Zinc supplementation and the effects on metabolic status in gestational diabetes: A randomized, double-blind, placebo-controlled trial

Karamali, Maryam; Heidarzadeh, Zahra; Seifati, Seyed Morteza; Samimi, Mansooreh; Tabassi, Zohreh; Hajijafari, Mohammad; Asemi, Zatollah; Esmaillzadeh, Ahmad

doi:10.1016/j.jdiacomp.2015.07.001

Cited by 50 publications

(25 citation statements)

References 31 publications

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“…This study demonstrated that zinc supplementation compared with the placebo in patients with DFU for 12 weeks had potential to decrease FPG, serum insulin, HOMA‐IR, HOMA‐B, HbA1c, and total‐/HDL‐cholesterol ratio, and to increase QUICKI and HDL‐cholesterol levels, but did not affect other lipid profiles. Our previous study shown that taking 30 mg/day zinc supplements for 6 weeks among GDM women resulted in significant decreases in FPG, serum insulin concentrations, HOMA‐IR, HOMA‐B, serum triglycerides, VLDL‐cholesterol, and a significant rise in QUICKI . In addition, supplementation with 20 mg/day elemental zinc for 8 weeks in prepubertal obese children led to significant reductions in FPG, insulin and HOMA‐IR, but did not influence lipid profiles .…”

Section: Discussionmentioning

confidence: 96%

“…Furthermore, the favorable effects of zinc supplementation on markers of insulin metabolism, circulating biomarkers of inflammation, and oxidative stress among patients without DFU were reported. We have previously found that 233 mg zinc gluconate (containing 30 mg zinc) supplementation for 6 weeks among women with gestational diabetes (GDM) had beneficial effects on insulin metabolism, lipid profiles, and biomarkers of inflammation and oxidative stress . However, no significant change in fasting glucose, insulin and lipid concentrations was observed following supplementation with 240 mg zinc as zinc gluconate per day among patients with type 2 diabetes mellitus (T2DM) with normal zinc levels for 3 months …”

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confidence: 99%

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Expression of Concern: The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Momen‐Heravi

Barahimi

Razzaghi

et al. 2017

Wound Repair Regeneration

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This study was performed to determine the effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer. The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 40-85 years old) with grade 3 diabetic foot ulcer. Participants were randomly divided into two groups (30 participants in each group) to take either 220 mg zinc sulfate supplements containing 50 mg elemental zinc or placebo daily for 12 weeks. After the 12-week intervention, compared with the placebo, zinc supplementation was associated with significant reductions in ulcer length (-1.5 ± 0.7 vs. -0.9 ± 1.2 cm, p = 0.02) and width (-1.4 ± 0.8 vs. -0.8 ± 1.0 cm, p = 0.02). In addition, changes in fasting plasma glucose (-40.5 ± 71.0 vs. -3.9 ± 48.5 mg/dl, p = 0.02), serum insulin concentration (-8.0 ± 15.4 vs. +1.1 ± 10.3 µIU/ml, p = 0.009), homeostasis model of assessment-estimated insulin resistance (-3.9 ± 7.1 vs. +0.8 ± 5.9, p = 0.007), the quantitative insulin sensitivity check index (+0.01 ± 0.03 vs. -0.002 ± 0.02, p = 0.04) and HbA1c (-0.5 ± 0.8 vs. -0.1 ± 0.5%, p = 0.01) in the supplemented group were significantly different from the changes in these indicators in the placebo group. Additionally, significant increases in serum HDL-cholesterol (+4.1 ± 4.3 vs. +1.1 ± 5.1 mg/dl, p = 0.01), plasma total antioxidant capacity (+91.7 ± 213.9 vs. -111.9 ± 188.7 mmol/L, p < 0.01) and total glutathione (+68.1 ± 140.8 vs. -35.0 ± 136.1 µmol/L, p = 0.006), and significant decreases in high sensitivity C-reactive protein (-20.4 ± 24.6 vs. -6.8 ± 21.3 µg/ml, p = 0.02) and plasma malondialdehyde concentrations (-0.6 ± 0.9 vs. -0.2 ± 0.7 µmol/L, p = 0.03) were seen following supplementation with zinc compared with the placebo. Zinc supplementation for 12 weeks among diabetic foot ulcer patients had beneficial effects on parameters of ulcer size and metabolic profiles.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Expression of Concern: The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Momen‐Heravi

