Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes

Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Kandemir, Fatih Mehmet

doi:10.1016/j.cbi.2023.110410

Cited by 28 publications

(11 citation statements)

References 78 publications

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“…Apoptotic factors activate the caspase cascade. 36,38,39 Kandemir et al reported that Caspase-3 is critical to the development of the apoptosis process and is a key step in this process. 36 In the presented study, it was determined that oral administration of CYP increased Caspase-3 activity, and administration of QUE together with CYP decreased the expression of these genes and reduced apoptosis.…”

Section: Evaluation Of Histopathological Resultsmentioning

confidence: 99%

Kuersetin'in Sipermetrin Kaynaklı Mide Hasarı Üzerine Etkileri: Oksidatif Stres, Enflamasyon ve Apoptozun Rolü

Akaras

Gür

Şimşek

et al. 2023

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi

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This study was conducted to investigate the effects of quercetin (QUE) on cypermethrin (CYP) induced gastrotoxicity in rats. 35 Sprague-Dawley rats were randomly divided into five groups, 7 in each group. In the study, 25 and 50 mg/kg QUE were administered orally 30 min after 25 mg/kg cypermethrin was administered to rats for 28 days. Oxidative stress, inflammation, ER stress, apoptosis and autophagy markers were biochemically analyzed in gastric tissues. Additionally, histological analysis was performed for microscopic evaluation of gastric tissue. The results revealed that QUE prevented tissue damage by reducing CYP-induced lipid peroxidation (MDA) and increasing GSH, SOD, CAT and GPx activities. It also showed anti-inflammatory effect by suppressing inflammatory markers such as NF-𝜅B, IL-1β, TNF-α, iNOS and COX-2. QUE administration down-regulated CYP-induced increased PERK, ATF6, Caspase-3 and Beclin-1 markers. In addition, administration of QUE ameliorated the pathological tissue damage in gastric tissue due to CYP. The data of this study show that Que suppresses CYP-induced gastric toxicity by reducing oxidative stress, inflammation, ER stress, apoptosis a autophagy.

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Section: Evaluation Of Histopathological Resultsmentioning

confidence: 99%

Kuersetin'in Sipermetrin Kaynaklı Mide Hasarı Üzerine Etkileri: Oksidatif Stres, Enflamasyon ve Apoptozun Rolü

Akaras

Gür

Şimşek

et al. 2023

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi

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“…[ 53 ] The effect of ROS is attenuated by defence system consisting of enzymatic or nonenzymatic antioxidant components such as SOD, CAT, GPx, and GSH, which are effective in reducing oxidative stress damage. [ 26,54 ] Testicular tissue is highly susceptible to ROS‐induced oxidative stress, and oxidative stress has a direct impact on the phases of spermatogenesis. [ 55 ] Aksu et al have reported that COL causes oxidative stress damage in testicular tissue by raising oxidant MDA and reducing the levels of antioxidant enzymes SOD, CAT, GPx, and GSH in testicular tissue.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of naringin on colistin‐induced damage in rat testicular tissue: Modulating the levels of Nrf‐2/HO‐1, AKT‐2/FOXO1A, Bax/Bcl2/Caspase‐3, and Beclin‐1/LC3A/LC3B signaling pathways

Kankılıç,

Şimşek,

Akaras

et al. 2024

J Biochem & Molecular Tox

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Antimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of the drugs used in the treatment of multidrug‐resistant bacteria resulting in toxic effects. Naringin (NRG), a natural flavonoid, has come to the fore as its antioxidant, anti‐inflammatory, and antiapoptotic activities. The aim of the present study was to determine whether NRG has protective effects on COL‐induced toxicity in testicular tissue. Thirty‐five male Spraque rats were randomly divided into five groups (n = 7 per group): Control, COL, NRG, COL + NRG 50, COL + NRG 100. COL (15 mg/kg b.w., i.p., once per/day), and NRG (50 or 100 mg/kg, oral, b.w./once per/day) were administered for 7 days. The parameters of oxidative stress, inflammation, apoptosis, and autophagic damage were evaluated by using biochemical, molecular, western blot, and histological methods in testicular issues. NRG treatment reversed the increased malondialdehyde level and reduced antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione) levels due to COL administration (p < 0.001), and oxidative stress damage was mitigated. Nuclear factor erythroid 2‐related factor‐2 pathway, one of the antioxidant defence systems, was stimulated by NRG (p < 0.001). NRG treatment reduced the levels of markers for the pathways of apoptotic (p < 0.001) and autophagic (p < 0.001) damages induced by COL. Sperm viability and the live/dead ratio were reduced by COL but enhanced by NRG treatment. Testicular tissue integrity was damaged by COL but showed a tendency to improve by NRG. In conclusion, COL exhibited toxic effect on testicular tissue by elevating the levels of oxidative stress, apoptosis, autophagy, inflammation, and tissue damage. NRG demonstrated a protective effect by alleviating toxic damage.

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“…Since MDA is the end product of polyunsaturated fatty acids, it is the strongest indicator of oxidative stress [31]. There are defense systems consisting of enzymatic and nonenzymatic anti-oxidant components to reduce the effect of oxidants in the Some enzymes such as SOD, CAT, and GPx are some of the anti-oxidant enzymes involved in the removal of ROS from cells [34]. GSH removes radical species such as superoxide radicals and hydrogen peroxide from the cell and protects membrane protein thiols [35].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats

AKARAS,

KANDEMİR,

ŞİMŞEK

et al. 2023

Türk Doğa Ve Fen Dergisi

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Aim: Long-term exposure to sodium valproate, an antiepileptic drug, causes toxic effects in tissues, especially by increasing oxidative stress and inflammation. Rutin is a flavanoid with antioxidant, anti-inflammatory and antiapoptotic effects found naturally in many plants. In this study, we aimed to investigate the effects of rutin, a natural antioxidant, on sodium valproate-induced spleen tissue damage. Materials and Methods: 35 male rats were divided into 5 groups as control, sodium valproate, rutin, sodium valproate+Rutin 50 and sodium valproate+Rutin 100 groups. For 14 days, 500 mg/kg dose of sodium valproate and 50 or 100 mg/kg of rutin were administered by oral gavage. On day 15, spleen tissues were removed and biochemical methods, oxidative stress, inflammation and apoptotic parameters were analyzed and histologic analysis was performed. Results: The levels of sodium valproate-induced oxidative stress, inflammation and apoptosis parameters increased in spleen tissues compared to the control group (p

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Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes

Cited by 28 publications

References 78 publications

Kuersetin'in Sipermetrin Kaynaklı Mide Hasarı Üzerine Etkileri: Oksidatif Stres, Enflamasyon ve Apoptozun Rolü

Kuersetin'in Sipermetrin Kaynaklı Mide Hasarı Üzerine Etkileri: Oksidatif Stres, Enflamasyon ve Apoptozun Rolü

Protective effects of naringin on colistin‐induced damage in rat testicular tissue: Modulating the levels of Nrf‐2/HO‐1, AKT‐2/FOXO1A, Bax/Bcl2/Caspase‐3, and Beclin‐1/LC3A/LC3B signaling pathways

Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats

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