2023
DOI: 10.3390/cells12141852
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Zingiber officinale-Derived Extracellular Vesicles Attenuate Bleomycin-Induced Pulmonary Fibrosis Trough Antioxidant, Anti-Inflammatory and Protease Activity in a Mouse Model

Abstract: Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe idiopathic interstitial pneumonia. It is a chronic and progressive disease with a poor prognosis and is a major cause of morbidity and mortality. This disease has no cure; therefore, there is a clinical need to search for alternative treatments with greater efficacy. In this study, we aimed to evaluate the effect of extracellular vesicles (EVs) from Zingiber officinale (EVZO) in a murine model of bleomycin (BLM)-induced IPF administered throug… Show more

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“…SOD catalyzes the breakdown of superoxide radicals, a primary contributor to oxidative stress in IPF. 102 By enhancing the delivery of antioxidant enzymes to the sites of oxidative stress, exosomes offer a localized and efficient strategy to neutralize harmful free radicals and mitigate oxidative damage. 103 Another facet of exosome-mediated oxidative stress management in IPF is the transfer of regulatory RNA molecules, including miRNAs and lncRNAs.…”
Section: Application Of Exosomes In Oxidative Stress Management In Ipfmentioning
confidence: 99%
“…SOD catalyzes the breakdown of superoxide radicals, a primary contributor to oxidative stress in IPF. 102 By enhancing the delivery of antioxidant enzymes to the sites of oxidative stress, exosomes offer a localized and efficient strategy to neutralize harmful free radicals and mitigate oxidative damage. 103 Another facet of exosome-mediated oxidative stress management in IPF is the transfer of regulatory RNA molecules, including miRNAs and lncRNAs.…”
Section: Application Of Exosomes In Oxidative Stress Management In Ipfmentioning
confidence: 99%