Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial

Salari, Soheila; Khomand, Payam; Arasteh, Modabber; Yousefzamani, Bahareh; Hassanzadeh, Kambiz

doi:10.1016/j.pharep.2015.01.002

Cited by 39 publications

(30 citation statements)

References 20 publications

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“…With less glutamate in the synapse, glutamate binding at the NMDA receptor is consequently reduced (Salari et al, 2015). Furthermore, the dehydrogenase and decarboxylase enzymes that catabolize glutamate have reduced activity in the presence of zinc (Prakash et al, 2015).…”

Section: Nmda Receptor Anatomy and Physiologymentioning

confidence: 99%

“…Lastly, zinc inhibits the group I metabotropic glutamate receptors (mGluR), diminishing Ca +2 release from internal neuron stores. Ca +2 enhances the activity of the NMDA receptor, so zincs role to decrease the Ca +2 availability further reduces NMDA receptor functionality (Howland and Wang, 2008; Salari et al, 2015). …”

Section: Nmda Receptor Anatomy and Physiologymentioning

confidence: 99%

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The Emerging Role for Zinc in Depression and Psychosis

et al. 2017

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Zinc participation is essential for all physiological systems, including neural functioning, where it participates in a myriad of cellular processes. Converging clinical, molecular, and genetic discoveries illuminate key roles for zinc homeostasis in association with clinical depression and psychosis which are not yet well appreciated at the clinical interface. Intracellular deficiency may arise from low circulating zinc levels due to dietary insufficiency, or impaired absorption from aging or medical conditions, including alcoholism. A host of medications commonly administered to psychiatric patients, including anticonvulsants, oral medications for diabetes, hormones, antacids, anti-inflammatories and others also impact zinc absorption. Furthermore, inefficient genetic variants in zinc transporter molecules that transport the ion across cellular membranes impede its action even when circulating zinc concentrations is in the normal range. Well powered clinical studies have shown beneficial effects of supplemental zinc in depression and it important to pursue research using zinc as a potential therapeutic option for psychosis as well. Meta-analyses support the adjunctive use of zinc in major depression and a single study now supports zinc for psychotic symptoms. This manuscript reviews the biochemistry and bench top evidence on putative molecular mechanisms of zinc as a psychiatric treatment.

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Section: Nmda Receptor Anatomy and Physiologymentioning

confidence: 99%

Section: Nmda Receptor Anatomy and Physiologymentioning

confidence: 99%

The Emerging Role for Zinc in Depression and Psychosis

et al. 2017

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“…Clinical data pointed towards potential benefits of zinc administration in depressed patients [16, 17]. Zinc supplementation was shown to be effective as an adjunct therapy [6, 7, 18] or as a stand-alone intervention [19, 20] for depression. Moreover, the intake of zinc was suggested to be among the dietary factors that may be associated with a risk for depression.…”

Section: Zincmentioning

confidence: 99%

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

et al. 2017

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Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.

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“…It is also proven, that some antidepressants can influence both the blood and brain zinc level (Siwek et al 2010; Nowak et al 2005). On the other hand, several case-control trails confirmed antidepressant activity of zinc supplementation in the depressed patients (Szewczyk et al 2011; Maserejian et al 2012; Ranjbar et al 2013; Lehto et al 2013; Siwek et al 2009; Nowak et al 2003; Salari et al 2015; LAi et al 2012). …”

Section: Introductionmentioning

confidence: 97%

“…By influencing those receptors in the specific brain areas Zn 2+ indirectly modulates synaptic plasticity, regulate neuronal signal transduction, and other processes, like memory and learning (Paoletti et al 2009; Yu et al 2013; Grabrucker 2014). Furthermore, zinc affects emotional lability, psychomotor functions, attention (Szewczyk et al 2011; Swardfager et al 2013a), irritability (Russo 2011) and other emotional, executive and cognitive functions (Szewczyk et al 2011; Maes et al 1994, 1997; Swardfager et al 2013a; McLoughlin and Hodge 1990; Narang et al 1991; Salari et al 2015). …”

Section: Introductionmentioning

confidence: 99%

The serum zinc concentration as a potential biological marker in patients with major depressive disorder

Styczeń

Sowa-Kućma²,

Siwek

et al. 2016

Metab Brain Dis

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Despite many clinical trials assessing the role of zinc in major depressive disorder (MDD), the conclusions still remain ambiguous. The aim of the present clinical study was to determine and comparison the zinc concentration in the blood of MDD patients (active stage or remission) and healthy volunteers (controls), as well as to discuss its potential clinical usefulness as a biomarker of the disease. In this study 69 patients with current depressive episode, 45 patients in remission and 50 controls were enrolled. The zinc concentration was measured by electrothermal atomic absorption spectrometry (ET AAS). The obtained results revealed, that the zinc concentration in depressed phase were statistically lower than in the healthy volunteers [0.89 vs. 1.06 mg/L, respectively], while the zinc level in patients achieve remission was not significantly different from the controls [1.07 vs. 1.06 mg/L, respectively]. Additionally, among the patients achieve remission a significant differences in zinc concentration between group with and without presence of drug-resistance in the previous episode of depression were observed. Also, patients in remission demonstrated correlation between zinc level and the average number of depressive episodes in the last year. Serum zinc concentration was not dependent on atypical features of depression, presence of psychotic symptoms or melancholic syndrome, age, age of onset or duration of disease, number of episodes in the life time, duration of the episode/remission and severity of depression measured by the Hamilton Rating Scale for Depression (HDRS), and the Montgomery-Asberg Depression Rating Scale (MADRS). Concluding, our findings confirm the correlation between zinc deficit present in the depressive episode, and are consistent with the majority of previous studies. These results may also indicate that serum zinc concentration might be considered as a potential biological marker of MDD.

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Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial

Abstract: Therefore, the zinc supplementation is an appropriate choice for the depression management in patients with MS.

Cited by 39 publications

References 20 publications

The Emerging Role for Zinc in Depression and Psychosis

The Emerging Role for Zinc in Depression and Psychosis

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

The serum zinc concentration as a potential biological marker in patients with major depressive disorder

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