Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I

Abstract

In this study, calcium phosphate materials were obtained via a simple, eco-friendly wet synthesis method using hen eggshells as a calcium source. It was shown that Zn ions were successfully incorporated into hydroxyapatite (HA). The obtained ceramic composition depends on the zinc content. When doped with 10 mol % of Zn, in addition to HA and Zn-doped HA, DCPD (dicalcium phosphate dihydrate) appeared and its content increased with the increase in Zn concentration. All doped HA materials exhibited antimicrobial activity against S. aureus and E. coli. Nevertheless, fabricated samples significantly decreased preosteoblast (MC3T3-E1 Subclone 4) viability in vitro, exerting a cytotoxic effect which probably resulted from their high ionic reactivity.

The Effect of Full-Scale Exchange of Ca2+ with Zn2+ Ions on the Crystal Structure of Brushite and Its Phase Composition

“…The results of the current study highlight the finding that the unique profile of platelike brushite crystals was conserved when the Zn/Ca ratio in the initial solutions did not surpass 0.25 [46]. Conversely, their dimensions declined because of the presence of Zn.…”

“…Conversely, their dimensions declined because of the presence of Zn. Zinc impedes the crystal growth of brushite [47]; hence, eventually, the brushite crystals The results of the current study highlight the finding that the unique profile of platelike brushite crystals was conserved when the Zn/Ca ratio in the initial solutions did not surpass 0.25 [46]. Conversely, their dimensions declined because of the presence of Zn.…”