Zinc With Oral Rehydration Therapy Reduces Stool Output and Duration of Diarrhea in Hospitalized Children: A Randomized Controlled Trial

Bhatnagar, Shinjini; Bahl, Rajiv; Sharma, Punit; Kumar, Geeta Trilok; Saxena, Shailendra K.; Bhan, Maharaj Kishan

doi:10.1097/00005176-200401000-00010

Cited by 117 publications

(93 citation statements)

References 21 publications

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“…Study characteristics are shown in Table 1 (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Only three studies had a population of fewer than 100 patients, and all studies were conducted in countries considered to be "emerging and developing economies" (48).…”

Section: Resultsmentioning

confidence: 99%

Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis

Galvão

Silva²,

Pontes³

et al. 2013

Rev Panam Salud Publica

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Galvao TF, Thees MFRS, Pontes RF, Silva MT, Pereira MG. Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis. Rev Panam Salud Publica. 2013;33(5):370-7. Suggested citationZinc supplementation for treating diarrhea in children: a systematic review and meta-analysis Results. Eighteen of 1 041 studies retrieved were included in the review (n = 7 314 children). Zinc was beneficial for reducing the duration of diarrhea in hours (mean difference [MD] = -20.12, 95% confidence interval [CI] = -29.15 to -11.09, I² = 91%). The effect was greater in malnourished children

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Section: Resultsmentioning

confidence: 99%

Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis

Galvão

Silva²,

Pontes³

et al. 2013

Rev Panam Salud Publica

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“…It has also been shown that zinc, in conjunction with ORS, is effective in reducing acute diarrhea by 15%-25%; however, its mechanism of action is uncertain (152,153). Oral zinc can correct a common micronutrient deficiency in children with diarrhea (154).…”

Section: Scientific Challenges That Remainmentioning

confidence: 99%

Enteric infections, diarrhea, and their impact on function and development

Petri¹,

Miller²,

Binder³

et al. 2008

J. Clin. Invest.

389

293

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Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration caused by infection with an enteric pathogen, but it has not changed the morbidity caused by such infections. This Review focuses on the interactions between enteric pathogens and human genetic determinants that alter intestinal function and inflammation and profoundly impair human health and development. We also discuss specific implications for novel approaches to interventions that are now opened by our rapidly growing molecular understanding.

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“…The effect of probiotics in management of acute diarrhea have been postulated and understood to be because of mechanism like immonological tolerance, producing bacterocins to act as local antibiotics, inhibiting pathogen growth by luminal pH, improving mucosal integrity by stimulating mucin production and by decreasing potent proinflammatory cytokines and enhancing the production of antiinflammatory cytokines. [2][3][4] In a published summary of 73 studies of children who sought care for diarrhea in 33 countries Rotavirus was the most frequently identified. 5,6 Optimal management of diarrhea patients including choice of therapy differs in invasive and noninvasive diarrhea.…”

Section: Discussionmentioning

confidence: 99%

“…Management of acute non bloody diarrhea includes fluids & supportive care in form of Zinc. 2,4 The management in the form of giving probiotics has long been advocated. Probiotics are by definition of WHO and FAO of United Nations are living microorganism which when administered in adequate amount confer a health benefit to the host.…”

Section: Introductionmentioning

confidence: 99%

To compare the efficacy of two probiotics in acute non bloody diarrhea

Kumar¹,

Ahmed

Vohra

et al. 2016

Int J Contemp Pediatr

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Background: According to WHO watery diarrhea is defined as passage of 3 or more loose stools without blood during preceding 24 hrs. End point of diarrhea was defined as passage of 3 stools of formed consistency. The objective of this study was tocompare the efficacy of two groups of commercially available probiotics in treating children hospitalized with acute non-bloody diarrhea on the basis of duration of stay in hospital, frequency of stool per day and duration of requirement for intravenous fluid. And to compare the results of probiotics in Rotavirus antigen positive children.Methods: A prospective interventional study was conducted in Holy Family Hospital, New Delhi in children aged between 6 months - 5 years hospitalized with acute non bloody diarrhea with 30 children in each group.Results: Total 123 children (6 months - 5 years) admitted in hospital with acute diarrhea, out of which 6 turned out to be bloody, 5 could not be followed up and 3 went LAMA. Finally 109 children with 68 males (62%) with male:female ratio of 1.65. Total 109 children (68 males) were included - Group A (33), 48 in Group B (48) and 28 in Group C (28). In a lateral study, Group A (11), Group B (23) and Group C (10) were Rotavirus positive. 49 children (45%) admitted with stool frequency of 5-10 times per day. Majority of children presented with symptoms like vomiting (68%), fever (55%), decrease oral intake (45%), decrease urine output (25%). Majority of patients 92 children (84%) were between 6 months to 2 years. 44 children (40%) were Rotavirus antigen positive.Conclusions: There is no statistical significant advantage of adding probiotics for treating acute non bloody diarrhea including Rotaviral.

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Zinc With Oral Rehydration Therapy Reduces Stool Output and Duration of Diarrhea in Hospitalized Children: A Randomized Controlled Trial

Abstract: This study demonstrates a beneficial effect of zinc administered during acute diarrhea on stool output, diarrheal duration, and proportion of episodes lasting more than 7 days. The effects are large enough to merit routine use of zinc during acute diarrhea in developing countries.

Cited by 117 publications

References 21 publications

Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis

Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis

Enteric infections, diarrhea, and their impact on function and development

To compare the efficacy of two probiotics in acute non bloody diarrhea

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