Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial

Abstract

BackgroundThe present study was designed to determine whether zinc supplementation would increase the effects of restricted calorie diet (RCD) on obesity.Methods and materialsA randomized, double-blind clinical trial was performed on 40 obese subjects who were randomly assigned to receive zinc supplements (30 mg/day) or placebo for a period of 15-weeks. Both groups were under a restricted calorie diet (~ 300 kcal lower than the estimated energy requirement). Anthropometric measurements, biochemical markers, appetite, and dietary intakes were determined during the study period.ResultsThe reductions of body weight, body mass index, waist circumference, and hip circumference were significantly higher in the zinc group compared to the placebo group (P = 0.032, 0.025, 0.003, and 0.0001, respectively). Lower levels of high sensitivity C-reactive protein, apelin, homeostatic model assessment of insulin resistance (HOMA-IR), and appetite score were observed in the zinc group in comparison with the placebo group (P = 0.0001, 0.001, 0.031 and 0.001 respectively).ConclusionThis study indicates that Zn supplementation with a restricted calorie diet has favorable effects in reducing anthropometric measurements, inflammatory markers, insulin resistance and appetite in individuals with obesity, and may play an effective role in the treatment of obesity.Trial registration This clinical trial was registered at clinicaltrials.gov at the U.S. National Library of Medicine (NCT02516475).

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

“…A haemorrhagic stroke is mainly caused by a rupture and pathological changes in small vessels. The authors consider zinc to be a modifiable risk factor for haemorrhagic stroke, particularly in relation to the incidence of zinc deficiency in obesity and type 2 diabetes mellitus [ 57 , 58 , 59 ].…”

“…Zinc administration in overweight patients leads to an improvement of the body–mass index (BMI) and the lipid profile, especially the triglycerides (TG) [ 57 ]. Recently, Khorsadi et al [ 58 ] report on the results of a randomised, placebo-controlled double-blind study in 40 obese patients. One group of 20 patients each received a zinc supplement (30 mg/day) or placebo for 15 weeks combined with a restricted diet of 300 kcal.…”

Association between dietary mineral nutrient intake, body mass index, and waist circumference in U.S. adults using quantile regression analysis NHANES 2007–2014

“…High-dietary phosphorus, especially from foods processed with phosphate salts may be positively correlated with obesity (Anderson, 2013). Recent studies have shown that the mineral supplements can reduce body weight and inflammation and improve lipid metabolism, such as mineral supplements of calcium (Ilich et al, 2019), magnesium (De Baaij, Hoenderop & Bindels, 2015), zinc, copper and selenium (Khorsandi et al, 2019;Lee, 2018;Roman, Jitaru & Barbante, 2014).…”

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“…These lower zinc levels in biological fluids have been associated with a higher risk of developing insulin resistance, inflammation, hypertension, and hypertriglyceridemia (141) . Another study revealed that a diet energy-restricted with 30 mg/day of zinc reduced inflammatory markers, insulin resistance, anthropometric measurements, and appetite in individuals with obesity (142) .…”