Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats

Türk, Erdinç; Güvenç, Mehmet; Cellat, Mustafa; Uyar, Ahmet; Kuzu, Müslüm; Ağgül, Ahmet Gökhan; Kirbaş, Akın

doi:10.1080/01480545.2020.1804397

Cited by 27 publications

(14 citation statements)

References 52 publications

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“…Lipid peroxidation causes decrease in membrane uidity and impairment of membrane function (Kuzu et al 2019). Formation of MDA is considered as one of the main markers of oxidative stress (Türk et al 2020). In the study, it was observed that the MDA level increased signi cantly in the OVA treated group compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

Cellat

Kuzu

İşler

et al. 2021

Naunyn-Schmiedeberg's Arch Pharmacol

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Asthma is an in ammatory disease that affects many people around the world, especially individuals of pediatric age. The effectiveness of tyrosol, a natural phenolic compound, was examined in the asthma model induced by ovalbumin (OVA). MethodsFor this purpose, 4 groups, each consisting of 8 rats, were formed. Serum physiological was given to the control group for 21 days. OVA was given to OVA, OVA + Dexamethasone (Dexa) and OVA + tyrosol groups intraperitoneally and by inhalation. Additionally, 0.25 mg/kg Dexa was administered to the OVA + Dexa group and 20 mg/kg tyrosol to the OVA + Tyrosol group by oral gavage. Serum, blood, BALF uid and lung tissues of the rats were examined. Resultsit was observed that the MDA level decreased, GSH level and GPx activity increased, and there was no change in CAT activity in the tyrosol treatment groups. It was also observed that NF-κB, TNF-α, IL-4, IL-5, IL-13, IFN-, and IgE levels decreased compared to the OVA group. However, no effect on IL-1 β level was observed. In addition, it was determined that tyrosol treatment increased the IL-10 level. The results of the histopathological investigation of lung tissue showed that tyrosol signi cantly ameliorated OVA-induced histopathological lesions. Additionally, PAS staining showed that mucus hypersecretion was signi cantly reduced with the use of tyrosol. In addition, it was determined that the number of eosinophils decreased signi cantly. ConclusionsThe obtained results showed that tyrosol presented antioxidant and anti-in ammatory features on OVAinduced rats and preserved tissue architecture.

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Section: Discussionmentioning

confidence: 99%

Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

Cellat

Kuzu

İşler

et al. 2021

Naunyn-Schmiedeberg's Arch Pharmacol

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“…However, the intensity of these elevations of the markers and Cd accumulation were encountered in the presence of ZGO administration. Researchers have shown that ZGO has a powerful nephroprotective effect against toxicants that cause kidney injury 17,18 . Furthermore, the reduction in Cd level in kidney tissue following ZGO treatment may be due to the capability of ZGO to improve the synthesis of metallothionein and enhance the execration of Cd from the kidney 19 .…”

Section: Discussionmentioning

confidence: 99%

Zingerone alleviates cadmium-induced nephrotoxicity in rats via its antioxidant and anti-apoptotic properties

Dawood

Mumtaz

Padiya

2022

Rev. Ciênc. Farm. Básica Apl.

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Objectives: Cadmium is an essential industrial metal and acts as an environmental toxicant that is a major cause of kidney diseases. Hence, we aimed to evaluate the possible nephroprotective effects of zingerone (ZGO), a major flavonoid constituent in ginger (Zingiber officinale) dry roots, against cadmium-induced nephrotoxicity in rats. Methods: In this study, Wistar albino rats [ACUC: HU2020/Z/FMS0120-01] were allocated randomly to 4 groups with seven animals in each group. The control group which received physiological saline; cadmium chloride (CdCl 2 ) treatment group which received CdCl 2 at a dose of 6.5 mg/kg intraperitoneally (i.p.) for 7 consecutive days; zingerone treatment group which received 25 mg/kg of zingerone orally for 7 consecutive days and CdCl 2 (6.5 mg/kg; i.p.)+ZGO (25 mg/kg; p.o.) treatment group which received CdCl 2 and ZGO for 7 consecutive days. Results: Co-administration of ZGO along with CdCl 2 resulted in a significant reduction in creatinine and urea levels of serum. Additionally, ZGO significantly diminished the tissue levels of Cd concentration, lipid peroxidation, and nitric oxide and significantly recovered the enzymatic and nonenzymatic antioxidant molecules, namely glutathione, total superoxide dismutase, catalase, and glutathione recycling enzymes peroxidase and reductase, in kidney tissue. Furthermore, ZGO treatment prevented the inflammation produced by CdCl 2 by restraining the elevation in the level of pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta). Moreover, ZGO improved histopathological alternations in the kidney by preventing apoptosis cascade in kidney tissue by stimulating Bcl-2 and suppressing Bax and caspase-3. Conclusions: Our findings suggest that ZGO has nephroprotective activity in cadmium-induced nephrotoxicity mostly via modulating of oxidant/antioxidant balance, inflammatory response, and apoptosis.

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“…[60] It has been reported that increased levels of ALT and AST in the serum indicate liver dysfunction due to structural defect in hepatocytes while urea and creatine levels indicate renal dysfunction. [61] Serum ALT, AST, urea, and creatinine levels were examined to determine whether safranal treatment had a toxic effect. According to the findings, these values increased in the groups in which RA was formed.…”

Section: Notementioning

confidence: 99%

Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats

Cellat

İşler

Kutlu

et al. 2022

J Biochem & Molecular Tox

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Rheumatoid arthritis (RA) is a systemic chronic disease characterized by inflammation and synovitis. More effective treatment methods with less side effects need to be developed. In this context, current study investigated the therapeutic effects of safranal in a model of complete Freund's adjuvant (CFA)‐induced RA. The control group was given 1 ml of saline orally starting from the 8th day, and 0.2 ml of CFA was given to the RA, RA + Safranal and RA + Methotrexate (MTX) groups on the 0th day of the experiment. Starting from the 8th day of the experiment, 1 ml of saline was given to the RA group, safranal was given at 200 mg/kg of body weight to the RA + MTX group, and 3 mg/kg of MTX to the RA + MTX group twice a week. The results showed that weight gain decreased in the RA group compared to the control group while arthritis index score, thymus index, and planter temperature were found to be increased. Additionally, a deterioration in blood parameters, an increase in alanine aminotransferase, aspartate aminotransferase, urea, creatinine, C‐reactive protein, and malondialdehyde levels, and a decrease in reduced glutathione levels and glutathione peroxidase and catalase (CAT) activities were seen while tumor necrosis factor‐α, interleukin‐6 (IL‐6), cyclooxygenase‐2, nuclear factor kappa B levels were found to be increased. However, the safranal had a regulatory effect on all the values, except IL‐6 and CAT, and blood parameters. Moreover, histopathological examination revealed that safranal reduced inflammatory cell infiltration and edema.

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Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats

Cited by 27 publications

References 52 publications

Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

Zingerone alleviates cadmium-induced nephrotoxicity in rats via its antioxidant and anti-apoptotic properties

Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats

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