Ziziphine N, O, P and Q, New Antiplasmodial Cyclopeptide Alkaloids from Ziziphus oenoplia var. brunoniana.

Suksamrarn, Sunit; Suwannapoch, Narisara; Aunchai, Natthachai; Kuno, Mayuso; Ratananukul, Piniti; Haritakun, Rachada; Jansakul, Chawewan; Ruchirawat, Somsak

doi:10.1002/chin.200524189

Cited by 12 publications

(16 citation statements)

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“…Zizyphus lotus (L.) is a Mediterranean species resistant to moderate cold and hot weather, able to vegetate in a dry atmosphere and be content with low rainfall 16 . The different species of Ziziphus are widely used in the treatment of certain diseases such as inflammatory diseases, digestive disorders, weakness, liver diseases, obesity, urinary disorders, diabetes, skin infections, fever, diarrhea and insomnia 20,21 .…”

Section: Introductionmentioning

confidence: 99%

In vitro litholytic activity of extracts and phenolic fractions of some medicinal plants on urinary stones

et al. 2020

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Objective: This study was carried out to evaluate the efficiency of plant extracts used in traditional medicine on the dissolution of oxalo-calcic and cystine stones. Also, the efficiency of phenolic fractions (Tannins and Flavonoids) for the plants that gave us the best stone dissolution rate. Subjects and methods: Kidney stone of oxalo-calcic and cystine stones were incubated in vitro for 8 weeks in the presence of five plants extracts (hydro-ethanolic and aqueous extracts). NaCl solution (0,9 %) used as negative control and sodium citrate solution at 3 mM/L as a positive control. The studied plants were Herniaria hirsuta L. aerial parts, Opuntia ficus-indica L. flowers, Zea mays L. stigmata, Ammi visnaga L. seeds and Ziziphus lotus L. fruits. After 2, 4, 6 and 8 weeks the stones were weighed after 18 h drying at 40°C and the dissolution rate of the stones and the pH of the solution were measured.Results: After eight weeks, all the plant extracts and phenolic fractions had revealed a significant effect to dissolve oxalo-calcic and cystine stones in comparison to the control solutions. The best result of cystine stones was showed with aqueous extract of H. hirsuta aerial parts which had a dissolution rate of 88,91 %. Concerning the dissolution rate of oxalo-calcic stones the aqueous extract of Z. mays had the best results with 68 % against 19 % for the sodium citrate solution. The dissolution rate of the fractions studied showed a better result for Z. mays flavonoids fraction toward oxalo-calcic stones, and Z. mays tannins fraction for cystine stones. The pH undergoes a non-negligible linear increase over the eight weeks for all extracts and phenolic fractions and both kidney stones.Conclusion: The tested plants' extracts and the phenolic fractions for the plants that gave us the best stone dissolution rate were able to dissolve oxalo-calcic and cystine stones. To confirm the efficiency of these plant extracts on the treatment of oxalo-calcic and cystine stones multiple in vivo tests could be made.

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Section: Introductionmentioning

confidence: 99%

In vitro litholytic activity of extracts and phenolic fractions of some medicinal plants on urinary stones

et al. 2020

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“…Garcinia adalah salah satu genus dari famili Guttiferae (manggis-manggisan) yang kaya dengan senyawa fenol tipe flavonoid, santon, dan benzofenon (Minami, Hamaguchi, Kubo, & Fukuyama, 1998;Baggett et al, 2005;Lannang et al, 2005). Golongan senyawa ini diketahui memiliki aktivitas biologis yang beraneka ragam seperti antioksidan, antimikroba, sitotoksik, dan antimalaria (Suksamrarn et al, 2003;Hay et al, 2004;Ito et al, 2001).…”

Section: Pendahuluanunclassified

SENYAWA STEROID DARI AKAR TUMBUHAN ASAM KANDIS (Garcinia Cowa) SEBAGAI OBAT PENURUN DEMAM

Darwati¹,

Nurlelasari²,

Mayanti³

2019

j.penelit.has.kehutan

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Garcinia cowa is belong to the Guttiferae family. In Indonesia this plant is locally named asam kandis. Traditionally, the stem bark of Garcinia cowa are used as antipyretic dan antimicroba, the fruits and leaves used as expectorat, and laxative, and the roots is used for fever medicine. The variaty use are Garcinia cowa as traditional medicine is based it chemical compounds. In our continuing phytochemical investigation to found the secondary metabolite compounds of Garcinia plants found in Indonesia, The objective of this research was to find the steroid compound from the roots of Garcinia cowa. Isolation was conducted by extraction and chromatography methods. The structure of this compound was determined based on spectroscopic data from NMR and comparison with the reported data.

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“…This supported the 5S,8S,9S-configuration. A weak vicinal coupling between H-8 and H-9 (J = 3.2 Hz) suggests a trans orientation (Suksamrarn et al, 2005). To confirm the configuration, acid hydrolysis of 1 was performed.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Jubanines F–J, cyclopeptide alkaloids from the roots of Ziziphus jujuba

et al. 2015

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Five Ib-type cyclopeptide alkaloids, jubanines F-J (1-5), and three known compounds, nummularine B (6), daechuine-S3 (7), and mucronine K (8) were isolated from the roots of Ziziphus jujuba. Their structures were fully characterized by spectroscopic analyses in combination with chemical derivatization. Compounds 1-3, and 6 were evaluated for their antiviral activity against the porcine epidemic diarrhea virus (PEDV). Compounds 2, 3, and 6 showed potent inhibitory effects on PEDV replication.

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Ziziphine N, O, P and Q, New Antiplasmodial Cyclopeptide Alkaloids from Ziziphus oenoplia var. brunoniana.

Cited by 12 publications

References 1 publication

In vitro litholytic activity of extracts and phenolic fractions of some medicinal plants on urinary stones

In vitro litholytic activity of extracts and phenolic fractions of some medicinal plants on urinary stones

SENYAWA STEROID DARI AKAR TUMBUHAN ASAM KANDIS (Garcinia Cowa) SEBAGAI OBAT PENURUN DEMAM

Jubanines F–J, cyclopeptide alkaloids from the roots of Ziziphus jujuba

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