Zipper-like series of desmosomes supported by subplasmalemmal actin belts in thymic epithelial reticular cells in the rat

Rusu, Mugurel Constantin; Pop, F.; Mănoiu, Valentina Mariana; Lupuşoru, Mircea; Didilescu, Andreea Cristiana

doi:10.1016/j.aanat.2013.02.007

Cited by 3 publications

(7 citation statements)

References 23 publications

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“…Individual segments are about 190 nm long and 100 nm wide, the intercellular space measuring 30 nm (Figure 6(h) and Figure S1B). With this arrangement these intercellular contacts are reminiscent of serial desmosomes described as “zipper‐like desmosomes” by Rusu et al (2013) in epithelial cells of the thymus. Apart from these special desmosomes the contact areas in the epiblast rosettes are equipped with interdigitating cell membranes accompanied by few tight junctions (Figure 6(b)).…”

Section: Resultsmentioning

confidence: 83%

“…Arrows point to variant types of mitochondria. (e and h) Special immature desmosomes between ventral epiblast cells; black filled‐in arrowheads mark the microfilaments and the contoured black arrowheads mark the intermediate filaments in according to Rusu et al, 2013. (f) Discontinuity in the basement membrane between epiblast and hypoblast.…”

Section: Resultsmentioning

confidence: 99%

“…Filopodia fill the inner surface of the cavity. (g) Special mature trilogy desmosomes between ventral epiblast cells; contoured black arrowheads mark the intermediate filaments in according to Rusu et al, 2013. (h) Extracellular matrix of basement membrane is located peripherally of the embryonic disc border.…”

Section: Resultsmentioning

confidence: 99%

“…White open arrowheads refer to tight junctions. (b') Box in B mark high magnification of special desmosomes (zipper‐like desmosomes); black filled‐in arrowheads mark the microfilaments and the contoured black arrowheads mark the intermediate filaments in according to Rusu et al, 2013. (c) The fusing of mural trophoblast with epithelialized epiblast anteriorly.…”

Section: Resultsmentioning

confidence: 99%

“…The rearrangement and organization of the ventral epiblast cells from the ball shape into an epithelialized sheet of cells requires extraordinary mechanical stability, which may be provided by the immature version of the zipper‐like type of desmosomes between the ventral epiblast cells. Already at the immature stage these desmosomes are covered by the dense felt of actin microfilaments before they eventually develop into what is known as zipper‐like desmosomes (Rusu et al, 2013). The special immature desmosomes are similar to what is called young desmosomes with their lack of a dense midline (Brooke et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Epiblast and trophoblast morphogenesis in the pre‐gastrulation blastocyst of the pig. A light‐ and electron‐microscopical study

Harmoush

Tsikolia

Viebahn

2021

Journal of Morphology

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The epiblast of the amniote embryo is of paramount importance during early development as it gives rise to all tissues of the embryo proper. In mammals, it emerges through segregation of the hypoblast from the inner cell mass and subsequently undergoes transformation into an epithelial sheet to create the embryonic disc. In rodents and man, the epiblast cell layer is covered by the polar trophoblast which forms the placenta. In mammalian model organisms (rabbit, pig, several non‐human primates), however, the placenta is formed by mural trophoblast whereas the polar trophoblast disintegrates prior to gastrulation and thus exposes the epiblast to the microenvironment of the uterine cavity. Both, polar trophoblast disintegration and epiblast epithelialization, thus pose special cell‐biological requirements but these are still rather ill‐understood when compared to those of gastrulation morphogenesis. This study therefore applied high‐resolution light and transmission electron microscopy and three‐dimensional (3D) reconstruction to 8‐ to 10‐days‐old pig embryos and defines the following steps of epiblast transformation: (1) rosette formation in the center of the ball‐shaped epiblast, (2) extracellular cavity formation in the rosette center, (3) epiblast segregation into two subpopulations ‐ addressed here as dorsal and ventral epiblast ‐ separated by a “pro‐amniotic” cavity. Ventral epiblast cells form between them a special type of desmosomes with a characteristic dense felt of microfilaments and are destined to generate the definitive epiblast. The dorsal epiblast remains a mass of non‐polarized cells and closely associates with the disintegrating polar trophoblast, which shows morphological features of both apoptosis and autophagocytosis. Morphogenesis of the definitive epiblast in the pig may thus exclude a large portion of bona fide epiblast cells from contributing to the embryo proper and establishes contact de novo with the mural trophoblast at the junction between the two newly defined epiblast cell populations.

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Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Epiblast and trophoblast morphogenesis in the pre‐gastrulation blastocyst of the pig. A light‐ and electron‐microscopical study

Harmoush

Tsikolia

Viebahn

2021

Journal of Morphology

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CD146- and CD105-positive phenotypes of retinal ganglion cells. Are these in situ proofs of neuronal regeneration?

et al. 2014

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Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology

et al. 2022

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Tumor lysis syndrome (TLS) is a common cause of acute kidney injury in patients with malignancies, and it is a frequent condition for which the nephrologist is consulted in the case of the hospitalized oncological patient. Recognizing the patients at risk of developing TLS is essential, and so is the prophylactic treatment. The initiation of treatment for TLS is a medical emergency that must be addressed in a multidisciplinary team (oncologist, nephrologist, critical care physician) in order to reduce the risk of death and that of chronic renal impairment. TLS can occur spontaneously in the case of high tumor burden or may be caused by the initiation of highly efficient anti-tumor therapies, such as chemotherapy, radiation therapy, dexamethasone, monoclonal antibodies, CAR-T therapy, or hematopoietic stem cell transplantation. It is caused by lysis of tumor cells and the release of cellular components in the circulation, resulting in electrolytes and metabolic disturbances that can lead to organ dysfunction and even death. The aim of this paper is to review the scientific data on the updated definition of TLS, epidemiology, pathogenesis, and recognition of patients at risk of developing TLS, as well as to point out the recent advances in TLS treatment.

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Zipper-like series of desmosomes supported by subplasmalemmal actin belts in thymic epithelial reticular cells in the rat

Cited by 3 publications

References 23 publications

Epiblast and trophoblast morphogenesis in the pre‐gastrulation blastocyst of the pig. A light‐ and electron‐microscopical study

Epiblast and trophoblast morphogenesis in the pre‐gastrulation blastocyst of the pig. A light‐ and electron‐microscopical study

CD146- and CD105-positive phenotypes of retinal ganglion cells. Are these in situ proofs of neuronal regeneration?

Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology

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