Barahimi

Razzaghi

et al. 2017

Wound Repair Regeneration

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“…After reading the titles and abstracts, 54 studies were selected for further review. Finally, thirteen studies met our inclusion criteria [22][23][24][25][26][27][28][29][30][31][32][33][34]. The detailed process of the search strategy is described in Figure 1.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Twelve studies [22][23][24][25][26][27][28][29][31][32][33][34] reported methods for generating random sequences, which were mainly computerized randomization methods. Seven studies mentioned the use of allocation concealment, and three of these studies described specific methods [25,27,29]. Five studies [22,25,28,31,33] clearly illustrated the blinding of participants and personnel.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

Jin

Sha

Dong

et al. 2020

Journal of Diabetes Research

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Background. Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, and nutritional therapy is the basis of GDM treatment. However, the effects of different forms of nutritional supplementation on improving gestational diabetes are uncertain. Objective. We conducted a network meta-analysis to evaluate the effects of supplementation with different nutrients on glucose metabolism in women with GDM. Methods. We conducted a literature search using PubMed, EMBASE, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing the differences between different nutritional strategies in women with GDM. The Cochrane tool was used to assess the risk of bias. Pairwise meta-analysis and network meta-analysis were used to compare and rank the effects of nutritional strategies for the improvement of fasting plasma glucose (FPG), serum insulin, and homeostasis model assessment-insulin resistance (HOMA-IR). Results. We included thirteen RCTs with a total of 754 participants. Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR. Network analysis showed that vitamin D supplementation was superior to omega-3 (-3.64 mg/dL, 95% CI: -5.77 to -1.51), zinc (-5.71 mg/dL, 95% CI: -10.19 to -1.23), probiotics (-6.76 mg/dL, 95% CI: -10.02 to -3.50), and placebo (-12.13 mg/dL, 95% CI: -14.55 to -9.70) for improving FPG. Magnesium supplementation was more beneficial for decreasing serum insulin compared with probiotics (-5.10 μIU/mL, 95% CI: -9.32 to -0.88) and placebo (-7.80 μIU/mL; 95% CI-11.95, -3.65). Vitamin D was more effective than probiotics (-0.99, 95% CI: -1.84 to -0.14) and placebo (-1.80, 95% CI: -2.45 to -1.16) for improving HOMA-IR. Conclusion. Vitamin D supplementation significantly reduced FPG and regulated HOMA-IR. Magnesium supplementation was superior in decreasing serum insulin than supplementation with other nutrients. Nutrient supplementation seemed to have an effect on glucose homeostasis maintenance in patients with GDM and may be considered an adjunctive therapy.

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“…Both dietary zinc intake and serum levels of zinc have been inversely associated with gestational hyperglycemia, especially among women with GDM (4,5). Zinc homeostasis in the pancreatic β-cell is mainly mediated by zinc transporter 8 (ZnT8), the product of zinc transporter 8 gene SLC30A8 (6).…”

Section: Introductionmentioning

confidence: 99%

Zinc-Associated Variant in SLC30A8 Gene Interacts With Gestational Weight Gain on Postpartum Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes Mellitus

et al. 2016

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Zinc transporter 8 genetic variant SLC30A8 has been associated with postpartum risk of type 2 diabetes among women with gestational diabetes mellitus (GDM). Gestational weight gain is one of the strongest risk factors for postpartum hyperglycemia. We assessed the interaction between type 2 diabetes–associated SLC30A8 rs13266634 and gestational weight gain on 1–5 years of postpartum glycemic changes in 1,071 women with prior GDM in a longitudinal study. Compared with gestation of 26–30 weeks, postpartum levels of fasting glucose, oral glucose tolerance test 2-h glucose, and hemoglobin A1c (HbA1c) increased across rs13266634 TT, CT, and CC genotypes in women with excessive gestational weight gain, whereas opposite genetic associations were found in women with inadequate or adequate gestational weight gain. Postpartum changes in fasting glucose per additional copy of the C allele were −0.18, −0.04, and 0.12 mmol/L in women with inadequate, adequate, and excessive gestational weight gain, respectively (P for interaction = 0.002). We also found similar interactions for changes in 2-h glucose and HbA1c (P for interaction = 0.003 and 0.005, respectively). Our data indicate that gestational weight gain may modify SLC30A8 variant on long-term glycemic changes, highlighting the importance of gestational weight control in the prevention of postpartum hyperglycemia in women with GDM.

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Zinc supplementation and the effects on metabolic status in gestational diabetes: A randomized, double-blind, placebo-controlled trial

Cited by 50 publications

References 31 publications

Expression of Concern: The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Expression of Concern: The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

Zinc-Associated Variant in SLC30A8 Gene Interacts With Gestational Weight Gain on Postpartum Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes Mellitus

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