Ziprasidone, a second-generation antipsychotic drug, triggers a macrophage inflammatory response in vitro

Duarte, Thiago; Barbisan, Fernanda; Prado-Lima, Pedro Antônio Schmidt do; Azzolin, Verônica Farina; Jung, Ivo Emilio da Cruz; Teixeira, Cibele Ferreira; Mastella, Moisés Henrique; Cruz, Ivana Beatrice Mânica da

doi:10.1016/j.cyto.2017.10.017

Cited by 17 publications

(9 citation statements)

References 26 publications

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“…A recent study has shown that aripiprazole can suppress inflammatory responses triggered by Gram positive bacteria through suppression of both AP-1 and NF-κB pathways ( 33 ). Ziprasidone was found to trigger a macrophage inflammatory response in vitro ( 34 ). Quetiapine has been associated with high rates of constipation ( 35 ) and constipation may be associated with microbiota dysbiosis ( 36 , 37 ).…”

Section: Resultsmentioning

confidence: 99%

C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review

et al. 2018

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Objectives: The objective of this systematic review was to synthetize the published data on the relationships between elevated blood C-reactive protein (CRP) levels and schizophrenia (SZ) onset risk, illness characteristics and treatments, cognition and physical health.Method: The systematic bibliographic searches have been carried out according to the Cochrane methodology. Medline, web of science, Google Scholar with each database being searched from inception to November 2017.Results: 53 studies were included in the present review. While meta-analyses including case-control studies suggest a clear association between CRP and SZ, one other study has suggested that CRP-associated genes were associated with a lower risk of SZ onset. Increased CRP has been significantly associated with positive symptoms in acute phase psychosis, while studies including community-dwelling stabilized subjects did not find such an association. Abnormal CRP has been associated with a wide range of cognitive impairment in SZ stabilized individuals. Body Mass index has been extensively associated with increased CRP in SZ subjects; and increased CRP has been identified as a risk factor for metabolic syndrome and cardiovascular risk in SZ subjects. Increased CRP has also been associated with high nicotine dependence in SZ smokers and one study has suggested that increased CRP was associated with sedentary behavior.Conclusion: In the light of the above-mentioned studies, increased hs-CRP may be reasonably suggested as a marker for SZ onset risk, as well as a risk factor for increased positive symptoms, cognitive impairment, hypovitaminosis D, microbiota disturbances, cardiovascular and metabolic syndrome risk in SZ subjects, and increased nicotine dependence in SZ smokers. In case of increased CRP levels, anti-inflammatory strategies (add-on anti-inflammatory drugs including aspirin and omega 3 fatty acids, vitamin D supplementation, physical activity, probiotics) should be also further evaluated.Limits: Most of the studies were cross-sectional and cohort studies are needed to determine the temporal relationship between increased CRP and the psychiatric outcomes.

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Section: Resultsmentioning

confidence: 99%

C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review

et al. 2018

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“…INF-γ is a small polypeptide that regulates cell function. It plays an important role in cell-mediated immune regulation ( 19 ). On the one hand, INF-γ stimulates the production of macrophages.…”

Section: Discussionmentioning

confidence: 99%

Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication

et al. 2018

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Levels of D-dimer and interferon-γ (INF-γ) in pediatric patients with Mycoplasma pneumoniae pneumonia (MPP) were assessed to explore its clinical implication in evaluating the disease severity and patients' prognosis. Enrolled in this study as subjects were 185 pediatric patients with MPP who were admitted to the Department of Pediatrics of the Second Affiliated Hospital of Qiqihar Medical University and the First Hospital of Qiqihar City from January 2017 to October 2017 and 115 healthy children who underwent physical examination during the same time period. Patients were divided into two groups according to the severity of their pneumonia: Severe pneumonia group with 95 patients and mild pneumonia group with 90 patients. A total of 92 healthy children were assigned to the control group. Immunoassay was performed to measure the serum levels of D-dimer and INF-γ. The levels of these two markers were compared. In terms of D-dimer, the levels in pediatric patients in pneumonia groups were all higher than that in the healthy children (p<0.0001). After treatment for 120 h, the D-dimer and INF-γ levels in both pneumonia groups were lower than those before treatment (p<0.001). Among the patients in both the mild and severe pneumonia groups, those who developed extra-pulmonary complications had higher levels of D-dimer and INF-γ than those who did not developed extra-pulmonary complications (p<0.001). Increased levels of D-dimer and INF-γ were observed in pediatric patients with MPP. Assessment of the levels of D-dimer and INF-γ in serum may help with the diagnosis of severe MPP in children and predicting the occurrence of complications. This study provided more theoretical basis for the early diagnosis and identification of MPP in children, and can be used as a guideline in evaluating the severity and preventing complications.

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“…All protocols performed were similar to previously described studies by Barbisan et al [22] and Duarte et al [23] of in vitro psychotropic drug effects on macrophage inflammatory response. Macrophages are highly sensitive to antigens and other antigenic factors, which induce intense cellular proliferation and morphological changes.…”

Section: Methodsmentioning

confidence: 99%

Lithium is able to minimize olanzapine oxidative-inflammatory induction on macrophage cells

et al. 2019

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BackgroundOlanzapine (OLZ) is a second-generation antipsychotic drug used for treatment of schizophrenia, bipolar disorder, and other neuropsychiatric conditions. Undesirable side effects of OLZ include metabolic alterations associated with chronic oxidative-inflammation events. It is possible that lithium (Li), a mood modulator that exhibits anti-inflammatory properties may attenuate OLZ-induced oxi-inflammatory effects.MethodologyTo test this hypothesis we activated RAW 264.7 immortalized macrophages with OLZ and evaluated oxidation and inflammation at the gene and protein levels. Li and OLZ concentrations were determined using estimated plasma therapeutic concentrations.ResultsOLZ triggered a significant increase in macrophage proliferation at 72 h. Higher levels of oxidative markers and proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6, with a concomitant reduction in IL-10, were observed in OLZ-exposed macrophages. Lithium (Li) exposure triggered a short and attenuated inflammatory response demonstrated by elevation of superoxide anion (SA), reactive oxygen species (ROS), IL-1β, and cellular proliferation followed by elevation of anti-inflammatory IL-10 levels. Li treatment of OLZ-supplemented macrophages was able to reverse elevation of oxidative and inflammatory markers and increase IL-10 levels.ConclusionsDespite methodological limitations related to in vitro protocols, results suggested that Li may attenuate OLZ-induced oxidative and inflammatory responses that result from metabolic side effects associated with OLZ.

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Ziprasidone, a second-generation antipsychotic drug, triggers a macrophage inflammatory response in vitro

Cited by 17 publications

References 26 publications

C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review

C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review

Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication

Lithium is able to minimize olanzapine oxidative-inflammatory induction on macrophage cells

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