Zingerone protects against cisplatin-induced oxidative damage in the jejunum of Wistar rats

Rehman, Muneeb U.; Ahmad, Bilal; Ahmad, Arif; Rasool, Saiema; Farooq, Adil; Razzaq, Rahil; Bhat, Showkat Ahmad; Bashir, Sumaira; Shabir, Ovais; Amin, Insha; Masoodi, Mubashir Hussain; Mir, Manzoor Ur Rahman; Shah, Mohammed Yaseen

doi:10.1007/s13596-015-0187-5

Cited by 14 publications

(6 citation statements)

References 48 publications

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“…Induction of apoptotic signaling pathway is reported to worsen seizure-induced brain damage resulting in extended epileptic seizures. In reaction to seizure-stimulated brain injury, permeabilization of mitochondria happens and proapoptotic proteins are secreted from mitochondria, leading to downstream executioner caspase (caspase-3) activation causing brain lesions [58]. Evidence suggests that there is cross-talk between oxidative stress and mitochondrial dysfunction followed by apoptosis in seizure-induced neural damage, making both changes in mitochondria and oxidative stress elements for epileptogenesis [59].…”

Section: Discussionmentioning

confidence: 99%

Zingerone Targets Status Epilepticus by Blocking Hippocampal Neurodegeneration via Regulation of Redox Imbalance, Inflammation and Apoptosis

et al. 2021

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Epilepsy is an intricate neurological disease where the neurons are severely affected, leading to the mortality of millions worldwide. Status epilepticus (SE), induced by lithium chloride (LiCl) and pilocarpine, is the most accepted model for epilepsy. The current work aims to unravel the mechanisms underlying the anti-epileptic efficacy of zingerone (an active ingredient of ginger), which has beneficial pharmacological activities on seizure-induced behavioral, histological, neurochemical, and molecular patterns in mice. Zingerone restored cognitive function by diminishing seizure activity, escape latency, and subsequent hippocampal damage manifested in histology. Seizures are associated with local inflammation, redox imbalance, and neural loss, confirmed by the present study of SE, and was attenuated by zingerone treatment. Nuclear factor-kappa B and its downstream signaling molecules (TNF-α, IL-1β, IL-6, NO, MPO) were activated in the LiCl-and-pilocarpine-induced group leading to inflammatory signaling, which was substantially ameliorated by zingerone treatment. The intrinsic apoptotic process was triggered subsequent to SE, as demonstrated by augmentation of cleaved caspase-3, downregulation of Bcl-2. However, zingerone treatment downregulated caspase-3 and upregulated Bcl-2, increasing cell survival and decreasing hippocampal neural death, deciphering involvement of apoptosis in SE. Therefore, zingerone plays an essential role in neuroprotection, probably by precluding oxidative stress, inflammation, and obstructing the mitochondrial pathway of apoptosis.

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Section: Discussionmentioning

confidence: 99%

Zingerone Targets Status Epilepticus by Blocking Hippocampal Neurodegeneration via Regulation of Redox Imbalance, Inflammation and Apoptosis

et al. 2021

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“…This protective effect against cisplatininduced toxicity probably might be through the attenuation of oxidative stress and inflammation. Besides, that it aids in maintaining antioxidant and suppresses activation of redox-active transcription factor NFκB [10].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, they have anti-viral, antiinflammatory, and anti-bacterial properties, as well as cancer prophylaxis [5][6][7][8]. Zingerone, an essential oil, extracted from natural product ginger that was reported to have various biological functions including antiapoptotic and antioxidant effects through interfering with the inflammatory pathway leading to a protective effect [9,10].…”

Section: Introductionmentioning

confidence: 99%

Zingerone Alleviate Toxicity Induced by Cisplatin or Gamma Radiation in Rats by Modulating Pro-Inflammatory Mediators

Abdel-Hamid¹,

Abdel-Aziz²,

Anany³

2021

JCRCT

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Background: Zingerone is one of the active components of ginger that possesses multiple biological activities and anti-inflammatory properties against either radiation effect or cisplatin toxicity. Purpose: to examine the protective effect of zingerone against gamma radiation (IR) or cisplatin-induced immunotoxicity. Material and Methods: 48 rats were divided into six groups as follows: (group-1); normal control group received distilled water; (group-2); rats received Zingerone orally at a dose of 25 mg/kg b.wt. Once / day for 14 consecutive days (Zing.). (group-3); Rats were given a single injection of Cisplatin at a dose of 7.5 mg/kg b.wt. intraperitoneally (Cispl.). (group-4); Rats exposed to a single dose of 6 Gy whole-body gamma irradiation using 137Cesium source in a Gamma cell 40 (Rad.). (group-5); rats received same dose of Zingerone then they were exposed to gamma radiation as in group 4 (Zing+Rad.). (group-6); rats received Zingerone followed by single injection of Cisplatin at the dose of 7.5 mg/kg b.wt. Intraperitoneally (Zing+Cisp.). Results: Exhibited a significant increase in expression of NF-κB, IL-10, caspase-3, and gene expression of TNF-α as well as oxidative stress biomarkers (MDA and NO) levels accompanied with a reduced level of SOD in either whole body-irradiated or cisplatin-received group. Conversely, pro-inflammatory cytokines levels were significantly decreased with an improvement of oxidative stress in groups that received zingerone. Conclusion: It could be concluded that zingerone exerts its antioxidative activity and immunomodulatory effects through inhibition of pro-inflammatory mediators induced by whole body-gamma irradiation or cisplatin administration at two time interval early and late stage of radiation exposure (after 2 h and one week).Therefore, further studies are required to elucidate the molecular signaling pathway concerning zingerone.

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“…In the present study, distilled water was used to dissolve the ZO and VCM. The doses of VCM and ZO were determined based on previous studies, respectively …”

Section: Methodsmentioning

confidence: 99%

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

Çağlayan

Taslimi

Demir

et al. 2019

J Biochem & Molecular Tox

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In this study, it was demonstrated the ameliorative effect of zingerone (ZO) (25 and 50 mg/kg body weight) against vancomycin (VCM) (200 mg/kg body weight) administered to rats on some metabolic enzymes’ activities in the lung, liver, kidney, and testis tissues of rats. Forty‐two rats were divided into six groups as follows: control, ZO‐25, ZO‐50, VCM, VCM + ZO‐25, and VCM + ZO‐50. α‐Glycosidase, butyrylcholinesterase, aldose reductase, acetylcholinesterase, paraoxonase‐1, and carbonic anhydrase enzyme activities were significantly (P < .05) decreased in VCM group when compared with the control group. ZO, supplied with VCM, significantly activated some of these enzyme in all tissues. The results of this study showed that ZO regulates abnormal increases and decreases in VCM‐induced metabolic enzyme activities in all tissues.

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Zingerone protects against cisplatin-induced oxidative damage in the jejunum of Wistar rats

Cited by 14 publications

References 48 publications

Zingerone Targets Status Epilepticus by Blocking Hippocampal Neurodegeneration via Regulation of Redox Imbalance, Inflammation and Apoptosis

Zingerone Targets Status Epilepticus by Blocking Hippocampal Neurodegeneration via Regulation of Redox Imbalance, Inflammation and Apoptosis

Zingerone Alleviate Toxicity Induced by Cisplatin or Gamma Radiation in Rats by Modulating Pro-Inflammatory Mediators

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

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