Zn(II) and Hg(II) complexes of naphthalene based thiosemicarbazone: Structure and spectroscopic studies

Basu, Arghya; Das, Gopal

doi:10.1016/j.ica.2011.01.097

Cited by 10 publications

(12 citation statements)

References 30 publications

(33 reference statements)

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“…Thus, it is presumed that C1 is likely to form an intermolecular hydrogen‐bonded supramolecular structure. The synthesis and characterization of the ligands and their metal complexes have been reported earlier …”

Section: Resultsmentioning

confidence: 99%

“…At a low concentration of C1, this Zn II ‐chelating effect thus has an overriding effect and prevents the formation of S. aureus biofilm. It has been observed in solid‐state X‐ray crystallographic studies of C1 that the ligand forms self‐assembled aggregates through various intermolecular H‐bonding modes, due to the presence of the thiourea moiety, and π‐stacking interactions, due to that of the naphthalene unit. Hence, it is envisaged that an increase in the concentration of C1 in solution could also result in the formation of the aggregated species.…”

Section: Resultsmentioning

confidence: 99%

“…The synthesis and characterization of the ligands and their metal complexes have been reported earlier. [23,24] Prior to determinationo ft he anti-biofilm potencies of the ligands, it was imperative to ascertain their activity against planktonicc ells of target bacteria. To pursue this goal, appropriate Gram-positivea nd Gram-negative bacteria weres elected and the antibacterial activities of the ligands and their metal complexes were tested.…”

Section: Resultsmentioning

confidence: 99%

“…Ligand and metal complexes : The synthesis and characterization of the ligands and their metal complexes have been reported earlier . Stock and working solutions of all the compounds were prepared in DMSO.…”

Section: Methodsmentioning

confidence: 99%

“…Ligand and metal complexes:T he synthesis and characterization of the ligands and their metal complexes have been reported earlier. [23,24] Stock and working solutions of all the compounds were prepared in DMSO. Stock solutions of each (20 mg mL À1 )w ere prepared and stored at room temperature under dark conditions.…”

Section: Methodsmentioning

confidence: 99%

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A Nonbactericidal Zinc‐Complexing Ligand as a Biofilm Inhibitor: Structure‐Guided Contrasting Effects on Staphylococcus aureus Biofilm

et al. 2017

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Zinc-complexing ligands are prospective anti-biofilm agents because of the pivotal role of zinc in the formation of Staphylococcus aureus biofilm. Accordingly, the potential of a thiosemicarbazone (compound C1) and a benzothiazole-based ligand (compound C4) in the prevention of S. aureus biofilm formation was assessed. Compound C1 displayed a bimodal activity, hindering biofilm formation only at low concentrations and promoting biofilm growth at higher concentrations. In the case of C4, a dose-dependent inhibition of S. aureus biofilm growth was observed. Atomic force microscopy analysis suggested that at higher concentrations C1 formed globular aggregates, which perhaps formed a substratum that favored adhesion of cells and biofilm formation. In the case of C4, zinc supplementation experiments validated zinc complexation as a plausible mechanism of inhibition of S. aureus biofilm. Interestingly, C4 was nontoxic to cultured HeLa cells and thus has promise as a therapeutic anti-biofilm agent. The essential understanding of the structure-driven implications of zinc-complexing ligands acquired in this study might assist future screening regimes for identification of potent anti-biofilm agents.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Nonbactericidal Zinc‐Complexing Ligand as a Biofilm Inhibitor: Structure‐Guided Contrasting Effects on Staphylococcus aureus Biofilm

et al. 2017

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The 4‐(Dimethylamino) benzaldehyde‐4‐ethylthiosemicarbazone as Ionophore for Mercury(II) Solid State Selective Electrode

Tahir¹,

Salhin²,

Saad³

et al. 2012

Electroanalysis

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Hg(II) has formed a soluble complex with 4‐(dimethylamino) benzaldehyde‐4‐ethylthiosemicarbazone (DMABET) in methanol with a molar ratio of mercury(II):DMABET of 1 : 4. The formation constant (Kf) and Gibbs free energy (▵G) of the complex showed that the formation of the complex was favorable. The DMABET was investigated as ionophore for Hg(II)‐ion selective electrode (ISE). At optimum pH 1–5 the proposed Hg(II)‐ISE showed an almost Nernstian slope at 27.8±1 mV, with linear regression coefficient, R2=0.995 and a detection limit of 5×10−6 M. There was no serious interference from silver(I) with selectivity coefficient 5.69×10−3. The electrode life span was more than 3 months. It has been applied for real water sample analysis and the results were in good agreement with the standard method.

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Iron(II) and cobalt(II) Complexes of 3,4‐Dihydroxybenzaldehyde‐4‐ethylthiosemicarbazone: Synthesis, Spectral Studies and Molecular Docking

Kayed

2023

ChemistrySelect

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Fe(II) and Co(II) complexes of 3,4‐dihydroxybenzaldehyde 4‐ethylthiosemicarbazone were synthesized and characterized by elemental analysis (CHNS), magnetic susceptibility measurements, molar conductivity, Fourier transform infrared (FT‐IR), nuclear‐magnetic resonance (1H‐NMR and 13C‐NMR) and ultraviolet‐visible (UV‐Vis) spectra. The spectral and analytical data revealed that the obtained thiosemicarbazone‐metal complexes have tetrahedral geometry around the metal center. The studied ligand acts as a bidentate ligand by using both azomethine nitrogen and thiol sulphur as monoanion center of donation. To predict the reactive sites for electrophilic and nucleophilic attack, the Molecular Electrostatic Potential (MEP) was determined. The antibacterial activities of 3,4‐dihydroxybenzaldehyde 4‐ethylthiosemicarbazone ligand and its complexes were tested by molecular docking technique into the crystal structure of topoisomerase II and topoisomerase IV proteins. Molecular docking investigation proved that, the ligand and its complexes had interesting interactions with active sites of amino acids of the target proteins. The Co(II) complex exhibited better potential inhibition than other studied compounds.

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Zn(II) and Hg(II) complexes of naphthalene based thiosemicarbazone: Structure and spectroscopic studies

Cited by 10 publications

References 30 publications

A Nonbactericidal Zinc‐Complexing Ligand as a Biofilm Inhibitor: Structure‐Guided Contrasting Effects on Staphylococcus aureus Biofilm

A Nonbactericidal Zinc‐Complexing Ligand as a Biofilm Inhibitor: Structure‐Guided Contrasting Effects on Staphylococcus aureus Biofilm

The 4‐(Dimethylamino) benzaldehyde‐4‐ethylthiosemicarbazone as Ionophore for Mercury(II) Solid State Selective Electrode

Iron(II) and cobalt(II) Complexes of 3,4‐Dihydroxybenzaldehyde‐4‐ethylthiosemicarbazone: Synthesis, Spectral Studies and Molecular Docking

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