Zn-doped etch-and-rinse model dentin adhesives: Dentin bond integrity, biocompatibility, and properties

Barcellos, Daphne Câmara; Fonseca, Beatriz Maria da; Pucci, César Rogério; Cavalcanti, Bruno das Neves; Persici, Erasmo De Souza; Gonçalves, Sérgio Eduardo de Paiva

doi:10.1016/j.dental.2016.04.003

Cited by 37 publications

(52 citation statements)

References 49 publications

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“…Zinc influences signaling pathways and stimulates a metabolic effect in hard tissue mineralization (Hoppe et al, 2011) and remineralization processes (Barcellos et al, 2016;Lynch et al, 2011). Zinc elicits a specific biological response at the interface of the material which results in the formation of a bond between tissue and material (Kokubo et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Toledano

Osorio

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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The aim of this study was to evaluate changes in the mechanical and chemical behavior, and bonding ability at dentin interfaces infiltrated with polymeric nanoparticles (NPs) prior to resin application. Dentin surfaces were treated with 37% phosphoric acid followed by application of an ethanol suspension of NPs, Zn-NPs or Ca-NPs followed by the application of an adhesive, Single Bond (SB). Bonded interfaces were stored for 24 h, submitted to microtensile bond strength test, and evaluated by scanning electron microscopy. After 24 h and 21 d of storage, the whole resin-dentin interface adhesive was evaluated using a Nano-DMA. Complex modulus, storage modulus and tan delta (δ) were assessed. AFM imaging and Raman analysis were performed. Bond strength was not affected by NPs infiltration. After 21 d of storage, tan δ generally decreased at Zn-NPs/resin-dentin interface, and augmented when Ca-NPs or non-doped NPs were used. When both Zn-NPs and Ca-NPs were employed, the storage modulus and complex modulus decreased, though both moduli increased at the adhesive and at peritubular dentin after Zn-NPs infiltration. The phosphate and the carbonate peaks, and carbonate substitution, augmented more at interfaces promoted with Ca-NPs than with Zn-NPs after 21 d of storage, but crystallinity did not differ at created interfaces with both ions-doped NPs. Crosslinking of collagen and the secondary structure of collagen improved with Zn-NPs resin-dentin infiltration. Ca-NPs-resin dentin infiltration produced a favorable dissipation of energy with minimal stress concentration trough the crystalline remineralized resin-dentin interface, causing minor damage at this structure.

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Section: Introductionmentioning

confidence: 99%

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Toledano

Osorio

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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“…Although the ZnO has been deeply investigated [ 20 , 21 , 23 – 25 , 28 ], ZnCl 2 was chosen to this study and added to model adhesive blend thanks to its higher solubility in water and ethanol than ZnO and to its fast rate of dissolution in Zn 2+ [ 20 ], which would make easier its incorporation into the adhesive. Also, in a previous pilot study carried out in this lab (unpublished data), it was observed that when added to the model adhesive this Zn salt produced less opaque solutions than ZnO blends, an aspect crucial to the polymerization behavior of the experimental adhesives [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, Barcellos et al [ 21 ] showed that the incorporation of 2, 5, and 10 wt.% of ZnO impaired the degree of conversion of model dentin adhesives, suggesting that this was due to a decrease in light penetration through the adhesives because of the high opacity of ZnO. According to these authors, this behavior could decrease the crosslink density and form structural defects in the cross-linked adhesive polymer, aspects highly deleterious to the clinical performance of adhesive systems.…”

Section: Discussionmentioning

confidence: 99%

“…The previous studies that have analyzed the effect of Zn salts on dentin bonding have added ZnO [ 21 , 23 – 25 ], ZnN 3 [ 22 ], Zn-methacrylate [ 21 ], and ZnCl 2 [ 23 , 24 , 28 ], inside commercially available [ 22 – 25 ] or experimental adhesive systems [ 21 ]. Among these, ZnCl 2 is the one that presents a very fast rate of dissolution [ 20 ] which may result in a higher saturation of Zn 2+ into the adhesive system.…”

Section: Introductionmentioning

confidence: 99%

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ZnCl₂ Incorporated into Experimental Adhesives: Selected Physicochemical Properties and Resin-Dentin Bonding Stability

