Zinc supplementation for improving glucose handling in pre-diabetes: A double blind randomized placebo controlled pilot study

Islam, Rafiqul; Attia, John; Ali, Liaquat; McEvoy, Mark; Selim, Shahjada; Sibbritt, David; Akhter, Ayesha; Akter, Shahnaz; Peel, Roseanne; Mona, Tazreen; Lona, Hafiza; Milton, Abul Hasnat

doi:10.1016/j.diabres.2016.03.010

Cited by 83 publications

(65 citation statements)

References 25 publications

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“…The results of the present study demonstrate that zinc supplementation helps reduce blood glucose (FPG and 2‐h OGTT plasma glucose) and insulin resistance (HOMA‐IR) while improving β‐cell function (HOMA‐β). Similar results have been reported in another recently concluded pilot study, also conducted in an ethnic South Asia population with prediabetes . However, the smaller sample size and lack of control for potential confounder variables for glycemic control (physical activity, diet, and anthropometric parameters) are limitations of that study .…”

Section: Discussionsupporting

confidence: 84%

“…A recent 6‐month pilot study conducted in Bangladesh demonstrated that zinc supplementation improves glucose handling in prediabetes . Even under the most rigorous study design conditions, a well‐planned single study rarely provides definitive results to change clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…15 A recent 6-month pilot study conducted in Bangladesh demonstrated that zinc supplementation improves glucose handling in prediabetes. 16 Even under the most rigorous study design conditions, a wellplanned single study rarely provides definitive results to change clinical practice. Large-scale, long-term studies, followed by pooled analysis via systematic reviews, are necessary prior to arriving at definitive conclusions, especially with regards to long-term efficacy and safety.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Zinc supplementation in prediabetes: A randomized double‐blind placebo‐controlled clinical trial

Ranasinghe

Wathurapatha

Galappatthy

et al. 2018

Journal of Diabetes

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Zinc supplementation in prediabetes: A randomized double‐blind placebo‐controlled clinical trial

Ranasinghe

Wathurapatha

Galappatthy

et al. 2018

Journal of Diabetes

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“…A recent study reported an improvement in glucose handling in subjects with pre-diabetes supplemented with zinc, and this could potentially be a safe way to prevent the progression of the pre-diabetes stage to diabetes [29]. Previous studies on dietary and supplemental zinc showed a potential protective effect on type 2 diabetes [30].…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Zinc, Magnesium and Selenium among First Trimester Pregnant Saudi Women with Pre-Diabetes and Diabetes

Hammouda¹,

Sultan²,

Mohamadin³

2017

Endocrinol Metab Syndr

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“…17 Furthermore, Zinc supplementation has also been shown to improve glucose handling in pre-diabetes. 18 Zinc deficiency is known to have numerous detrimental health effects.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of zinc in pre-diabetes: a pilot study

Ranasinghe¹,

Galappatthy²,

Katulanda³

et al. 2018

JDMDC

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Abbreviations: AUC, area under the curve; BMI, body mass index; GCP, good clinical practice; IFG, impaired fasting glucose; IGT, impaired glucose tolerance; ITI, industrial technology institute; SD, standard deviation; WHO, world health organization IntroductionZinc is an essential trace element that plays a vital role as a co-factor in enzyme action, cell membrane stabilization, gene expression and cell signaling.1 It is also important in insulin action and carbohydrate metabolism.2 Zinc is involved in the physiology of insulin at several stages; it is found in the insulin secretory granules and is known to participate in the insulin synthesis, stabilization of pro-insulin, insulin secretion, insulin sensitivity, and insulin degradation.3,4 Zinc could also play a role in the pathogenesis of diabetes. Studies have shown that diabetes is accompanied by hypozincemia and hyperzincuria. 5,6 Zinc absorption is also know to be altered in patients with diabetes. 7The altered Zinc absorption and hyperzincuria identified in patients with diabetes is an indication of either the fact that Zinc metabolism is altered as a result of diabetes or the altered Zinc metabolism plays a role in the pathogenesis of diabetes. Homeostasis of Zinc is thought to depend on absorption as well as excretion. Studies have shown that the Zinc ingested by healthy persons are eliminated in the feces (90%) and in urine (2-10%).8 Zinc is primarily absorbed from small intestine, duodenum and ileum. 9 The oral Zinc tolerance test was proved to be an acceptable method to study zinc absorption and excretion in humans.10 Absorption and/or excretion of Zinc may be altered in various pathological states, such as diabetes mellitus. Pre-diabetes is an intermediate state of hyperglycemia with glycaemic parameters above normal but below the threshold for the initiation of treatment for diabetes.11 The pre-diabetic state is characterized by either impaired glucose tolerance (IGT), impaired fasting glucose (IFG) or both. In a meta-analysis evaluating the progression of pre-diabetes to diabetes published in 2007, the annual incidence rate of diabetes was found to be 4%-6% for isolated IGT, for isolated IFG 6%-9% and for both Presently there are no studies examining the pharmacokinetic properties of Zinc in pre-diabetes. Understanding Zinc metabolism in the pre-diabetic state could help to define the role of Zinc in the pathogenesis of diabetes mellitus. Hence the present study aims to investigate the pharmacokinetic parameters of Zinc in pre-diabetes using the oral Zinc tolerance test. MethodsThe present study was conducted as a pharmacokinetic substudy of a randomized controlled trial evaluating the effects of Zinc AbstractBackground: Zinc is an essential trace element that plays a vital role as a co-factor in enzyme action. It is also important in insulin action and carbohydrate metabolism. Understanding Zinc metabolism in the pre-diabetic state could help to define the role of Zinc in the pathogenesis of diabetes mellitus. The present study aims to investi...

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Zinc supplementation for improving glucose handling in pre-diabetes: A double blind randomized placebo controlled pilot study

Cited by 83 publications

References 25 publications

Zinc supplementation in prediabetes: A randomized double‐blind placebo‐controlled clinical trial

Zinc supplementation in prediabetes: A randomized double‐blind placebo‐controlled clinical trial

Serum Levels of Zinc, Magnesium and Selenium among First Trimester Pregnant Saudi Women with Pre-Diabetes and Diabetes

Pharmacokinetics of zinc in pre-diabetes: a pilot study

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