Zirconium immune-complexes for PET molecular imaging: Current status and prospects

Meléndez‐Alafort, Laura; Ferro‐Flores, Guillermina; Nardo, L. De; Ocampo‐García, Blanca; Bolzati, Cristina

doi:10.1016/j.ccr.2022.215005

Cited by 10 publications

(7 citation statements)

References 270 publications

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“…[78] However, PET is usually inflexible in terms of target specificity and isotopes are characterized by short cycle times, the need for repeated administration and high doses, which can trigger serious adverse effects. [79] To overcome these problems, a new strategy for labeling synthesis has been proposed, whereby radioactive precursors are added during the synthesis of nanoparticles. For example, the introduction of radioisotopes (e. g., 64 Cu, 44 Sc, and 57 Co) was achieved by incorporating them into the crystal structure of LDH.…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ma,

Chen,

Qiao

2024

The Chemical Record

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Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist of orthorhombic arrays of metal hydroxides with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced drug bioavailability, LDHs have many potential applications in the medical field. Especially in the fields of bioimaging and tumor therapy. This paper reviews the research progress of LDHs and their nanocomposites in the field of tumor imaging and therapy. First, the structure and advantages of LDH are discussed. Then, several commonly used methods for the preparation of LDH are presented, including co‐precipitation, hydrothermal and ion exchange methods. Subsequently, recent advances in layered hydroxides and their nanocomposites for cancer imaging and therapy are highlighted. Finally, based on current research, we summaries the prospects and challenges of layered hydroxides and nanocomposites for cancer diagnosis and therapy.

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Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ma,

Chen,

Qiao

2024

The Chemical Record

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“…In recent years, desferrioxamine B has become the chelator of choice to label in particular antibodies with Zirkonium-89 ( 89 Zr) for Positron Emission Tomography (PET), so-called immuno-PET imaging [ 90 ]. The reported in vivo release of 89 Zr from the desferrioxamine B chelator has stimulated research to develop more stable chelators for PET imaging applications [ 91 ]. Among the developments, the use of FsC as scaffold to attach targeting vectors such as peptides has shown promising results to construct multimeric targeting probes for Gallium-68 ( 68 Ga) and 89 Zr labeling [ 92–94 ], as well as 68 Ga-labeled probes for hybrid imaging [ 95 ] and pretargeting [ 96 ] applications.…”

Section: Translational Aspects Of the Fungal Siamentioning

confidence: 99%

Fungal siderophore metabolism with a focus on Aspergillus fumigatus: impact on biotic interactions and potential translational applications

Happacher,

Aguiar,

Yap

et al. 2023

Essays in Biochemistry

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Iron is an essential trace element that is limiting in most habitats including hosts for fungal pathogens. Siderophores are iron-chelators synthesized by most fungal species for high-affinity uptake and intracellular handling of iron. Moreover, virtually all fungal species including those lacking siderophore biosynthesis appear to be able to utilize siderophores produced by other species. Siderophore biosynthesis has been shown to be crucial for virulence of several fungal pathogens infecting animals and plants revealing induction of this iron acquisition system during virulence, which offers translational potential of this fungal-specific system. The present article summarizes the current knowledge on the fungal siderophore system with a focus on Aspergillus fumigatus and its potential translational application including noninvasive diagnosis of fungal infections via urine samples, imaging of fungal infections via labeling of siderophores with radionuclides such as Gallium-68 for detection with positron emission tomography, conjugation of siderophores with fluorescent probes, and development of novel antifungal strategies.

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“…Due to the size and biodistribution time of bigger biomolecules like antibodies, radionuclides with longer half-lives are also required in PET imaging. Radiometals like zirconium-89 (half-life of 78.41 h) and copper-64 (half-life of 12.7 h) have thus been used for PET imaging of antibodies and antibody fragments. , Unlike labeling with fluorine-18, labeling with radiometals is usually more straightforward. It requires the modification of the biomolecules with a chelating group (e.g., desferrioxamine (DFO) for zirconium-89 or tetraazacyclododecane tetraacetic acid (DOTA) for copper-64) prior to the labeling step, with both reactions being carried out under mild and aqueous conditions.…”

Section: Introductionmentioning

confidence: 99%

“…12.7 h) have thus been used for PET imaging of antibodies and antibody fragments. 2,13 Unlike labeling with fluorine-18, labeling with radiometals is usually more straightforward. It requires the modification of the biomolecules with a chelating group (e.g., desferrioxamine (DFO) for zirconium-89 or tetraazacyclododecane tetraacetic acid (DOTA) for copper-64) prior to the labeling step, with both reactions being carried out under mild and aqueous conditions.…”

Section: ■ Introductionmentioning

confidence: 99%

Fluorine-18 and Radiometal Labeling of Biomolecules via Disulfide Rebridging

Richard,

Martin Aubert,

Denis

et al. 2023

Bioconjugate Chem.

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Biomolecules labeled with positron-emitting radionuclides like fluorine-18 or radiometals like copper-64 and zirconium-89 are increasingly employed in nuclear medicine for diagnosis purposes. Given the fragility and complexity of these compounds, their labeling requires mild conditions. Besides, it is essential to develop methods inducing minimal modification of the tertiary structure, as it is fundamental for the biological activity of such complex entities. Given these requirements, disulfide rebridging represents a promising possibility since it allows protein modification as well as conservation of the tertiary structure. In this context, we have developed an original radiofluorinated dibromopyridazine dione prosthetic group for labeling of disulfide-containing biomolecules via rebridging. We employed it to radiolabel octreotide, a somatostatin analogue, and to radiolabel fragment antigen binding (Fab) targeting programmed death-ligand 1 (PD-L1), whose properties were then evaluated in vitro and in vivo by positron emission tomography (PET) imaging. We next extended our strategy to the radiolabeling of cetuximab, a monoclonal antibody, with various radiometals commonly used in PET imaging (zirconium-89, copper-64) by developing various rebridging molecules bearing the appropriate chelators. The stabilities of the radiolabeled antibody conjugates were assessed in biological conditions.

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Zirconium immune-complexes for PET molecular imaging: Current status and prospects

Cited by 10 publications

References 270 publications

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Fungal siderophore metabolism with a focus on Aspergillus fumigatus: impact on biotic interactions and potential translational applications

Fluorine-18 and Radiometal Labeling of Biomolecules via Disulfide Rebridging

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