Zinc status is independently related to the bone mineral density, fracture risk assessment tool result, and bone fracture history: Results from a U.S. nationally representative survey

Wang, Weijie; Huang, Ming-Nan; Wang, Chikang; Yang, Anne Yuqing; Lin, Chien‐Yu

doi:10.1016/j.jtemb.2021.126765

Cited by 11 publications

(9 citation statements)

References 33 publications

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“…Among minerals, zinc and copper are essential cofactors for enzymes involved in bone matrix synthesis, acting to stimulate bone formation and to suppress its remodeling [ 57 ], with positive results regarding BMD [ 58 , 59 , 60 , 61 ]. Oxidative stress seems to have an influence on BMD, since ROS and free radicals are involved in osteoclastogenesis and osteoblast apoptosis [ 62 ], and nutrients such as selenium, β-carotene, vitamin E, alpha-tocopherol, and copper have antioxidant properties and may be important for bone protection against oxidative stress [ 58 , 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Nutrient Patterns and Risk of Osteopenia in Postmenopausal Women

et al. 2023

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Nutrient patterns (NPs) and the synergistic effect between nutrients have been shown to be associated with changes in bone mineral density (BMD). This study aimed to identify NPs and to associate them with BMD categories in postmenopausal women. This cross-sectional, observational, analytical study was carried out with women in menopause for at least 12 months, aged ≥50 years. Sociodemographic, lifestyle, and clinical variables were investigated. BMD was assessed using dual energy X-ray absorptiometry. A dietary assessment was conducted using a food frequency questionnaire, and three nutrient patterns (NP1, NP2, and NP3) were extracted from the principal component analysis. Multivariate logistic regression was applied to investigate the association between BMD classifications and NP consumption. A total of 124 women, aged on average, 66.8 ± 6.1 years, were evaluated. Of these, 41.9% had osteopenia and 36.3% had osteoporosis. The NP1 (OR: 6.64, [CI95%: 1.56–28.16]; p = 0.010), characterized by vitamin B12, pantothenic acid, phosphorus, riboflavin, protein (total and animal), vitamin B6, potassium, vitamin D, vitamin E, calcium, cholesterol, β-carotene, omega 3, magnesium, zinc, niacin, and selenium; and the NP2 (OR: 5.03, [CI95%: 1.25–20.32]; p = 0.023), characterized by iron, vegetable protein, thiamine, folate, fibers (soluble and insoluble), PUFA, vitamin A, vitamin K, alpha-tocopherol, copper, sodium, and retinol, was inversely associated with osteopenia. The lower consumption of NP1 and NP2 by postmenopausal women was associated with a higher risk of osteopenia, but not osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Nutrient Patterns and Risk of Osteopenia in Postmenopausal Women

et al. 2023

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“…Prevalent diseases included diabetes (yes, no) and hypertension (yes, no). The covariates were selected based on a literature review of published studies that investigated the association between nutrient intake (eg, copper, zinc, carotenoids, and vitamin E) and osteoporosis using the NHANES database 16,25–27 . Of the variables, total energy intake and supplement use were selected based on studies that examined the association between CDAI and health outcomes 14 .…”

Section: Methodsmentioning

confidence: 99%

Composite dietary antioxidant intake and osteoporosis likelihood in premenopausal and postmenopausal women: a population-based study in the United States

Zhang

Wei

et al. 2023

Menopause

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Objective: Osteoporosis is a skeletal disease characterized by low bone mass, reduced bone strength, and increased fracture risk. We aimed to investigate the association between combined dietary antioxidant intake and the likelihood of osteoporosis in premenopausal and postmenopausal women, based on data from the National Health and Nutrition Examination Survey.Methods: Nutrient intake data were obtained using two 24-hour recalls. Composite dietary antioxidant index (CDAI), which refers to the intake amounts of β-carotene, vitamin A, vitamin C, vitamin E, selenium, zinc, copper, and iron, was then constructed. Prevalent osteoporosis was defined according to bone mineral density T scores of ≤ −2.5 and self-reports. Multiple logistic and Poisson regression models were used for association analyses.Results: A total of 3,418 participants (1,157 premenopausal and 2,261 postmenopausal women) 40 years or older were included, 776 (22.70%) of whom had prevalent osteoporosis. In terms of individual nutrients, postmenopausal women in the highest CDAI quartiles for dietary β-carotene, vitamin A, vitamin C, and iron intakes had a low likelihood of osteoporosis. Regarding the CDAI-osteoporosis association, postmenopausal women in the highest quartile were less likely to have osteoporosis (OR Q3vsQ1 , 0.64; 95% CI, 0.43-0.96; OR Q4vsQ1 , 0.56; 95% CI, 0.35-0.89; P for trend = 0.013), after controlling for covariates.Conclusions: CDAI was negatively associated with the likelihood of osteoporosis in postmenopausal women. Our findings suggest that the combined intake of antioxidant nutrients can help reduce the likelihood of osteoporosis in women.

