Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years

Imdad, Aamer; Rogner, Jaimie; Sherwani, Rida N; Sidhu, Jasleen; Regan, Allison; Haykal, Maya R; Tsistinas, Olivia; Smith, Abigail; Chan, Xin Hui S; Mayo‐Wilson, Evan; Bhutta, Zulfiqar Ahmed

doi:10.1002/14651858.cd009384.pub3

Cited by 8 publications

(11 citation statements)

References 303 publications

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“…245 Zinc supplementation did not change all-cause mortality and morbidity in children, but reduced the risk of all-cause diarrhea, and improved slightly growth in children between 0.5 and 12 years. 246 Similarly, zinc supplementation did not improve the outcome in HIV adults with heavy alcohol use. 247 However, in several RCT-trials in neonates with sepsis zinc in addition to antibiotics significantly reduced inflammatory markers and sometimes mortality.…”

Section: Zincmentioning

confidence: 97%

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Roth‐Walter,

Berni Canani,

O'Mahony

et al. 2023

Allergy

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Nutritional Immunity is one of the most ancient innate immune responses, during which the body can restrict nutrients availability to pathogens and restricts their uptake by the gut mucosa (mucosal block). Though this can be a beneficial strategy during infection, it also is associated with non‐communicable diseases—where the pathogen is missing; leading to increased morbidity and mortality as micronutritional uptake and distribution in the body is hindered. Here, we discuss the acute immune response in respect to nutrients, the opposing nutritional demands of regulatory and inflammatory cells and particularly focus on some nutrients linked with inflammation such as iron, vitamins A, Bs, C, and other antioxidants. We propose that while the absorption of certain micronutrients is hindered during inflammation, the dietary lymph path remains available. As such, several clinical trials investigated the role of the lymphatic system during protein absorption, following a ketogenic diet and an increased intake of antioxidants, vitamins, and minerals, in reducing inflammation and ameliorating disease.

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Section: Zincmentioning

confidence: 97%

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Roth‐Walter,

Berni Canani,

O'Mahony

et al. 2023

Allergy

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“…Zinc deficiency may arise from a combination of factors, including inadequate intake, mostly caused by poor diet, diminished absorption, or increased intestinal loss resulting from inflammatory processes (e.g., bowel diseases) [ 82 ]. Around 50% of children in low- and middle-income countries may have zinc deficiency due to limited food availability [ 33 ]. Paediatric zinc deficiency is a public health concern in many countries [ 66 ].…”

Section: Zincmentioning

confidence: 99%

“…Although the main use of zinc supplementation is for treating the malnourished paediatric population, the number of studies reporting positive outcomes as a preventive intervention in healthy children is growing [ 33 , 34 , 104 , 116 , 119 , 120 , 121 , 122 ].…”

Section: Zincmentioning

confidence: 99%

“…Based on dietary intake surveys, zinc deficiency is estimated to be prevalent in most young and adult populations in developed and developing countries, especially in Asia [ 30 ]. Paediatric zinc deficiency is prevalent in low- and middle-income countries and is considered a significant risk factor for morbidity, mortality, and stunting [ 31 , 32 , 33 ]. Preventive zinc supplementation in healthy children could reduce mortality due to common causes like diarrhoea, pneumonia, and malaria [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…Paediatric zinc deficiency is prevalent in low- and middle-income countries and is considered a significant risk factor for morbidity, mortality, and stunting [ 31 , 32 , 33 ]. Preventive zinc supplementation in healthy children could reduce mortality due to common causes like diarrhoea, pneumonia, and malaria [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Potential Complementary Effect of Zinc and Alkalihalobacillus clausii on Gut Health and Immunity: A Narrative Review

Wong-Chew,

Nguyen,

Rogacion

et al. 2024

Nutrients

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A balanced microbiota—microorganisms that live in the gut—is crucial in the early years of a child’s life, while dysbiosis—altered microbiota—has been linked to the development of various diseases. Probiotics, such as Alkalihalobacillus clausii, are commonly used to restore the balance of gut microbiota and have shown additional antimicrobial and immunomodulatory properties. Intake of micronutrients can affect the structure and function of the gut barrier and of the microbiota by having multiple effects on cellular metabolism (e.g., immunomodulation, gene expression, and support structure proteins). An inadequate zinc intake increases the risk of deficiency and associated immune dysfunctions; it is responsible for an increased risk of developing gastrointestinal diseases, respiratory infections, and stunting. Paediatric zinc deficiency is a public health concern in many countries, especially in low-income areas. Currently, zinc supplementation is used to treat childhood diarrhoea. This review examines how combining A. clausii and zinc could improve dysbiosis, gut health, and immunity. It suggests that this combination could be used to prevent and treat infectious diseases and diarrhoea in children up to adolescence.

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Is there RCT evidence to support the use of zinc supplementation in children for preventing mortality, morbidity, and growth failure?

Lai¹

2023

Cochrane Clinical Answers

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Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years

Cited by 8 publications

References 303 publications

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Potential Complementary Effect of Zinc and Alkalihalobacillus clausii on Gut Health and Immunity: A Narrative Review

Is there RCT evidence to support the use of zinc supplementation in children for preventing mortality, morbidity, and growth failure?

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