Zirconium oxide coating improves implant osseointegration in vivo

Sollazzo, Vincenzo; Pezzetti, Furio; Scarano, Antonio; Piattelli, Adriano; Bignozzi, Carlo Alberto; Massari, Leo; Brunelli, Giorgio; Carinci, Francesco

doi:10.1016/j.dental.2007.06.003

Cited by 166 publications

(110 citation statements)

References 16 publications

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“…The first generation is called inert ceramics, which aimed to substitute natural bone. For example, zirconia [49][50][51][52], titanium [53][54][55] and alumina [56][57][58] are primarily used in fabrication of femoral heads to substitute the damaged bones [59]. Although these ceramics are biocompatible, the living body usually reacts against the implants because they are foreign, and these implants themselves are likely to never transform into bone.…”

Section: Evolution Of Bioceramics In Hard Tissue Engineeringmentioning

confidence: 99%

A review of protein adsorption on bioceramics

et al. 2012

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Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic -protein interactions.

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Section: Evolution Of Bioceramics In Hard Tissue Engineeringmentioning

confidence: 99%

A review of protein adsorption on bioceramics

et al. 2012

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“…ZrO 2 coatings and films for biomedical application have also attracted much attention. It was reported that ZrO 2 films fabricated by micro arc oxidation [19] and plasma spraying [20] were bioactive in vitro, and ZrO 2 coating prepared by dip coating in colloidal suspension can improve dental implant osteointegration in vivo in rabbits [21].…”

Section: Introductionmentioning

confidence: 99%

Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

Zhang

Sun

et al. 2012

Biointerphases

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Cathodic arc deposition technique was used to deposit zirconia (ZrO2) films and titania (TiO2) films on titanium (Ti) disks respectively. The surface topography was characterized by scanning electron microscopy and atomic force microscopy. The element composition of the films was detected by X-ray photoelectron spectroscopy. The phase of films was identified by thin film X-ray diffraction. The biological behavior of osteoblast-like MG63 cells cultured on Ti, TiO2 and ZrO2 was investigated and the possible signaling molecules involved was studied by the gene expressions of integrin β1, extracellular related kinase 1/2 (ERK1/2), and c-fos. The results indicated that both the TiO2 and ZrO2 films were amorphous. Scanning electron microscopy study showed that the adhesion of MG63 cells on TiO2 and ZrO2 films was significantly enhanced compared to Ti. The CCK8 assay indicated that the TiO2 and ZrO2 films promoted the proliferation of MG-63 cells. The alkaline phosphatase (ALP) activity test and the production of type collagen I (COLI) by immunofluorescence showed that both the TiO2 and ZrO2 films can enhance ALP activity and COLI expression of MG-63 cells. In addition, the ALP activity on ZrO2 films was higher than on TiO2 films at day 4, which indicate ZrO2 films may lead to promotion of a more osteoblastic phenotype of MG-63 cells than TiO2 films. Real-time polymerase chain reaction analysis demonstrated that The gene expression of integrin β1, ERK1/2, and c-fos was higher on TiO2 and ZrO2 films than on Ti. The present work suggests that the amorphous ZrO2 films produced by cathodic arc deposition may be favorable for orthopedic implant applications and worth further study.

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“…9,18,19 Moreover, when the surface treatment increased bone-implant contact, the likelihood of osseointegration increased. 11 However, the high pullout resistance of implants with treated surfaces compared with those having machined surfaces suggests that the surface influences initial stability even when osseointegration does not occur.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the dental implant is an object of study by several researchers [7][8][9][10][11] whose goals are to develop design innovations and application techniques to optimize the implant's physical-chemical and mechanical properties. 7 One current area of research involves the treatment of implant surfaces for osseointegration stimulation due to a chemical or micromorphological alteration of the implant 9 that can facilitate early inDeclaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”

Section: Introductionmentioning

confidence: 99%

In vitro analysis of the influence of surface treatment of dental implants on primary stability

et al. 2012

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In vitro analysis of the influence of surface treatment of dental implants on primary stability Abstract: Surface treatment interferes with the primary stability of dental implants because it promotes a chemical and micromorphological change on the surface and thus stimulates osseointegration. This study aimed to evaluate the effects of different surface treatments on primary stability by analyzing insertion torque (IT) and pullout force (PF). Eight samples of implants with different surface treatments (TS -external hexagon with acid surface treatment; and MS -external hexagon, machined surface), all 3.75 mm in diameter × 11.5 mm in length, were inserted into segments of artificial bones. The IT of each sample was measured by an electronic torquemeter, and then the pullout test was done with a universal testing machine. The results were subjected to ANOVA (p < 0.05), followed by Tukey's test (p < 0.05). The IT results showed no statistically significant difference, since the sizes of the implants used were very similar, and the bone used was not highly resistant. The PF values (N) were, respectively, TS = 403.75 ± 189.80 and MS = 276.38 ± 110.05. The implants were shown to be different in terms of the variables of maximum force (F = 4.401, p = 0.0120), elasticity in maximum flexion (F = 3.672, p = 0.024), and relative stiffness (F = 4.60, p = 0.01). In this study, external hexagonal implants with acid surface treatment showed the highest values of pullout strength and better stability, which provide greater indication for their use.

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Zirconium oxide coating improves implant osseointegration in vivo

Cited by 166 publications

References 16 publications

A review of protein adsorption on bioceramics

A review of protein adsorption on bioceramics

Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

In vitro analysis of the influence of surface treatment of dental implants on primary stability

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