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“…In some previous clinical studies, higher zinc was found to be closely associated with higher bone mineral density. 8 In disuse osteoporosis, decreased physical activity was the most direct cause. Previous studies found that decreased zinc probably affected the skeletal muscle oxidative capacity, and then force production was inhibited.…”

Section: Causal Relationships In Zinc and Immunity Mechanisms With Di...mentioning

confidence: 99%

“…7 An epidemiology study focusing on serum zinc and bone fractures demonstrated that zinc was positively correlated with increased bone mineral density and decreased risk of bone fracture. 8 Zinc can increase bone mass by stimulating osteoblastic bone formation 9 and suppressing osteoclastic bone resorption. The supplementation of zinc has been demonstrated not only to help prevent and reduce bone loss in osteoporosis but also to be beneficial to fracture healing.…”

Section: Introductionmentioning

confidence: 99%

“…Osteoporotic patients have been proven to have lower levels of skeletal zinc than healthy individuals 7 . An epidemiology study focusing on serum zinc and bone fractures demonstrated that zinc was positively correlated with increased bone mineral density and decreased risk of bone fracture 8 . Zinc can increase bone mass by stimulating osteoblastic bone formation 9 and suppressing osteoclastic bone resorption.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Zinc and Stromal Immunity in Disuse Osteoporosis: Mendelian Randomization and Transcriptomic Analysis

Lyu,

Wang,

Jia

et al. 2023

Orthopaedic Surgery

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ObjectiveDisuse osteoporosis is known to be primarily caused by a lack of exercise. However, the causal relationships between zinc and immunity and disuse osteoporosis remain unknown. This study investigated these relationships and their potential mechanisms.MethodsThis study was an integrative study combining genome‐wide association studies and transcriptomics. Two‐sample Mendelian randomization analysis (MR) was used to analyze the causal relationships between exposures (zinc, immunity, physical activity) and the outcome (osteoporosis) with the aid of single‐nucleotide polymorphisms (SNPs) as instrumental variables (IVs). Four models, MR‐Egger, inverse variance weighted, weighted median and MR‐Pleiotrophy RESidual Sum and Outlier (MRPRESSO), were used to calculate odds ratio values. Sensitivity and heterogeneity analyses were also performed using MRPRESSO and MR‐Egger methods. The mRNA transcriptomic analysis was subsequently conducted. Zinc metabolism scores were acquired through single‐sample Gene Set Enrichment Analysis algorithms. Stromal scores were obtained using the R Package “estimate” algorithms. Important Kyoto Encyclopedia of Genes and Genomes and Gene Ontology pathways were also derived through gene set variation analysis. Cytoscape software helped construct the transcription factor (TF)–mRNA–microRNA (miRNA) network. Virtual screening and molecular docking were performed. Polymerase chain reaction validation was also carried out in vivo.ResultsCausal relationships were demonstrated between zinc and exercise (95% confidence interval [CI] = 1.30–2.95, p = 0.001), exercise and immunity (95% CI = 0.36–0.80, p = 0.002), exercise and osteoporosis (95% CI = 0.97–0.99, p = 0.0007), and immunity disorder and osteoporosis (95% CI = 1.30–2.03, p = 0.00002). One hundred and seventy‐nine mRNAs in important modules were screened. Combining the differential expressional genes (DEGs) and the Boruta selection, six DEGs were screened (AHNAK, CSF2, ADAMTS12, SRA1, RUNX2, and SLC39A14). TF HOXC10 and miRNA hsa‐miR‐204 were predicted. Then, the TF–mRNA–miRNA network was successfully constructed. RUNX2 and SLC39A14 were identified as hub mRNAs in the TF–mRNA–miRNA network. Eventually, the novel small drug C6O4NH5 was designed according to the pharmacophore structure of SLC39A14. The docking energy for the novel drug was −5.83 kcal/mol. SLC39A14 and RUNX2 were downregulated (of statistical significance p‐value < 0.05) in our animal experiment.ConclusionThis study revealed that zinc had a protective causal relationship with disuse osteoporosis by promoting exercise and immunity. SLC39A14 and RUNX2 mRNA participated in this zinc‐related mechanism.

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Zinc status is independently related to the bone mineral density, fracture risk assessment tool result, and bone fracture history: Results from a U.S. nationally representative survey

Cited by 11 publications

References 33 publications

Nutrient Patterns and Risk of Osteopenia in Postmenopausal Women

Nutrient Patterns and Risk of Osteopenia in Postmenopausal Women

Composite dietary antioxidant intake and osteoporosis likelihood in premenopausal and postmenopausal women: a population-based study in the United States

Analysis of Zinc and Stromal Immunity in Disuse Osteoporosis: Mendelian Randomization and Transcriptomic Analysis

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