Ziziphus oenoplia Mill.: A Systematic Review on Ethnopharmacology, Phytochemistry and Pharmacology of an Important Traditional Medicinal Plant

Abstract

Background: Ziziphus oenoplia Mill. (Family- Rhamnaceae) an important shrub, often found throughout the hot regions of tropical Asia and northern Australia, is commonly well known as Jackal Jujube in English. It is a folk herbal medicine used as an abdominal pain killer and anti-diarrhoeal agent,. Objective: The review aims to provide up-to-date information on the vernacular information, botanical characterization, distribution, ethnopharmacological uses, pharmacological activities, and chemical constituents of Z. oenoplia for possible exploitation of treatment for various diseases and to suggest future investigations. Method: This review was performed by studying online resources relating to Z. oenoplia and diverse resources, including scientific journals, books, and worldwide accepted databases from which information was assembled to accumulate significant information and relevant data at one place. Results: Investigations on Z. oenoplia have been focused on its pharmacological activities, including its antimicrobial, antidiabetic, antihepatotoxic, antiulcer, antiplasmodial, anticancer, wound healing, anthelmintic, antioxidant, analgesic and antinociceptive, hypolipidemic activity, anti-inflammatory, immunomodulatory and antidiarrheal activities. Phytochemical studies resulted in the isolation of fatty acids, flavonoids, phenols, pentacyclic triterpenes, hydroxy carboxylic acids, aliphatic hydroxy ether, and cyclopeptide alkaloids. Conclusions: Most of the ethnopharmacological relevance of Z. oenoplia is justified but more need to be studied. Further investigations are necessary to fully understand the mode of action of the active constituents and to exploit its preventive and therapeutic potentials.

Medicinal plants from Gangetic plains of West Bengal and yoga for the management of lifestyle diseases

“…A departing shrub with tomentose branches; spines in different sized pairs; leaves alternate, ovate or ovate lanceolate having three main veins and several secondary veins; inflorescence cymes tomatose, in the axils of leaf, flowers very small, velvety tomentose, fruits small round to oval drupes. This plant is useful as antidiabetic, anticancer, antioxidant, analgesic and antinociceptive, hypolipidemic activity, antiinflammatory, immunomodulatory activities [40] . Results have been presented with photographs of the medicinal plants used in lifestyle diseases (Figure 1.).…”

Appraisal of Pancreatic Lipase Inhibitory Potential of Ziziphus oenoplia (L.)Mill. Leaves by In Vitro and In Silico Approaches

“…Around 431 compounds have been identified from various plant parts (including seeds, fruits, leaves, stems, and root bark) of Ziziphus spp., and most of them are alkaloids and flavonoids. , Ziziphus oenoplia (L.)­Mill. (Rhamnaceae) is one of the important medicinal plants of Ziziphus genera with an incredible pharmacological profile exhibiting antimicrobial, antidiabetic, hypolipidemic,anti-inflammatory, immunomodulatory, anticancer, hepatoprotective, wound healing, and antiulcer activities . In the present study, the petroleum ether, ethyl acetate, ethanolic, and water were used as solvents to prepare respective extracts of Ziziphus oenoplia (L.)­Mill.…”

“…(Rhamnaceae) is one of the important medicinal plants of Ziziphus genera with an incredible pharmacological profile exhibiting antimicrobial, antidiabetic, hypolipidemic,anti-inflammatory, immunomodulatory, anticancer, hepatoprotective, wound healing, and antiulcer activities. 39 In the present study, the petroleum ether, ethyl acetate, ethanolic, and water were used as solvents to prepare respective extracts of Ziziphus oenoplia (L.)Mill. leaves, and the proposed bioactivity was successfully assessed at a preliminary level using a combination of in vitro and in silico approaches,with a credible outcome.…”