Zn(II)-Coordination Polymers with a Right- and Left-Handed Twist: Multifunctional Metal–Organic Hybrid for Dye Adsorption and Drug Delivery

Abstract

A relatively less explored bis-pyridyl-bis-amide ligand (L1) having a diphenylmethane backbone was exploited to generate a new series of coordination polymers as potential multifunctional materials. The reaction of L1 with ZnCl2, ZnBr2, CuCl2, and CoCl2 resulted in four coordination polymers, namely, CP1 [{Zn­(II)­(μ-L1)­(Cl) 2 }·H 2 O] ∝ , CP2 [{Zn­(II)­(μ-L1)­(Br) 2 }·H 2 O] ∝ , CP3 [{Cu­(II)­(μ-L1) 4 (Cl)}·Cl·H 2 O] ∝ , and CP4 [{Co­(II)­(μ-L1) 4 (Cl) 2 }] ∝ , which were characterized by single-crystal X-ray diffraction. While isomorphic CP1 and CP2 were one-dimensional (1D) coordination polymers displaying a right-handed and left-handed twist, respectively, CP3 displayed a three-dimensional coordination network having open channels that were occupied by chloride counterions and MeOH solvates. CP4, on the other hand, was a 1D looped chain coordination polymer. Both CP1 and CP2 were found to be a good adsorbent of organic dyes with an increased affinity toward anionic dyes. Powder X-ray diffraction studies revealed that the dye adsorption occurred at the surfaces. CP1 was also able to adsorb an anticancer drug, namely, doxorubicin hydrochloride, and deliver it to the target cancer cells MDA-MB-231 as revealed by a cell migration assay and cell imaging studies.

Zn(II)/Cd(II)-Based Metal–Organic Frameworks as Bifunctional Materials for Dye Scavenging and Catalysis of Fructose/Glucose to 5-Hydroxymethylfurfural

“…For example, the cationic/anionic nature of the MOFs are well-known for their selectivity toward anionic or cationic dyes by ion exchange, guest exchange, and/or host–guest interactions. Dye adsorption properties of the neutral framework is comparatively scant in the literature, and the present study comprised highly water-stable and functionally decorated neutral 2D Zn/Cd-based MOFs and their reversible adsorptive removal properties of dye molecules. − To investigate the efficiency for aqueous phase dye removal, we chose three positively charged dyes, methylene blue (MB), methyl violet (MV), rhodamine B (RhB), and a negatively charged dye, methyl orange (MO), as model pollutants for removal experiments by ADES- 4 and ADES- 5 possessing acylamide and hydroxyl functional groups in the dual ligand moiety (Scheme ).…”

A highly stable and efficient benzothiadiazole-based fluorescence sensor for salicylaldehyde in aqueous solution

“…As a class of inorganic-organic hybrid materials, coordination polymers (CPs) are widely used in chemical sensing, [12][13][14][15] gas adsorption 16,17 and separation, 18 catalysis, 19 and drug delivery. [20][21][22] Due to their good light absorption and electron transport properties, they can be used as ideal candidates for fluorescence sensing. CP-based fluorescence sensors have been of great interest in recent years because of the low cost, fast response, and high sensitivity and selectivity.…”

Conjugation of a Silver-Based Coordination Polymer with Curcumin: A New Case of an Inorganic Polymeric Co-crystal

“…Typically obtained by incorporating various metal centers (main-group metals, transition metals, and lanthanides) into an organic polymer backbone, MPs benefit from the properties of the polymeric frameworks and the functionalities of the metal centers, showing a notable range of applications in the field of material science, catalysis and bio-catalysis, environmental, and biomedicine. − Contextually, the field of MPs profited from the development of metal-mediated self-assembly as a tool to reach supramolecular metallopolymers. , The versatility of the strength and the number of metal–ligand interactions by varying the metal binding sites and the simple organic ligands has allowed the generation of one, two, or three-dimensional supramolecular metallopolymers, generally referred as coordination polymers (CPs), in particular, metal–organic frameworks (MOFs) or porous coordination polymers (PCPs) when porosity is present in the supramolecular network. , This new class of inorganic–organic hybrid materials has been recognized to possess a potential significant range of applications in antimicrobials, gas absorption and separation, luminescent materials, and drug delivery based on their different topologies and structures. − One-dimensional CPs, the simplest topological type of coordination arrangement, despite being considered the least structurally interesting, have received increasing attention due to the ease of synthesis and tunability of the resulting frameworks when compared to 3D CP structures . Moreover, 1D CPs have shown a rich range of applications depending on the metal ions and the simple coordinating organic ligands, working as luminescent probes, dye adsorbers, and drug delivery systems. − In the case of silver-based CPs, the modulation of the dimensionality is well related to the variable coordination number and flexible geometries reached by this metal ion. Silver coordination compounds have received great attention owing to their appealing properties, in particular, their interesting biological activities .…”