ] (where L = substituted pyrazoline ligands) have been synthesized. The metal complexes (5a-5f) have been characterized by various spectroscopic and analytical techniques like 1 H-NMR, 13 C-NMR, LC-MS, IR, Energy-dispersive X-ray (EDX), electronic spectroscopy, thermogravimetric analysis (TGA), elemental analysis and conductance measurement. Complexes to herring sperm DNA (HS-DNA) binding has been explored by absorption titration and binding constant (K b ) as well as Gibb's free energy have been evaluated. Complex 5b shows the highest binding constant value. So, thermodynamic parameters of 5b-HS DNA complex at different temperature have been evaluated. Also, Viscosity measurement and molecular modeling studies have been performed to know the binding mode of complexes. Based on the observations, an intercalative binding mode of DNA has been proposed. Further confirmation of intercalative mode of DNA binding has been taken by fluorescence spectroscopy and results are in a good agreement with absorption titration, viscosity measurement and molecular modeling data. Antibacterial activity of the complexes has been screened against pathogenic bacteria such as S. aureus, E. coli, B. subtilis, S. marcescens and P. aeruginosa. Cytotoxicity is performed on brine shrimp and S. pombe. Gel electrophoresis assay demonstrates that all the complexes can cleave the pUC19 plasmid DNA. Anti-tuberculosis activity has been carried out using mycobacterium tuberculosis H 37 Rv bacteria by L.J. Medium conventional method.

show abstract

Zn(ii) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction

Abstract: A new Zn(ii)-based complex shows a concentration-dependent apoptotic response in highly resistant pancreatic adenocarcinoma cells with extensive activation of caspase-8 and -9.

Cited by 33 publications

References 97 publications

Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study

Synthesis, characterization and biological applications of some substituted pyrazoline based palladium (II) compounds

Contact Info

Product

Resources

About