Zinc uptake and HMA4 activity are required for micro- and macroelement balance in tobacco (Nicotiana tabacum)

Liedschulte, Verena; Battey, James N. D.; Laparra, Hélène; Kleinhans, Samuel; Bovet, Lucien; Goepfert, Simon

doi:10.1016/j.phytochem.2021.112911

Cited by 5 publications

(4 citation statements)

References 81 publications

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“…For instance, NO 3 – -based fertilizers have been shown to enhance Cd concentration in Arabidopsis , rice, potatoes, and rapeseed, while Fe supply has been reported to reduce Cd concentration in Arabidopsis . Our findings also revealed enantiomeric differences in the concentrations of nutrients such as N and Fe in Arabidopsis , , echoing Chen et al who reported enantioselective effects on both micronutrients (Mn, Cu, and Fe) and macronutrients (P, K, Ca, and Mg) in Arabidopsis shoots following IM application. Interestingly, HMA4 has been implicated in regulating both micro- and macronutrients in plant shoots .…”

Section: Discussionsupporting

confidence: 85%

R-Napropamide Potentially Regulates Cadmium Accumulation in Arabidopsis Shoots through Transport Channel Modulation

Xie,

Zhu,

Zhao

et al. 2024

J. Agric. Food Chem.

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Heavy metal contamination in soils poses a significant environmental threat to human health. This study examines the effects of the chiral herbicide napropamide (NAP) on Arabidopsis thaliana, focusing on growth metrics and cadmium (Cd) accumulation. R-NAP does not adversely affect plant growth compared to the control, whereas S-NAP significantly reduces root length and fresh weight. Notably, R-NAP markedly increases Cd accumulation in the shoots, exceeding levels observed in the control and S-NAP. This increase coincides with reduced photosynthetic efficiency. Noninvasive electrode techniques reveal a higher net Cd absorption flux in the root mature zone under R-NAP than S-NAP, although similar to the control. Transcriptomic analysis highlights significant stereoisomer differences in Cd transporters, predominantly under R-NAP treatment. SEM and molecular docking simulations support that R-NAP primarily upregulates transporters such as HMA4. The results suggest careful management of herbicides like R-NAP in contaminated fields to avoid excessive heavy metal buildup in crops.

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Section: Discussionsupporting

confidence: 85%

R-Napropamide Potentially Regulates Cadmium Accumulation in Arabidopsis Shoots through Transport Channel Modulation

Xie,

Zhu,

Zhao

et al. 2024

J. Agric. Food Chem.

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“…HMA4 -impaired lines had altered mineral-dependent responses in both leaves and roots, which also caused changes in organ appearance (e.g., necroses on leaves). These results point to HMA4 involvement not only in the regulation of Cd and Zn transport, but indirectly also in the homeostasis of other mineral nutrients in the shoot (Liedschulte et al 2021 ) .…”

Section: Tobacco In Phytoremediationmentioning

confidence: 85%

“…In other studies (Liedschulte et al 2017(Liedschulte et al , 2021) silencing HMA4.1 and/or HMA4.2 with RNAi technology caused a significant decrease in Cd accumulation in the shoots and up to 90% reduction of the root-to-shoot translocation rate (by silencing both genes). Consequently, the cadmium content in the leaves of transgenic plants was lowered to less than 10%.…”

Section: Overexpression Of Genes Encoding Metal Chelatorsmentioning

confidence: 89%

“…This pointed to another important function of HMA4, namely contribution to the regulation of Zn homeostasis and the balance between the micro- and macroelements in a plant body. Genes with altered expression accompanying the observed ionomic changes were also identified in tobacco (Liedschulte et al 2021 ), providing excellent candidates for further investigation of how the complex homeostasis network works to keep the nutrient balance at Zn deficiency (here generated by blocking Zn transfer to the shoots).…”

Section: Regulation Of Zn and CD Homeostasis In Tobaccomentioning

confidence: 99%

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Tobacco as an efficient metal accumulator

Kozak

Antosiewicz

2022

Biometals

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Tobacco (Nicotiana tabacum L.) is an important industrial crop plant. However, it efficiently accumulates metals, primarily cadmium (Cd) and also zinc (Zn), in its leaves. Therefore, it could be a source of cadmium intake by smokers. On the other hand, as a high leaf metal accumulator, it is widely used for phytoremediation of metal-contaminated soil. Both issues provide an important rationale for investigating the processes regulating metal homeostasis in tobacco. This work summarizes the results of research to date on the understanding of the molecular mechanisms determining the effective uptake of Zn and Cd, their translocation into shoots and accumulation in leaves. It also discusses the current state of research to improve the phytoremediation properties of tobacco through genetic modification and to limit leaf Cd content for the tobacco industry. Graphical Abstract

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The defensin protein NtCAL1 functions as a positive factor in plant cadmium accumulation and resistance in tobacco

Jin,

Wang,

Liu

et al. 2024

Environmental and Experimental Botany

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Zinc uptake and HMA4 activity are required for micro- and macroelement balance in tobacco (Nicotiana tabacum)

Cited by 5 publications

References 81 publications

R-Napropamide Potentially Regulates Cadmium Accumulation in Arabidopsis Shoots through Transport Channel Modulation

R-Napropamide Potentially Regulates Cadmium Accumulation in Arabidopsis Shoots through Transport Channel Modulation

Tobacco as an efficient metal accumulator

The defensin protein NtCAL1 functions as a positive factor in plant cadmium accumulation and resistance in tobacco

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