Almeida

Silva

Guimarães

et al. 2017

BioMed Research International

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The aim of this study was to evaluate the degree of conversion (DC%), water sorption (WS), solubility (SO), and resin-dentin bonding stability of experimental adhesive systems containing ZnCl2. Different concentrations (wt.%) of ZnCl2 were added to a model etch-and-rinse adhesive system consisting of BISGMA, HEMA, UDMA, GDMA, water, and ethanol: Zn0 (0%-control group); Zn2 (2%); Zn3.5 (3.5%); and Zn5 (5%). Adper Single Bond 2 (SB) was used as commercial reference. The samples were light cured for 20s using a quartz-tungsten-halogen unit (650 mW/cm2). DC% (n = 5) was measured using FT-IR spectroscopy, and WS and SO (n = 5) were calculated based on ISO4049. Microtensile bond strength (μTBS) and nanoleakage (NL) were measured after 24 h and 12 months of water storage (n = 10). Data were analyzed using ANOVA and Tukey's HSD test (5%). Zn5 presented the lowest DC% and the highest WS and SO (p < 0.05). Zn0 and Zn2 presented statistically similar DC%, WS, SO, and immediate μTBS. All adhesives containing ZnCl2 maintained a μTBS stability after 12 months, but only Zn2 and Zn3.5 did not suffer an increase in NL. SB presented the highest immediate μTBS but the greatest reduction after 12 months (p < 0.05). The addition of 2 wt.% of ZnCl2 in adhesive formulations seems to be a promising way to improve the resin-dentin bonding stability. Higher concentrations than 2 wt.% could impair some physicochemical properties.

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“…According to Table 2, carboxylic acid-functionalized titanium dioxide (73), copper (74), silver (75), and zinc oxide (76) nanoparticles have been used to reinforce the organic matrix of resin adhesives, thus improving physico-mechanical properties of the material, and consequently, bond strength between the restoratives and dental substrates. In another study, by Lohbauer et al (77), zirconia nanoparticles were incorporated into the primer or adhesive of a commercial three-step etch-and-rinse adhesive system (SBMP, Scotchbond™ Multipurpose™, 3M ESPE, St. Paul, MN, USA), resulting in increased dentin bond strength.…”

Section: Resin Matrix Reinforcement With Fillers And/or Remineralizinmentioning

confidence: 99%

Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates

Münchow

Bottino

2017

Curr Oral Health Rep

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Purpose of review To present an overview on the main agents (i.e., biomolecules and nanocompounds) and/or strategies currently available to amplify or stabilize resin-dentin bonding. Recent findings According to studies retrieved for full text reading (2014–2017), there are currently six major strategies available to overcome resin-dentin bond degradation: (i) use of collagen crosslinking agents, which may form stable covalent bonds with collagen fibrils, thus strengthening the hybrid layer; (ii) use of antioxidants, which may allow further polymerization reactions over time; (iii) use of protease inhibitors, which may inhibit or inactivate metalloproteinases; (iv) modification of the bonding procedure, which may be performed by using the ethanol wet-bonding technique or by applying an additional adhesive (hydrophobic) coating, thereby strengthening the hybrid layer; (v) laser treatment of the substrate prior to bonding, which may cause specific topographic changes in the surface of dental substrates, increasing bonding efficacy; and (vi) reinforcement of the resin matrix with inorganic fillers and/or remineralizing agents, which may positively enhance physico-mechanical properties of the hybrid layer. Summary With the present review, we contributed to the better understanding of adhesion concepts and mechanisms of resin-dentin bond degradation, showing the current prospects available to solve that problematic. Also, adhesively-bonded restorations may be benefited by the use of some biomolecules, nanocompounds or alternative bonding strategies in order to minimize bond strength degradation.

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Zn-doped etch-and-rinse model dentin adhesives: Dentin bond integrity, biocompatibility, and properties

Abstract: The 1wt.% ZnOn may preserve the integrity of the hybrid layer and may reduce cytotoxicity and polymerization shrinkage of model dentin adhesive. The addition of Zn-Mt to the adhesive had no beneficial effects.

Cited by 37 publications

References 49 publications

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

ZnCl₂ Incorporated into Experimental Adhesives: Selected Physicochemical Properties and Resin-Dentin Bonding Stability

Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates

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Zn-doped etch-and-rinse model dentin adhesives: Dentin bond integrity, biocompatibility, and properties

Abstract: The 1wt.% ZnOn may preserve the integrity of the hybrid layer and may reduce cytotoxicity and polymerization shrinkage of model dentin adhesive. The addition of Zn-Mt to the adhesive had no beneficial effects.

Cited by 37 publications

References 49 publications

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

ZnCl2 Incorporated into Experimental Adhesives: Selected Physicochemical Properties and Resin-Dentin Bonding Stability

Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates

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Product

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About

ZnCl₂ Incorporated into Experimental Adhesives: Selected Physicochemical Properties and Resin-Dentin Bonding Stability