Zinc Supplementation in Severe Acute Lower Respiratory Tract Infection in Children: A Triple-Blind Randomized Placebo Controlled Trial

Bansal, Anuradha; Parmar, Veena R.; Basu, Srikant; Kaur, Jasbinder; Jain, Suksham; Saha, Abhijeet; Chawla, Deepak

doi:10.1007/s12098-010-0244-5

Cited by 30 publications

(35 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the main findings of the current study, results from other clinical trials did not show a significant benefit of zinc supplementation in children with severe pneumonia [9,[23][24][25].…”

Section: Discussioncontrasting

confidence: 99%

“…A recent study by Bansal et al in Chandigarh, India, that studied 120 children aged 2-24 months who randomly received zinc (20 mg/d) or placebo, did not find any statistical difference in the resolution time from respiratory distress, tachypnea, hypoxia, or the duration of hospital stay between the two groups [24]. However, in contrast to this previous study, the authors did not include malnourished children or patients who suffered from wheezing or bronchiolitis.…”

Section: Discussionmentioning

confidence: 71%

See 1 more Smart Citation

The Efficacy of Zinc Supplementation on Outcome of Children with Severe Pneumonia. A Randomized Double-blind Placebo-controlled Clinical Trial

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 71%

The Efficacy of Zinc Supplementation on Outcome of Children with Severe Pneumonia. A Randomized Double-blind Placebo-controlled Clinical Trial

et al. 2011

View full text Add to dashboard Cite

show abstract

“…A total of thirteen studies remained after screening titles/abstracts. Among the thirteen studies, four were excluded, of which one (23) was an advanced abstract of an included study, two (24,25) focused on children with severe acute lower respiratory tract infection (LRTI) but not severe pneumonia and one (26) used the same data from the included trial. Finally, nine RCT (9)(10)(11)(12)(13)(14)(15)(16)(17) were included.…”

Section: Literature Searchmentioning

confidence: 99%

Zinc as an adjunct to antibiotics for the treatment of severe pneumonia in children <5 years: a meta-analysis of randomised-controlled trials

et al. 2016

View full text Add to dashboard Cite

The effect of Zn, as an adjunct to antibiotics, on the treatment of severe pneumonia in young children is still under debate; therefore, we performed a meta-analysis to evaluate the therapeutic role of Zn for severe pneumonia in children younger than 5 years. PubMed, Cochrane library and Embase databases were systematically searched from inception until October 2015 for randomised-controlled trials (RCT) that assessed the effect of Zn as an adjunct to antibiotics for severe pneumonia. Random-effects model was used for calculating the pooled estimates, and intention-to-treat principle was also applied. Nine RCT involving 2926 children were included. Overall, the pooled results showed that adjunct treatment with Zn failed to reduce the time to recovery from severe pneumonia (hazard ratios (HR) = 1·04; 95 % CI 0·90, 1·19; I 2 = 39 %; P = 0·58), hospital length of stay (HR = 1·04; 95 % CI 0·83, 1·33; I 2 = 57 %; P = 0·74), treatment failure (relative risk (RR) = 0·95; 95 % CI 0·79, 1·14; I 2 = 20 %; P = 0·58) or change of antibiotics (RR = 1·07; 95 % CI 0·79, 1·45; I 2 = 44 %; P = 0·67). In addition, continuous outcomes were consistent while meta-analysed with standard mean difference, and all outcomes remained stable in intention-to-treat analysis. No significant differences were observed in the two groups between death rate, adverse events or recovery times of severe pneumonia indicators. Our results suggested that adjunct treatment with Zn failed to benefit young children in the treatment of severe pneumonia. Considering the clinical heterogeneity, baseline characteristics of children, definition of severe pneumonia and Zn supplement way should be taken into consideration in future research. This study was registered at PRESPERO as CRD42015019798.Key words: Children: Meta-analyses: Severe pneumonia: ZincPneumonia is a leading disease and cause of death in children under 5 years in developing countries (1) . It is reported that 14·9 % of 6·3 million deaths of children <5 years old were caused by pneumonia worldwide (2) . With advances in medicine, economy and society, pneumonia with diarrhoea and measles was responsible for half of the reduction in mortality of children under 5 years from 2000 to 2013 (2) . Although great progress was achieved, only a few countries could reach the goal of Millennium Development Goal 4 to reduce under 5 child mortality by two-thirds between 1990 and 2015, and pneumonia is still the leading cause of child mortality (3) . Therefore, intensive effort should be made in the research of pneumonia.Under-nutrition has been reported to be strongly associated with impaired immune response, (4) and it has been proven to be responsible for greater severity of pneumonia, prolonged course of disease and increased mortality of pneumonia (5) .Zn, as an important micro-element, has an essential role in cellular growth and immune defence, and its deficiency is associated with significant increased susceptibility to various infection pathogens (6)(7)(8) . In a randomised-controlled trial (RCT...

show abstract

“…This yielded 4 and 7 publications respectively, of which 1 prophylaxis trial [7] and one therapy trial [8] were relevant. Two therapy trials in this Journal [5,6] do not yet appear in Pubmed. Three publications were excluded for the following reason: pneumonia not an outcome [9], respiratory outcome described not consistent with definition of pneumonia [10], trial in HIV-infected children [11].…”

Section: Methodsmentioning

confidence: 99%

“…In December 2010, a new Cochrane review with 6 RCT reported that zinc supplementation reduces incidence and prevalence of pneumonia [4]. Even more recently, a triple blinded RCT examining zinc supplementation in addition to antibiotic therapy for severe and very severe pneumonia was published in this Journal and concluded that there was no therapeutic benefit [5]. This issue of the Journal carries yet another RCT suggesting the opposite viz that zinc is beneficial in children with severe pneumonia [6].…”

mentioning

confidence: 99%

The Role of Zinc in Prevention and Treatment of Childhood Pneumonia: An Examination and Appraisal of Current Evidence

Mathew

2011

Indian J Pediatr

View full text Add to dashboard Cite

Zinc Supplementation in Severe Acute Lower Respiratory Tract Infection in Children: A Triple-Blind Randomized Placebo Controlled Trial

Abstract: Zinc supplementation did not reduce recovery time and duration of hospital stay in children with ALRTI. Larger randomized controlled trials are needed to evaluate role of zinc in ALRTI.

Cited by 30 publications

References 15 publications

The Efficacy of Zinc Supplementation on Outcome of Children with Severe Pneumonia. A Randomized Double-blind Placebo-controlled Clinical Trial

The Efficacy of Zinc Supplementation on Outcome of Children with Severe Pneumonia. A Randomized Double-blind Placebo-controlled Clinical Trial

Zinc as an adjunct to antibiotics for the treatment of severe pneumonia in children <5 years: a meta-analysis of randomised-controlled trials

The Role of Zinc in Prevention and Treatment of Childhood Pneumonia: An Examination and Appraisal of Current Evidence

Contact Info

Product

Resources

About