Zinc supplementation and growth of infants born small for gestational age

Castillo-Durán, Carlos; Rodríguez, Aldo; Venegas, Guillermo; Álvarez, Pablo; Icaza, Gloria

doi:10.1016/s0022-3476(95)70296-2

Cited by 103 publications

(59 citation statements)

References 24 publications

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“…These results agree with those of previous studies that support an advantage of zinc supplementation early in life. Twelve randomized controlled trials (RCTs) were conducted in subjects aged ,28 d of life (13,15,19,(31)(32)(33)(34)(35)(36)(37)(38)(39). Seven studies had a double-blind design, and most of these trials enrolled slightly preterm or small-for-gestational-age neonates (13,15,19,32,34,37,38).…”

Section: Discussionmentioning

confidence: 99%

“…None of these trials enrolled VLBW preterm neonates. A systematic review (16) on the effect of neonatal zinc supplementation on preventing morbidity and mortality evaluated 3 trials including low-birth-weight infants receiving zinc within the first month of life for $14 d (32,34,38). They concluded that the available data were too limited to evaluate the efficacy of zinc on longterm morbidity and mortality and that the 3 trials analyzed were not adequately powered to evaluate these outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

Terrin¹,

Canani²,

Passariello³

et al. 2013

The American Journal of Clinical Nutrition

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Background: Zinc plays a pivotal role in the pathogenesis of many diseases and in body growth. Preterm neonates have high zinc requirements. Objective: The objective of the study was to investigate the efficacy of zinc supplementation in reducing morbidity and mortality in preterm neonates and to promote growth. Design: This was a prospective, double-blind, randomized controlled study of very-low-birth-weight preterm neonates randomly allocated on the seventh day of life to receive (zinc group) or not receive (control group) oral zinc supplementation. Total prescribed zinc intake ranged from 9.7 to 10.7 mg/d in the zinc group and from 1.3 to 1.4 mg/d in the placebo control group. The main endpoint was the rate of neonates with $1 of the following morbidities: lateonset sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, periventricular leucomalacia, and retinopathy of prematurity. Secondary outcomes were mortality and body growth. Results: We enrolled 97 neonates in the zinc group and 96 in the control group. Morbidities were significantly lower in the zinc group (26.8% compared with 41.7%; P = 0.030). The occurrence of necrotizing enterocolitis was significantly higher in the control group (6.3% compared with 0%; P = 0.014). Mortality risk was higher in the placebo control group (RR: 2.37; 95% CI: 1.08, 5.18; P = 0.006). Daily weight gain was similar in the zinc (18.2 6 5.6 g $ kg 21 $ d 21 ) and control (17.0 6 8.7 g $ kg 21 $ d 21

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

Terrin¹,

Canani²,

Passariello³

et al. 2013

The American Journal of Clinical Nutrition

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“…This phenomenon is now considered largely the result of relating the growth rate of premature infants to the chronological age since birth rather than age since conception (Casey et al, 1990;Karniski et al, 1987). Although small-for-gestational age (SGA) infants show some growth spurts in the ®rst 3 ± 6 months of life, especially those with asymmetric growth retardation, they remain persistently shorter (Castillo-Duran et al, 1995;Tenovuo et al, 1987;Villar et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Determinants of infant growth in the slums of Dhaka: size and maturity at birth, breastfeeding and morbidity

Arifeen

Caulfield

et al. 2001

Eur J Clin Nutr

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Objective: To investigate the in¯uences of size at birth, breastfeeding and morbidity on growth during infancy in poor areas of urban Bangladesh. Design: This was a prospective observational study of a cohort of newborn infants followed until 12 months of age. Setting: Slum areas of Dhaka City in Bangladesh. Subjects: A total of 1654 newborn infants were enrolled at birth, and follow-up was completed for 1207 infants. Repeated anthropometric measurements and interviews of caretakers on infant feeding and morbidity were conducted. A mixed effects regression method was used for modeling infant growth. Results: After adjusting for other variables, mean differences in body weight by birth weight and length, smallfor-gestational age and prematurity categories remained relatively constant throughout infancy. A positive impact of exclusive breastfeeding in the ®rst 3 ± 5 months on infant growth was detectable at 12 months of age. Although the bigger babies in the sample tended to grow relatively even bigger; exclusive breastfeeding appeared to counteract this pattern. Reported diarrhoea was associated with lower body weights and lengths even after adjusting for feeding patterns.Conclusions: Size at birth has an important role in determining growth during infancy. Effective strategies for improving birth weight, poorly addressed till now in Bangladesh, are needed. The sustained effect on growth and the even more bene®cial effect in lighter infants are compelling reasons for promotion of exclusive breastfeeding in early infancy.

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“…Castillo-Duran et al 10 in their study of Zn supplementation on 68 term small for gestation age (SGA) infants (starting at 3 days of life and continuing till 6 months post natal age) also found significant effect of zinc supplementation on weight, length, and linear growth to control group .The difference was obvious even at the first follow up at 4 weeks although it was significant only for length.…”

Section: Discussionmentioning

confidence: 92%

To Study the Role of Zinc Supplementation on Growth of Low Birth Weight Infants

Sonawane

Patil

Gulati

et al. 2014

MVP Journal of Medical Science

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This was a randomized controlled trial undertaken to study the role of zinc supplementation on growth of low birth weight infants (b.wt≤2500 gm). Out of 120 LBW infants, 23 were excluded due to loss of follow up. The remaining 97 LBW eligible neonates were randomized in to 2 group (zinc & control group), zinc group were given zinc supplementation at a dose of 2 mg/kg/day for 8 weeks from enrollment. They were then followed up every 4 weeks up to 8 weeks. At each visit, detail anthropometry including e weight, length, and head circumference were recorded at each visit. The infants in the zinc group had significantly higher weight gain (p<0.000), length gain (p<0.000), linear growth velocity and head circumference at 8 weeks. We concluded that zinc supplementation at 2 mg/kg/day for 8 weeks in LBW infants improves their growth during infancy.

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Zinc supplementation and growth of infants born small for gestational age

Cited by 103 publications

References 24 publications

Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

Determinants of infant growth in the slums of Dhaka: size and maturity at birth, breastfeeding and morbidity

To Study the Role of Zinc Supplementation on Growth of Low Birth Weight Infants

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