Zinc-selenium interaction in the rat

Chmielnicka, Jadwiga; Zaręba, Grażyna; Witasik, M.; Brzeźnicka, E A

doi:10.1007/bf02990143

Cited by 23 publications

(7 citation statements)

References 18 publications

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“…Element contents in whole blood of rats according to the increasing defatted rapeseeds (DRS) rate (mg/kg of dry matter) in the diet (2014) concluded that dietary Se had no effect on Zn levels in rats and chicken. Chmielnicka et al (1988) observed increasing Zn content in rats exposed to single-dose applied inorganic Se. These findings indicate that the potential effect of Se on the other essential elements depends on many factors such as animal species, Se dose, Se species applied, single vs long-term Se application etc.…”

Section: Resultsmentioning

confidence: 82%

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Myška¹,

Száková²,

Fučíková³

et al. 2016

CZECH J ANIM SCI

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ABSTRACT:The effect of selenium-enriched defatted rapeseeds (DRS) added to the diet on Se uptake by rat organisms (whole blood, liver, kidney) was investigated in model conditions. Additionally, the response of other essential trace and major mineral elements (Cu, Ca, Fe, K, Mg, Mn, P, S, and Zn) in rat organisms on selenium and/or DRS addition was assessed. The experimental diets for the individual experimental groups were prepared as follows: group DRS 0 (control diet), group DRS 30 (30% of soybean meal in the diet replaced with DRS), group DRS60 (60% of soybean meal in the diet replaced with DRS), and group DRS100 (100% of soybean meal in the diet replaced with DRS), either unenriched or naturally fortified with Se. Whereas Se content in the blood and liver of the animals remained unchanged, increased Se levels were observed in kidney of the selenized DRS100 group compared to the others. Moreover, the results showed decreasing Cd content in the rat liver with increasing Se content in the diet, confirming antagonism of these elements. Concerning the essential elements, the application of the selenized DRS did not result in any serious imbalance in the utilization of these elements. In contrast, Se addition seems to be helpful for the improved utilization of essential elements such as P, S, and Zn, compared to the DRS-containing diet without Se fortification.

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Section: Resultsmentioning

confidence: 82%

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Myška¹,

Száková²,

Fučíková³

et al. 2016

CZECH J ANIM SCI

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“…Zn-Se was highly significantly correlated in urine and feces. The effects of the Zn-Se interaction were described in a previous animal experiment in which administration of Zn induced a decrease in urinary Se excretion, whereas a visible decrease in fecal Zn excretion was observed in the presence of Se [11]. The mechanisms of these interactions are not known.…”

Section: Zincmentioning

confidence: 84%

Correlations of Trace Element Levels in the Diet, Blood, Urine, and Feces in the Chinese Male

Wang

Liu

et al. 2011

Biol Trace Elem Res

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In order to explore the associations between trace elements in dietary intake and the other three biological media (blood, urine, or feces) and inter-element interactions among the latter, we simultaneously collected 72-h diet duplicates, whole blood, and 72-h urine and feces from 120 free-living healthy males in China. Correlations among the toxic (cadmium [Cd], lead [Pb]), and nutritionally essential (zinc [Zn], copper [Cu], iron [Fe], manganese [Mn], selenium [Se], iodine [I]) elements were evaluated using Spearman rank correlation analysis based on analytical data determined by inductively coupled plasma-mass spectrometry. Dietary Cd intakes were highly correlated with the fecal Cd and blood Cd levels. Inverse correlations were found for Fe-Cd and Fe-Pb in both diet versus blood and diet versus feces. Cd-Zn and Cd-Se were significantly directly correlated in the urine and feces. Cd-Se and Pb-Se were negatively correlated in blood. In addition, there existed an extremely significant association between urinary Se and urinary I. Moreover, the other two highly direct correlations were found for Se-Fe and for I-Fe in urine. Improved knowledge regarding their mutual associations is considered to be of fundamental importance to understand more the complex interrelationships in trace element metabolism.

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“…In particular, it has been shown that zinc supplementation in dialysis patients increases serum selenium concentration (Guo et al, 2013). A simultaneous administration of selenium and zinc resulted in enhanced trace elements retention in organs and tissues (Chmielnicka et al, 1988). Moreover, selenium supplementation has also been shown to increase tissue selenium in animals fed both zinc-adequate and zinc-defi cient diet (Fatmi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…However, zinc administration decreased selenium retention only at higher zinc:selenium ratio (10:1) whereas no antagonism was observed at a 2:1 ratio (Eybl et al, 1986). At the same time, Chmielnicka and the coauthors have demonstrated lower urinary selenium excretion after zinc treatment (Chmielnicka et al, 1988).…”

mentioning

confidence: 98%

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Skalny

Tinkov

Medvedeva

et al. 2015

Acta Sci Pol Technol Aliment

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Background.A signifi cant association between Zn and Se homeostasis exists. At the same time, data on the infl uence of zinc supplementation on selenium distribution in organs and tissues seem to be absent. Therefore, the primary objective of the current study is to investigate the infl uence of zinc asparaginate supplementation on zinc and selenium distribution and serum superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in Wistar rats. Material and methods. 36 rats were used in the experiment. The duration of the experiment was 7 and 14 days in the fi rst and second series, respectively. The rats in Group I were used as the control ones. Animals in Groups II and III daily obtained zinc asparaginate (ZnA) in the doses of 5 and 15 mg/kg weight, respectively. Zinc and selenium content in liver, kidneys, heart, muscle, serum and hair was assessed using inductively coupled plasma mass spectrometry. Serum SOD and GPx activity was analysed spectrophotometrically using Randox kits. Results. Intragastric administration of zinc asparaginate signifi cantly increased liver, kidney, and serum zinc content without affecting skeletal and cardiac muscle levels. Zinc supplementation also stimulated selenium retention in the rats' organs. Moreover, a signifi cant positive correlation between zinc and selenium content was observed. Finally, zinc asparaginate treatment has been shown to modulate serum GPx but not SOD activity. Conclusion. The obtained data indicate that zinc-induced increase in GPx activity may be mediated through modulation of selenium status. However, future studies are required to estimate the exact mechanisms of zinc and selenium interplay.

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Zinc-selenium interaction in the rat

Cited by 23 publications

References 18 publications

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Correlations of Trace Element Levels in the Diet, Blood, Urine, and Feces in the Chinese Male

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

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