Zinc transporters maintain longevity by influencing insulin/IGF‐1 activity in Caenorhabditis elegans

Abstract

Adequate dietary intake of essential metals such as zinc is important for maintaining homeostasis. Abnormal zinc intake in Caenorhabditis elegans has been shown to increase or decrease normal lifespan by influencing the insulin/ IGF-1 pathway. Distribution of zinc is achieved by a family of highly conserved zinc transport proteins (ZIPT in C. elegans). This study investigated the role of the zipt family of genes and showed that depletion of individual zipt genes results in a decreased lifespan. Moreover, zipt-16 and zipt-17 mutants synthetically interact with the insulin/IGF cofactors daf-16 and skn-1, and cause abnormal localisation of DAF-16. This study suggests that the zipt family of genes are required for maintaining normal lifespan through influencing the insulin/IGF-1 pathway.

Transcriptome Responses to Different Salinity Conditions in Litoditis marina, Revealed by Long-Read Sequencing

“…In addition, four (sic-2, acr-10, nca-2, and EVM0006162) out of five genes enriched in "ion transmembrane transporter activity" in 60‰ vs. 30‰ also had elongated 3 ′ UTRs despite the other one gene, zipt-16, having a shortened 3 ′ UTR. As expected, zipt-16 was also a significantly upregulated gene in 60‰ vs. 30‰ salinity (Supplementary Table S1), and has been reported to have interactions with daf-16 and skn-1 [59]. The two transcripts of zipt-16 (EVM0008784.1 and EVM0008784.2) were also significantly upregulated in 60‰ vs. 30‰ salinity (Supplementary Table S22).…”

N,N’ bis-(2-mercaptoethyl) isophthalamide induces developmental delay in Caenorhabditis elegans by promoting DAF-16 nuclear localization

“…Furthermore, NBMI has the potential to chelate cellular metal ions with high affinity for free sulfhydryl groups such as Zn 2+ , which play important roles in the development of the animal [ [31] , [32] , [33] ]. Studies have shown that reducing Zn 2+ levels promotes nuclear localization of DAF-16 [ 32 , 34 ]. The interactive effects of NBMI and Zn 2+ in C. elegans deserve further investigations.…”

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

“…On the contrary, zinc supplementation was shown to decrease markers of oxidative stress and the production of pro-inflammatory cytokines in elderly patients. However, surplus zinc supplementation induces senescence of several cell types and reduces lifespan in Caenorhabditis elegans [91,92]. Further in this section, we focus on recent publications investigating the role of zinc in ageing-related functional and structural changes in the cardiovascular system.…”

“…of pro-inflammatory cytokines in elderly patients. However, surplus zinc sup tion induces senescence of several cell types and reduces lifespan in Caenorhab [91,92]. Further in this section, we focus on recent publications investigating zinc in ageing-related functional and structural changes in the cardiovascular It is known that some zinc transporters are upregulated by pro-inflammato such as IL-6 (interleukin 6), in an age-dependent manner.…”