Zinc Transporter-8 Gene (SLC30A8) Is Associated with Type 2 Diabetes in Chinese

Xiang, Jie; Li, Xiaoying; Xu, Min; Hong, Jing; Huang, Yun; Tan, Jiao-Rong; Lu, Xi; Dai, Meng; Yu, Bing; Ning, Guang

doi:10.1210/jc.2008-0161

Cited by 68 publications

(50 citation statements)

References 24 publications

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“…The goal of this study was to investigate whether a nonsynonymous SNP, discovered by GWAS, and related to the development of T2D (1)(2)(3)(4)(5)(6)(7)(8), was linked with parameters of skeletal muscle size, strength, or response to a resistance exercise intervention. We discovered that a copy of the risk allele was associated with skeletal muscle strength loss, skeletal muscle soreness, and CK and Mb levels after a short bout of resistance exercise and with lower pre-exercise skeletal muscle size and strength in males.…”

Section: Discussionmentioning

confidence: 99%

SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

et al. 2013

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Genome-wide association studies have identified thousands of variants that are associated with numerous phenotypes. One such variant, rs13266634, a nonsynonymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with a 53% increase in the risk of developing type 2 diabetes (T2D). We hypothesized that individuals with the protective allele against T2D would show a positive response to short-term and long-term resistance exercise. Two cohorts of young adults—the Eccentric Muscle Damage (EMD; n = 156) cohort and the Functional Single Nucleotide Polymorphisms Associated with Muscle Size and Strength Study (FAMuSS; n = 874)—were tested for association of the rs13266634 variant with measures of skeletal muscle response to resistance exercise. Our results were sexually dimorphic in both cohorts. Men in the EMD study with two copies of the protective allele showed less post-exercise bout strength loss, less soreness, and lower creatine kinase values. In addition, men in the FAMuSS, homozygous for the protective allele, showed higher pre-exercise strength and larger arm skeletal muscle volume, but did not show a significant difference in skeletal muscle hypertrophy or strength with resistance training.

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Section: Discussionmentioning

confidence: 99%

SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

et al. 2013

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“…The study protocol was approved by the Institutional Review Board of the Rui-Jin Hospital and informed consent was obtained from each participant. The study population, design and protocols of this cohort study have been described previously [18,19]. Briefly, we first invited all registered permanent residents aged 40 years or older by poster advertisement and by mail to participate in a screening examination, during which we collected information on lifestyle, medical history and the use of medications using a questionnaire, and performed anthropometrical measurements and fasting capillary glucose tests.…”

Section: Methodsmentioning

confidence: 99%

Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population

Wang

et al. 2009

Diabetologia

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“…We performed a two-step blood glucose survey in 2004-2005 in a population selected from an urban community of Shanghai, which has been reported previously [23][24][25]. In brief, we first invited all registered permanent residents aged 40-80 years in Youyi community to participate in a screening examination, which included a fasting capillary blood glucose test.…”

Section: Study Subjectsmentioning

confidence: 99%

Relationships between C-reactive protein, white blood cell count, and insulin resistance in a Chinese population

Zhao

et al. 2010

Endocr

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This study is to clarify whether C-reactive protein (CRP) and white blood cell (WBC) count influence insulin homeostasis to the same degree. Serum CRP and peripheral WBC were measured in 739 subjects with normal glucose regulation, 512 with impaired glucose regulation, and 502 newly diagnosed diabetic patients. Levels of insulin resistance (IR) were assessed using the index of homeostasis model (HOMA-IR). Serum CRP and WBC were significantly correlated with HOMA-IR and risk factors of IR. Relative risks of IR for each 1-SD increase of Ln (CRP) and Ln (WBC) were 1.28 (1.10-1.47) and 1.15 (1.01-1.31), respectively after adjustment for age, sex, obesity measurements, and other traditional risk factors. Additional adjustment for WBC slightly attenuated the association between CRP and IR [1.25 (1.08-1.45); P = 0.003] whereas adjustment for CRP substantially attenuated the association of WBC with IR toward null (P = 0.134). Moreover, individuals with both high levels of CRP and WBC were at higher risks of IR than those with high CRP or WBC alone. Both CRP and WBC were significantly associated with risks of IR. CRP might be a more effective biomarker in terms of the association with IR.

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Zinc Transporter-8 Gene (SLC30A8) Is Associated with Type 2 Diabetes in Chinese

Abstract: Our results provide evidence that SLC30A8 is a susceptible locus for type 2 diabetes in Chinese population, and its variant can influence insulin secretion.

Cited by 68 publications

References 24 publications

SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population

Relationships between C-reactive protein, white blood cell count, and insulin resistance in a Chinese population

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