Zinc supplementation increases growth velocity of male children and adolescents with short stature

Castillo-Durán, Carlos; García, H; Venegas, Pía; Torrealba, I; Panteón, E; Concha, N.O.; Pérez, P. Ranchal

doi:10.1111/j.1651-2227.1994.tb13154.x

Cited by 73 publications

(39 citation statements)

References 21 publications

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“…Growth can also be disturbed by deficiencies in minerals and vitamins. It was found that in the group of short stature children, zinc intake was less than 2/3 of daily demand, and zinc supplementation resulted in the acceleration of growth in boys with short stature when the cause is not determined [15]. In the presented study, the average content of zinc concentration in the blood, plasma, and urine in children with short stature was significantly lower than that in the control group.…”

Section: Discussioncontrasting

confidence: 77%

Concentration of Selected Metals in Whole Blood, Plasma, and Urine in Short Stature and Healthy Children

Klatka

Błażewicz

Partyka

et al. 2015

Biol Trace Elem Res

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The short stature in children is defined as height below the third percentile from the mean for age and gender. This problem affects about 3% of young people. More than 20,000 children in Poland have problems with short stature. There is not much information available in the literature on the study of metals in blood, plasma, and urine in children with short stature. The study was conducted on a group of 56 short stature Polish children and 35 healthy children. The content of metals was determined using high-performance ion chromatography and inductively coupled plasma mass spectrometry methods. The study revealed significant differences between the content of selected metals in body fluids between a short stature group and healthy children. There were significant differences in the Fe, Cu, and Ni concentrations between the groups with respect to the hormonal therapy. There were no significant differences between the groups with respect to the area where the children lived. The results showed no statistically significant differences between metal concentration and age, body weight, and height. The study demonstrated statistically significant differences between the content of metals in body fluids in short stature children compared with the healthy children. It seems that the difference in the concentration of certain elements may also be the result of growth hormone therapy and the interaction between various metals. Both the alterations in the content of metals and their mutual interactions may play an important role in the pathogenesis of short stature children.

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Section: Discussioncontrasting

confidence: 77%

Concentration of Selected Metals in Whole Blood, Plasma, and Urine in Short Stature and Healthy Children

Klatka

Błażewicz

Partyka

et al. 2015

Biol Trace Elem Res

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“…In several zinc supplementation studies (Walravens & Hambidge, 1976;Walravens et al, 1983;Gibson et al, 1989;Castillo-Duran et al, 1994) in which growth but not body composition was measured, positive responses in terms of height and=or weight gain have been reported in the supplemented compared to the placebo children. Less consistent positive effects on growth have been observed in vitamin A or iron supplementation studies (Angeles et al, 1993;Lawless et al, 1994;Bahl et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children

et al. 2002

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Objective: To investigate the efficacy of enhancing the content and bioavailability of micronutrients in diets of stunted rural Malawian children on their growth and body composition, morbidity, anaemia and hair zinc concentrations. Design: A quasi-experimental design with non-equivalent control group involving 410 intervention and 220 control children aged 30 -90 months. Setting and subjects: Children from two intervention and two control villages in Mangochi District, Southern Malawi participated in a 6 month dietary intervention. Anthropometry, malarial screening, haemoglobin, and hair zinc were measured at baseline and after 12 months, as well as socio-economic status at baseline, and common infections monthly postintervention. Results: Groups were comparable at baseline. Post-intervention children had greater Z-scores for lean body mass (mid-upper arm circumference 70.75 vs 71.05; arm muscle area: 0.63 vs 71.03, P < 0.001) than controls but Z-scores for weight-forheight and height-for-age were similar. After controlling for baseline variables, mean haemoglobin was higher (107 vs 102 g=l, P < 0.01), whereas the incidence of both anaemia (62 vs 80%) and common infections (based on a median overall illness score for fever, diarrhoea, upper and lower respiratory infections) were lower in intervention compared to controls, with no change in hair zinc concentrations or malaria status post-intervention. Conclusion: Improvements in the micronutrient adequacy of diets of post-intervention children were associated with a favourable increase in indices of lean body mass and reductions in the incidence of anaemia and common infections in these rural Malawian stunted children.

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“…It is possible to comment that zinc supplementation may show a positive effect on growth of adolescent children if the sample size was larger. Castillo-Durán et al (1994) have reported an increased growth velocity in males with 10 mg of zinc supplementation for 12 months to pre-adolescent and adolescent children. In a randomized control trial among Zimbabwean school children of 11-17 years of age (Friis et al, 1997), two Abbreviations: BMI, body mass index; HAZ, height-for-age z score; WAZ, weight-for-age z score.…”

Section: Effect On Anthropometrymentioning

confidence: 99%

The efficacy of micronutrient supplementation in reducing the prevalence of anaemia and deficiencies of zinc and iron among adolescents in Sri Lanka

et al. 2007

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Objective: To determine the effectiveness of combined iron and zinc over the iron or zinc-only supplementation in correcting deficiency and possible interactive effects in a group of adolescent school children. Subjects and methods: Schoolchildren (n ¼ 821) of 12-16 years of age were randomized into four groups and supplemented with iron (50 mg/day), zinc (14 mg/day), iron þ zinc or placebo capsules 5 days per week for 24 weeks. Anthropometry, and haemoglobin (Hb), serum zinc (SZn) and serum ferritin (SF) concentrations were determined before and after the intervention. Results: There were no significant effects between-groups in their weight, height and Hb concentrations with the intervention when compared with the placebo group. Iron-only and combination-supplemented groups had reached mean SF concentrations of 55.1 mg/l with no difference between them (P ¼ 0.99). The zinc-only group had a mean change of 4.3 mmol//l whereas the combine-supplemented group had a mean change of 4.0 mmol/l (P ¼ 0.82). The prevalence of anaemia was found to be 70.3% in the iron group at baseline; this was reduced to 14.5% after the supplementation. In the combinesupplemented group anaemia, prevalence was reduced from 64.8 to 19.3%. Conclusions: Zinc alone or in combination with iron has not shown a significant improvement in growth in adolescence. Severe and moderate forms of anaemia were successfully treated in children who received iron supplementation. Initial high prevalence of low SZn and iron stores was significantly improved with micronutrient supplementation.

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Zinc supplementation increases growth velocity of male children and adolescents with short stature

Cited by 73 publications

References 21 publications

Concentration of Selected Metals in Whole Blood, Plasma, and Urine in Short Stature and Healthy Children

Concentration of Selected Metals in Whole Blood, Plasma, and Urine in Short Stature and Healthy Children

Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children

The efficacy of micronutrient supplementation in reducing the prevalence of anaemia and deficiencies of zinc and iron among adolescents in Sri Lanka

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