Zinc Status and Immune System Relationship

Salgueiro, M.; Zubillaga, Marcela; Lysionek, Alexis; Cremaschi, Graciela; Goldman, Cinthia G.; Caro, R.A.; Paoli, T. De; Hager, A; Weill, R; Boccio, José

doi:10.1385/bter:76:3:193

Cited by 78 publications

(50 citation statements)

References 41 publications

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“…Zn content of the prostate gland, the seminal fluid and ejaculated sperm are very high and testicular Zn is essential for spermatogenesis. Zn deficiency has also been reported to be a cause of hypogonadism [83]. Abbreviation: DMT-1= divalent metal transporter, Fpn1= ferroportin-1, TFR1= transferrin reseptor-1, TFR2= transferrin reseptor-2.…”

Section: Zinc (Zn)mentioning

confidence: 99%

Study of Serum Copper and Iron in Children with Chronic Liver Diseases

Ibrahim¹

2013

Anat Physiol

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Trace elements have a major role as both oxidants and antioxidants, promoting and protecting from tissue damage respectively. As the liver has a pivotal role in trace elements metabolism and consequenyly their bioavailability, we aimed to measure serum levels of essential trace elements in children with chronic liver diseases (CLDs) regardless the etiology and to study their correlation with liver function tests. Serum zinc (Zn), copper (Cu) and iron (Fe); together with other trace elements parameters; were measured in 50 children with CLDs using spectrophotometry and their levels were compared with those age and sex matched healthy children as controls. Serum Cu, Fe, ferritin and transferrin saturation (TS) were significantly higher in the CLDs group than that in the control group; while serum Zn and total iron binding capacity (TIBC) were significantly lower in the CLDs than that in the control group. Serum Fe, Cu, TS and ferritin were positively correlated with biochemical parameters of liver damage; while serum Zn and TIBC were negatively correlated with biochemical parameters of liver damage. These results encourage inclusion of serum Zn, Cu and Fe as biomarkers for monitoring the severity of liver damage during routine assessment of children with CLDs. We recommended caution to avoid excess Fe and Cu intake in children with CLDs. Moreover, Zn supplementation could be encouraged in children with CLDs regardless its etiology.

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Section: Zinc (Zn)mentioning

confidence: 99%

Study of Serum Copper and Iron in Children with Chronic Liver Diseases

Ibrahim¹

2013

Anat Physiol

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“…Zn and Hg also exert a critical influence on the mammalian immune system (Salgueiro et al 2000, Rink & Gabriel 2001.…”

Section: Toxicologymentioning

confidence: 99%

Ecological and pathological factors related to trace metal concentrations in harbour porpoises Phocoena phocoena from the North Sea and adjacent areas

Das¹,

Siebert²,

Fontaine

et al. 2004

Mar. Ecol. Prog. Ser.

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“…Zinc is a trace element involved in numerous enzymatic reactions, biochemical functions, and immune responses (3,4) and is, therefore, required for growth and cellular function. The results from meta-analyses and pooled analyses of multiple highquality worldwide intervention studies have shown that the impairment of zinc absorption alone contributes substantially to growth failure (5).…”

Section: CDmentioning

confidence: 99%

Zinc homeostasis and gut function in children with celiac disease

Tran¹,

Katsikeros²,

Manton³

et al. 2011

The American Journal of Clinical Nutrition

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Background: Celiac disease (CD) is an immunologic enteropathy triggered by the intake of gluten. It is thought that the enteropathy impairs gut function and absorption. Objective: We assessed the zinc-absorption capacity and smallbowel integrity in children with CD. Design: Children in whom a diagnosis of CD was considered clinically and either confirmed (n = 16; Marsh score 3) or not (n = 22; Marsh score of 0) with a small-bowel biopsy (SBB) were recruited. The fractional absorption of zinc (FAZ) was determined by the administration of an oral 67 Zn dose (2.5 mg) and an intravenous 70 Zn dose (0.2 mg) 2 h before and during the SBB, respectively. Spot urine samples were collected, and zinc isotopic ratios were determined by ion-coupled plasma mass spectrometry. Gut health was assessed by the ingestion of 13 C-sucrose (20 g) after an overnight fast, and breath samples were collected and analyzed by isotope ratio mass spectrometry. Results: There was no difference in FAZ between children with a Marsh score 3 (mean 6 SEM: 0.68 6 0.05) and children with a Marsh score of 0 (0.74 6 0.05). The exchangeable zinc pool (EZP) was significantly (P , 0.05) lower in children with a Marsh score 3 (2.6 6 0.8 mg/kg) than in children with a Marsh score of 0 (3.8 6 1.4 mg/kg). Gut function in children with a Marsh score 3 (4.5 6 0.7% cumulative dose recovered at 90 min) was lower than the lower cutoff of a normal gut-function breath test (5.06% cumulative dose recovered at 90 min) but not significantly different from that in children with a Marsh score of 0 (4.9 6 0.4%). There was a significant (P , 0.01) correlation between zinc absorption and gut function in children with CD. Conclusions: Zinc absorption did not appear below usual amounts in subjects with CD. Children with CD have impaired gut function that may affect their zinc nutritional status as shown by a smaller EZP. However, the EZP decrease in children with CD was not compared with that in healthy control subjects, and its biological meaning is uncertain.Am J Clin Nutr 2011;94:1026-32.

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Zinc Status and Immune System Relationship

Cited by 78 publications

References 41 publications

Study of Serum Copper and Iron in Children with Chronic Liver Diseases

Study of Serum Copper and Iron in Children with Chronic Liver Diseases

Ecological and pathological factors related to trace metal concentrations in harbour porpoises Phocoena phocoena from the North Sea and adjacent areas

Zinc homeostasis and gut function in children with celiac disease

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