This study provides relevant data on the granodiorite in southern Zhuguangshan, South China Block (SCB), including mineralogical information, zircon U-Pb ages, zircon Hf isotope data, whole-rock geochemical data, and Sr-Nd-Pb isotopic data. These data indicate that the granodiorite in southern Zhuguangshan crystallized at approximately 448.7 Ma. The hornblende and micas of the granodiorites are magnesio-hornblende and Mg-rich biotite, respectively. The granodiorite samples are characterized by relatively high SiO 2 contents of 61.72-66.19 wt.%, K 2 O contents of 3.77-5.18 wt.%, Na 2 O contents of 2.42-3.16 wt.%, low FeO T contents of 3.93-5.79 wt.%, and relatively high MgO contents of 1.78-2.55 wt.%, with Mg # values (molar Mg/[Mg + Fe] Â 100) of 43-50. The contents of rare earth elements (REEs)in the granodiorite specimens are 166-283 ppm, and the REEs show both a chondrite-normalized REE pattern that inclines rightward and slightly negative Eu anomalies (0.62-0.90). The Fuxi granodiorite is rich in large-ion lithophile elements (LILEs; Rb, Th, U, and K) but is depleted in high-field-strength elements (HFSEs; Nb, Ta, and Ti). All the samples have similar Sr-Nd-Pb and zircon Hf isotopic compositions and have a ( 87 Sr/ 86 Sr) i ratio of 0.707319-0.710888, a ( 143 Nd/ 144 Nd) i ratio of 0.511705-0.511760, a ( 206 Pb/ 204 Pb) t ratio of 17.918-18.459, a ( 207 Pb/ 204 Pb) t ratio of 15.711-15.813, and a ( 208 Pb/ 204 Pb) t ratio of 37.953-38.563. The ε Nd (t) and ε Hf (t) values range from À7.12 to À5.88 and from À9.81 to À4.45, respectively, with corresponding two-stage Nd model ages of 1.66-1.76 Ga and two-stage Hf model ages of 1.55-1.78 Ga. These findings indicate that the granodiorite is magnesian andesite and that the magmas are derived from a mixture of crustal and mantle materials. Based on these findings in combination with previous research results, it can be concluded that the mantle beneath the Cathaysia Block was moderately depleted during the Early Palaeozoic and that Early Palaeozoic magmatism may be related to Early Palaeozoic oceanic crust subduction.