ZINC TRANSPORTER5 and ZINC TRANSPORTER9 Function Synergistically in Zinc/Cadmium Uptake

Tan, Liwen; Qu, Mengmeng; Zhu, Yan; Peng, Can; Wang, Jiurong; Gao, Dongying; Chen, Caiyan

doi:10.1104/pp.19.01569

Cited by 139 publications

(90 citation statements)

References 61 publications

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“…The functional classification of DEGs in the current investigation revealed many of the GO terms associated with ion uptake and homeostasis viz ., cation binding, metal ion binding, oxidoreductase activity etc. The deficiency of Fe and Zn alters the expression of genes associated with Fe and Zn homeostasis to regulate the plant physiological and metabolic requirement of Fe and Zn ions [ 2 , 3 , 23 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the transcripts of ZIP5 ( GRMZM2G064382 ) were enhanced under Zn deficiency in the roots (–Zn, –Fe–Zn), whereas anti-directional regulation was observed in the shoot. Several authors reported a role of ZIP transporters in the homeostasis of divalent ions viz ., Fe, Zn, Mg [ 17 , 25 , 26 , 27 , 95 ]. In maize, Li et al [ 96 ] showed that the overexpression of ZmZIP5 enhances the Zn and Fe accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…Various transporters and chelation agents viz ., oligopeptide transporters (OPT) and yellow stripe like (YSL) [ 22 , 23 ], ZIP [ 24 , 25 , 26 , 27 ], ferric reductase defective protein (FRD) transporters [ 28 ], DMA [ 29 ], nicotianamine (NA) [ 22 , 30 ], and citrate [ 31 ] have been reported to be involved in the mobilization of Fe and Zn ions. Furthermore, genome-wide transcriptome assays have been employed to understand the expression pattern of genes and pathways associated with Fe and Zn deficiencies in rice [ 32 ], Arabidopsis [ 33 ], maize [ 34 ], and several other crops [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Transcriptome Analysis of Iron and Zinc Deficiency in Maize (Zea mays L.)

Mallikarjuna

Thirunavukkarasu

Sharma

et al. 2020

Plants

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Globally, one-third of the population is affected by iron (Fe) and zinc (Zn) deficiency, which is severe in developing and underdeveloped countries where cereal-based diets predominate. The genetic biofortification approach is the most sustainable and one of the cost-effective ways to address Fe and Zn malnutrition. Maize is a major source of nutrition in sub-Saharan Africa, South Asia and Latin America. Understanding systems’ biology and the identification of genes involved in Fe and Zn homeostasis facilitate the development of Fe- and Zn-enriched maize. We conducted a genome-wide transcriptome assay in maize inbred SKV616, under –Zn, –Fe and –Fe–Zn stresses. The results revealed the differential expression of several genes related to the mugineic acid pathway, metal transporters, photosynthesis, phytohormone and carbohydrate metabolism. We report here Fe and Zn deficiency-mediated changes in the transcriptome, root length, stomatal conductance, transpiration rate and reduced rate of photosynthesis. Furthermore, the presence of multiple regulatory elements and/or the co-factor nature of Fe and Zn in enzymes indicate their association with the differential expression and opposite regulation of several key gene(s). The differentially expressed candidate genes in the present investigation would help in breeding for Fe and Zn efficient and kernel Fe- and Zn-rich maize cultivars through gene editing, transgenics and molecular breeding.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Transcriptome Analysis of Iron and Zinc Deficiency in Maize (Zea mays L.)

Mallikarjuna

Thirunavukkarasu

Sharma

et al. 2020

Plants

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“…Plant roots also secrete certain organic compounds, such as chelates, that complex with Cd ions to form ligands, allowing its entry into the root epidermis [156]. Moreover, Cd is also taken up by non-selective cation channels, Zn/Fe-regulated transporters [157], and MTPI [158]. Additionally, certain protein transports, such as NRAMPs [159], P-type ATPase (AtHMA4 and AtHMA9) [160,161], ABC transporters (OsPDR9 and AtPDR8 [131,162], and the CAX family (AtCAX2 and AtCAX5) [163,164], impart a critical role in Cd transport across the root plasma membrane.…”

