Zirconium and hafnium 1994

Page, E. M.; Wass, Sherilyn A.

doi:10.1016/0010-8545(96)01278-7

Cited by 6 publications

(3 citation statements)

References 132 publications

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“…The distances between the Zr 4+ ions of each monomer subunit and the bridging O atom were observed to be 1.9809(3)Å, while the Zr–O–Zr angle was observed to be 167.32(7)°. These values are similar to published literature describing other Zr-μ-oxo complexes, and several observations may explain these results. − The pyridyl ring of the PCTA ligand most likely increases the rigidity and preorganization of the resulting Zr-PCTA complex. In addition, numerous inter- and intramolecular hydrogen bonding motifs are observed in the solid state.…”

Section: Resultssupporting

confidence: 89%

Polyazamacrocycle Ligands Facilitate ⁸⁹Zr Radiochemistry and Yield ⁸⁹Zr Complexes with Remarkable Stability

et al. 2020

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Over the last three decades, the chemistry of zirconium has facilitated antibody development and the clinical management of disease in the precision medicine era. Scientists have harnessed its reactivity, coordination chemistry, and nuclear chemistry to develop antibody-based radiopharmaceuticals incorporating zirconium-89 ( 89 Zr: t 1/2 = 78.4 h, β + : 22.8%, E β+max = 901 keV; EC: 77%, E γ = 909 keV) to improve disease detection, identify patients for individualized therapeutic interventions. and monitor their response to those interventions. However, release of the 89 Zr 4+ ion from the radiopharmaceutical remains a concern, since it may confound the interpretation of clinical imaging data, negatively affect dosimetric calculations, and hinder treatment planning. In this report, we relate our novel observations involving the use of polyazamacrocycles as zirconium-89 chelators. We describe the synthesis and complete characterization of zirconium 2,2′,2″,2‴-(1,4,7,10-tetraazacyclotridecane-1,4,7,10-tetrayl)tetraacetic acid (Zr-TRITA), zirconium 3,6,9, pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (Zr-PCTA), and zirconium 2,2′,2″-(1,4,7-triazacyclononane-1,4,7-triyl)triacetic acid (Zr-NOTA). In addition, we elucidate the solid-state structure of each complex using single-crystal X-ray diffraction analysis. Finally, we found that [ 89 Zr]Zr-PCTA and [ 89 Zr]Zr-NOTA demonstrate excellent stability in vitro and in vivo and provide a rationale for these observations. These innovative findings have the potential to guide the development of safer and more robust immuno-PET agents to improve precision medicine applications.

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Section: Resultssupporting

confidence: 89%

Polyazamacrocycle Ligands Facilitate ⁸⁹Zr Radiochemistry and Yield ⁸⁹Zr Complexes with Remarkable Stability

et al. 2020

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“…Zirconium (II) complexes are known, but they typically require p-donor ligands to enhance stability even under inert atmosphere conditions, and even fewer reports describing the Zirconium (III) oxidation state exist. A significant portion of knowledge regarding this element’s reactivity has been extrapolated from hafnium (Hf) chemistry since their atomic and ionic properties yield similar chemistries with a variety of ligands, and much of what is known about zirconium coordination chemistry has been discovered in the context of solid-state material or catalysis development [ 52 , 53 ]. While research in these areas has provided numerous societal benefits including heat and corrosion resistant coatings; fracture resistant ceramics; and the development of catalysts that play a role in the petroleum, plastics, and pharmaceutical industries, it has been difficult to translate this knowledge into the research fields of radiochemistry and molecular imaging.…”

Section: Zirconium Chemistry and The Production Of Zirconium-89mentioning

confidence: 99%

Recent Advances in Zirconium-89 Chelator Development

2018

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The interest in zirconium-89 (89Zr) as a positron-emitting radionuclide has grown considerably over the last decade due to its standardized production, long half-life of 78.2 h, favorable decay characteristics for positron emission tomography (PET) imaging and its successful use in a variety of clinical and preclinical applications. However, to be utilized effectively in PET applications it must be stably bound to a targeting ligand, and the most successfully used 89Zr chelator is desferrioxamine B (DFO), which is commercially available as the iron chelator Desferal®. Despite the prevalence of DFO in 89Zr-immuno-PET applications, the development of new ligands for this radiometal is an active area of research. This review focuses on recent advances in zirconium-89 chelation chemistry and will highlight the rapidly expanding ligand classes that are under investigation as DFO alternatives.

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“…Further reduction could be achieved by surface chemistry, by, stimulated detaching of the Cl ions. Lower oxidation states have also been achieved by synthetic chemistry 40 – 42 . Alternatively, atomic manipulation/metalation could also be a viable method to construct such Pcs directly on the surface, starting from non metal H 2 Pc derivatives, and exploiting the capability of STM tips to pick and deposit single atoms to construct atomic aggregates with tailored geometries 43 .…”

Section: Resultsmentioning

confidence: 99%

Designing a molecular magnetic button based on 4d and 5d transition-metal phthalocyanines

Ferriani

Heinze

Bellini

2017

Sci Rep

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The field of molecular spintronics exploits the properties of organic molecules possessing a magnetic moment, either native in the form of radicals or induced by the insertion of transition metal magnetic ions. To realize logic or storage molecular spin-tronics devices, molecules with stable different magnetic states should be deposited on a substrate, and switching between the states controllably achieved. By means of a first-principles calculations, we have devised a functional molecule exhibiting different magnetic states upon structural changes induced by current injection. We investigate the prototypical case of non-planar M-Phthalocyanine (MPc), where M is a transition-metal ion belonging to the 4d and 5d series. We find that for ZrPc and HfPc deposited on a graphene decorated Ni(111) substrate, two different structural conformations could be stabilized, for which the molecules attain different magnetic states depending on the position of the M ion – whether above the Pc or between the Pc and the substrate –, acting therefore as molecular magnetic button. Our work indicates an intuitive way to engineer a magnetic molecular switch with tailored properties, starting from the knowledge of the basic atomic properties of elements and surfaces.

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Zirconium and hafnium 1994

Cited by 6 publications

References 132 publications

Polyazamacrocycle Ligands Facilitate ⁸⁹Zr Radiochemistry and Yield ⁸⁹Zr Complexes with Remarkable Stability

Polyazamacrocycle Ligands Facilitate ⁸⁹Zr Radiochemistry and Yield ⁸⁹Zr Complexes with Remarkable Stability

Recent Advances in Zirconium-89 Chelator Development

Designing a molecular magnetic button based on 4d and 5d transition-metal phthalocyanines

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Zirconium and hafnium 1994

Cited by 6 publications

References 132 publications

Polyazamacrocycle Ligands Facilitate 89Zr Radiochemistry and Yield 89Zr Complexes with Remarkable Stability

Polyazamacrocycle Ligands Facilitate 89Zr Radiochemistry and Yield 89Zr Complexes with Remarkable Stability

Recent Advances in Zirconium-89 Chelator Development

Designing a molecular magnetic button based on 4d and 5d transition-metal phthalocyanines

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Product

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Polyazamacrocycle Ligands Facilitate ⁸⁹Zr Radiochemistry and Yield ⁸⁹Zr Complexes with Remarkable Stability

Polyazamacrocycle Ligands Facilitate ⁸⁹Zr Radiochemistry and Yield ⁸⁹Zr Complexes with Remarkable Stability