Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats

Ferreira, Elaine Cristina S.; Bortolin, Raul Hernandes; Freire-Neto, Francisco Paulo; Souza, Karla Simone Costa de; Bezerra, João Felipe; Ururahy, Marcela Abbott Galvão; Ramos, Ana Maria de Oliveira; Himelfarb, Silvia Tchernin; Abreu, Bento João; Didone, Thiago Vinicius Nadaleto; Pedrosa, Lúcia Fátima Campos; Medeiros, Aldo Cunha; Doi, Sonia Q.; Brandão-Neto, José; Hirata, Rosário Dominguez Crespo; Rezende, Luciana Augusto de; Almeida, M. Gabriela; Hirata, Mario H.; Rezende, Adriana Augusto de

doi:10.1016/j.nutres.2017.03.004

Cited by 22 publications

(17 citation statements)

References 42 publications

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“…According to Zhu et al [70], Zn biomaterial can support hMSC adhesion and proliferation and zinc ions can lead to enhanced regulation of genes, cell survival/growth and differentiation, extracellular matrix (ECM) mineralization, and osteogenesis. The stimulation of osteogenesis by ionic zinc has been supported by numerous studies [71][72][73][74][75][76][77][78][79]. In the case of human vascular cells, Zn 2+ at low concentrations can enhance cell viability, proliferation, adhesion, spreading, migration, and F-actin and vinculin expression, while decreasing cell adhesion strength.…”

Section: In Vitro Examinationmentioning

confidence: 90%

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

Levy

Goldman

Aghion

2017

Metals

214

109

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Abstract:In the last decade, iron and magnesium, both pure and alloyed, have been extensively studied as potential biodegradable metals for medical applications. However, broad experience with these material systems has uncovered critical limitations in terms of their suitability for clinical applications. Recently, zinc and zinc-based alloys have been proposed as new additions to the list of degradable metals and as promising alternatives to magnesium and iron. The main byproduct of zinc metal corrosion, Zn 2+ , is highly regulated within physiological systems and plays a critical role in numerous fundamental cellular processes. Zn 2+ released from an implant may suppress harmful smooth muscle cells and restenosis in arteries, while stimulating beneficial osteogenesis in bone. An important limitation of pure zinc as a potential biodegradable structural support, however, lies in its low strength (σ UTS~3 0 MPa) and plasticity (ε < 0.25%) that are insufficient for most medical device applications. Developing high strength and ductility zinc with sufficient hardness, while retaining its biocompatibility, is one of the main goals of metallurgical engineering. This paper will review and compare the biocompatibility, corrosion behavior and mechanical properties of pure zinc, as well as currently researched zinc alloys.

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Section: In Vitro Examinationmentioning

confidence: 90%

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

Levy

Goldman

Aghion

2017

Metals

214

109

View full text Add to dashboard Cite

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“…Zn has been considered as an important element in bone metabolism because of its stimulatory effect on the growth and mineralization of bone and an inhibitory effect on the bone resorption (Ferreira et al, 2017;Hadley et al, 2010;Liu et al, 2017;Sun et al, 2011;Yamaguchi & Weitzmann, 2011). This bioelement can increase bone mass and therefore may play an important role in the prevention of bone loss and osteoporosis (Sun et al, 2011;Yamaguchi, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Zn plays an important role in the proper bone growth, development and maintenance of healthy bones in human and animals (Boughammoura et al, 2017;Ferreira et al, 2017;Hadley, Newman, & Hunt, 2010;Liu, Li, Jia, & Li, 2017;Sun, Wang, Zi, Jing, & Weng, 2011;Yamaguchi, 2010). It promotes bone formation by stimulating the proliferation and differentiation of osteoblasts, and improves osteoblastic bone mineralization by activating alkaline phosphatase and stimulating collagen synthesis (Hadley et al, 2010;Liang et al, 2012;Sun et al, 2011;Yamaguchi & Weitzmann, 2011).…”

Section: Introductionmentioning

confidence: 99%

Beneficial impact of zinc supplementation on the collagen in the bone tissue of cadmium‐exposed rats

Andrulewicz-Botulińska

Brzóska

et al. 2018

J of Applied Toxicology

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Cadmium (Cd) is a toxic metal that damages bone tissue by affecting its mineral and organic components. The organic matrix is mainly (90%) composed of collagen, which determines the biomechanical strength of bone. The aim of this study was to evaluate the effect of zinc (Zn) supplementation (30 or 60 mg l ) under moderate and relatively high exposure to Cd (5 and 50 mg l ) on collagen in the rat tibia proximal epiphysis and diaphysis (regions abundant in trabecular and cortical bone, respectively). Significant decrease in collagen type I biosynthesis was found in both regions of the tibia in Cd-treated rats, whereas the supplementation with Zn provided significant protection against this effect. Western blot confirmed the presence of the major type I collagen in the tibia epiphysis and diaphysis, but collagen type II was revealed only in the epiphysis. Acetic acid- and pepsin-soluble collagen concentration in the tibia epiphysis and diaphysis was significantly increased due to the exposure to Cd, whereas the supplementation with Zn protected, partially or totally, from these effects, depending on the used concentration. The supplementation with Zn also provided protection from unfavorable Cd impact on the maturation of the bone collagen, as the ratio of cross-links to monomers was higher compared to the Cd-treated group. This report confirms our previous findings on the preventive action of Zn against harmful effects of Cd on bone, but additionally, and to the best of our knowledge for the first time, explains the possible mechanism of the beneficial influence of this bioelement.

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“…Regulation of the release of osteoblast cytokines, including osteoprotegerin (OPG) and RANKL, is another mechanism of wear particle-induced osteolysis (7). Therefore, the OPG-RANKL-RANK axis has an important role in the pathophysiological process of aseptic loosening (8). RANK is primarily expressed on the plasma membrane of osteoclasts.…”

Section: Introductionmentioning

confidence: 99%

Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice

et al. 2018

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Aseptic loosening and menopause‑induced osteoporosis are caused by an imbalance between bone formation and osteolysis. With an aging population, the probability of simultaneous occurrence of such conditions in an elderly individual is increasing. Strontium ranelate (SR) is an anti‑osteoporosis drug that promotes bone formation and inhibits osteolysis. The present study compared the effects of SR with those of the traditional anti‑osteoporosis drug alendronate (ALN) using an ovariectomized mouse model of osteolysis. The degree of firmness of the prosthesis and the surrounding tissue was examined, a micro‑CT scan of the prosthesis and the surrounding tissue was performed, and the levels of inflammatory and osteogenic and osteoclast factors were examined. It was observed that treatment with SR and ALN improved the bond between the prosthesis and the surrounding bone tissue by reducing the degree of osteolysis, thus improving the quality of bone around the prosthesis. SR increased the secretion of osteocalcin, runt‑related transcription factor 2 and osteoprotegerin (OPG). It additionally decreased the expression of the receptor activator of nuclear factor‑κB ligand (RANKL) and consequently increased the protein ratio OPG/RANKL, whereas ALN exhibited the opposite effect. Furthermore, SR and ALN suppressed tumor necrosis factor‑α and interleukin‑1β production, with SR exerting a more marked effect. The present results demonstrate that SR and ALN may stimulate bone formation and inhibit bone resorption in the ovariectomized mouse model of wear particle‑mediated osteolysis, with SR demonstrating better effects compared with ALN.

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Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats

Cited by 22 publications

References 42 publications

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

Beneficial impact of zinc supplementation on the collagen in the bone tissue of cadmium‐exposed rats

Effects of strontium ranelate on wear particle‑induced aseptic loosening in female ovariectomized mice

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