Section: Mechanism Of CD Crossing the Plasma Membrane Of Rootmentioning

confidence: 99%

Phytoremediation of Cadmium: Physiological, Biochemical, and Molecular Mechanisms

Raza

Habib

Najafi-Kakavand

et al. 2020

Biology

158

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Cadmium (Cd) is one of the most toxic metals in the environment, and has noxious effects on plant growth and production. Cd-accumulating plants showed reduced growth and productivity. Therefore, remediation of this non-essential and toxic pollutant is a prerequisite. Plant-based phytoremediation methodology is considered as one a secure, environmentally friendly, and cost-effective approach for toxic metal remediation. Phytoremediating plants transport and accumulate Cd inside their roots, shoots, leaves, and vacuoles. Phytoremediation of Cd-contaminated sites through hyperaccumulator plants proves a ground-breaking and profitable choice to combat the contaminants. Moreover, the efficiency of Cd phytoremediation and Cd bioavailability can be improved by using plant growth-promoting bacteria (PGPB). Emerging modern molecular technologies have augmented our insight into the metabolic processes involved in Cd tolerance in regular cultivated crops and hyperaccumulator plants. Plants’ development via genetic engineering tools, like enhanced metal uptake, metal transport, Cd accumulation, and the overall Cd tolerance, unlocks new directions for phytoremediation. In this review, we outline the physiological, biochemical, and molecular mechanisms involved in Cd phytoremediation. Further, a focus on the potential of omics and genetic engineering strategies has been documented for the efficient remediation of a Cd-contaminated environment.

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“…Primary Zn uptake are from the soil is likely 63 performed by genes of the ZIP (Zinc-regulated/Iron-regulated transporter Protein) family 64 (Assuncao et al, 2010;Milner et al, 2013;Sinclair et al, 2018). In rice, OsZIP9 was as 65 recently described as responsible for Zn acquisition from the rhizosphere (Huang et al, 66 2020;Tan et al, 2020;Yang et al, 2020). The ZIP transporters were the first Iron (Fe) and 67…”

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confidence: 99%

Arabidopsis thaliana zinc accumulation in leaf trichomes is correlated with zinc concentration in leaves

Ricachenevsky

Punshon

Salt

et al. 2020

Preprint

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Zinc (Zn) is a key micronutrient. In humans, Zn deficiency is a common nutritional disorder, and most people acquire dietary Zn from eating plants. In plants, Zn deficiency can decrease plant growth and yield. Understanding Zn homeostasis in plants can improve agriculture and human health. While root Zn transporters in plat model species have been characterized in detail, comparatively little is known about shoot processes controlling Zn concentrations and spatial distribution. Previous work showed that Zn hyperaccumulator species such as Arabidopsis halleri accumulate Zn and other metals in leaf trichomes. The model species Arabidopsis thaliana is a non-accumulating plant, and to date there is no systematic study regarding Zn accumulation in A. thaliana trichomes. Here, we used Synchrotron X-Ray Fluorescence mapping to show that Zn accumulates at the base of trichomes of A. thaliana, as had seen previously for hyperaccumulators. Using transgenic and natural accessions of A. thaliana that vary in bulk leaf Zn concentration, we demonstrated that higher leaf Zn increases total Zn found at the base of trichome cells. Furthermore, our data suggests that Zn accumulates in the trichome apoplast, likely associated with the cell wall. Our data indicates that Zn accumulation in trichomes is a function of the Zn status of the plant, and provides the basis for future studies on a genetically tractable plant species aiming at understanding the molecular steps involved in Zn spatial distribution in leaves.

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ZINC TRANSPORTER5 and ZINC TRANSPORTER9 Function Synergistically in Zinc/Cadmium Uptake

Cited by 139 publications

References 61 publications

Comparative Transcriptome Analysis of Iron and Zinc Deficiency in Maize (Zea mays L.)

Comparative Transcriptome Analysis of Iron and Zinc Deficiency in Maize (Zea mays L.)

Phytoremediation of Cadmium: Physiological, Biochemical, and Molecular Mechanisms

Arabidopsis thaliana zinc accumulation in leaf trichomes is correlated with zinc concentration in leaves

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