Zirconia based composite scaffolds and their application in bone tissue engineering

Sivasankar, M.V.; Chinta, Madhavi Latha; Sreenivasa Rao, P.

doi:10.1016/j.ijbiomac.2024.130558

Cited by 3 publications

(2 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11,12 Metal materials have poor biocompatibility and are difficult to degrade. 13,14 Interestingly, polyesters such as poly ( degradation, and fatigue-resistance characteristics which are suitable for the preparation of scaffolds. 5,15,16 However, POC elastomers have poor bioactivity, and their degradation products have also been reported to lower local pH, triggering an inflammatory response.…”

Section: ■ Introductionmentioning

confidence: 99%

“…A variety of biomaterials, including hydrogel, metal, and polyester, have been widely used in tissue engineering. Among them, hydrogels are characterized by weak mechanical strength and rapid degradation, making them insufficient to support tissue repair. , Metal materials have poor biocompatibility and are difficult to degrade. , Interestingly, polyesters such as poly(3-caprolactone) (PCL), poly(lactic acid) (PLA), and poly(1,8-octanediol- co -citrate) (POC) have the advantages of good biocompatibility, excellent mechanical properties, controllable degradation, and fatigue-resistance characteristics which are suitable for the preparation of scaffolds. ,, However, POC elastomers have poor bioactivity, and their degradation products have also been reported to lower local pH, triggering an inflammatory response. − This drawback could hinder their widespread application in tissue engineering. − Therefore, to address these issues, the combination of POC with glycine-modified nanoclay has been introduced for the first time.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanoclay Reinforced Integrated Scaffold for Dual-Lineage Regeneration of Cartilage and Subchondral Bone

Yin,

Xia,

Fan

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Tissue engineering is theoretically considered a promising approach for repairing osteochondral defects. Nevertheless, the insufficient osseous support and integration of the cartilage layer and the subchondral bone frequently lead to the failure of osteochondral repair. Drawing from this, it was proposed that incorporating glycine-modified attapulgite (GATP) into poly(1,8octanediol-co-citrate) (POC) scaffolds via the one-step chemical cross-linking is proposed to enhance cartilage and subchondral bone defect repair simultaneously. The effects of the GATP incorporation ratio on the physicochemical properties, chondrocyte and MC3T3-E1 behavior, and osteochondral defect repair of the POC scaffold were also evaluated. In vitro studies indicated that the POC/10% GATP scaffold improved cell proliferation and adhesion, maintained cell phenotype, and upregulated chondrogenesis and osteogenesis gene expression. Animal studies suggested that the POC/10% GATP scaffold has significant repair effects on both cartilage and subchondral bone defects. Therefore, the GATP-incorporated scaffold system with dual-lineage bioactivity showed potential application in osteochondral regeneration.

show abstract