Zinc(<scp>ii</scp>), copper(<scp>ii</scp>) and cadmium(<scp>ii</scp>) complexes as fluorescent chemosensors for cations

Pandey, Rampal; Kumar, Ashish; Xu, Qiang; Pandey, Daya Shankar

doi:10.1039/c9dt03017d

Cited by 54 publications

(40 citation statements)

References 110 publications

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“…This was attributed to the ion-induced coordinate self-assembly of AuLA-GSH. 40,41 When changing the pH values of these mixtures from 7.4 to 6.0, the fluorescence intensities of AuLA-GSH-Co and AuLA-GSH-Ni recovered by ~30%, while the fluorescence intensity of AuLA-GSH-Cu did not change (Figure 3B, S3). This was due to the fact that the strength of coordination bonds between Cu 2+ ions and residues in AuLA-GSH was more robust than those of Co 2+ and Ni 2+ ions, which would not be influenced by pH.…”

Section: Fluorescence Switch Features and Co 2+mentioning

confidence: 99%

<p>A pH-Responsive System Based on Fluorescence Enhanced Gold Nanoparticles for Renal Targeting Drug Delivery and Fibrosis Therapy</p>

Lai

Geng

Tan

et al. 2020

IJN

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Background Stimuli-responsive gold nano-assemblies have attracted attention as drug delivery systems in the biomedical field. However, there are challenges achieving targeted delivery and controllable drug release for specific diseases. Materials and Methods In this study, a glutathione (GSH)-modified fluorescent gold nanoparticle termed AuLA-GSH was prepared and a Co 2+ -induced self-assembly drug delivery platform termed AuLA-GSH-Co was constructed. Both the pH-responsive character and drug loading behavior of AuLA-GSH-Co were studied in vitro. Kidney-targeting capability was investigated in vitro and in vivo. Finally, the anti-fibrosis efficiency of AuLA-GSH-Co in a mouse model of unilateral ureteral obstruction (UUO) was explored. Results AuLA-GSH-Co was sensitive to pH changes and released Co 2+ in acidic conditions, allowing it to have controllable drug release abilities. AuLA-GSH-Co was found to improve cellular uptake of Co 2+ ions compared to CoCl 2 in vitro. AuLA-GSH exhibited specific renal targeting and prolonged renal retention time with low non-specific accumulation in vivo. Moreover, the anti-fibrosis efficiency of AuLA-GSH-Co was higher compared to CoCl 2 in a mouse model of unilateral ureteral obstruction (UUO). Conclusion AuLA-GSH-Co could greatly enhance drug delivery efficiency with renal targeting capability and obviously relieve renal fibrosis, providing a promising strategy for renal fibrosis therapy.

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Section: Fluorescence Switch Features and Co 2+mentioning

confidence: 99%

<p>A pH-Responsive System Based on Fluorescence Enhanced Gold Nanoparticles for Renal Targeting Drug Delivery and Fibrosis Therapy</p>

Lai

Geng

Tan

et al. 2020

IJN

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“…Zinc(II) can coordinate with a vast number of N and N, O donor molecules, displaying interesting luminescent properties for LED devices and sensors. 141 Regarding the Zn(II) metallomesogens reported in the literature, they have shown variable coordination geometries such as square planar with porphyrin ligands or trigonalbipyramidal with ligands such as dithiobenzoates and tridentate pyridines. Nevertheless, tetrahedral or octahedral zinc complexes with mesomorphic properties have continued a hedged objective for a long time.…”

Section: Molecular Architectures Based On Zn(ii)mentioning

confidence: 99%

Advanced Functional Luminescent Metallomesogens: The Key Role of the Metal Center

2021

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The use of liquid crystals for the fabrication of displays incorporated in technological devices (TVs, calculators, screens of eBook’s, tablets, watches) demonstrates the relevance that these materials have had in our way of living. However, society evolves, and improved devices are looked for as we create a more efficient and safe technology. In this context, metallomesogens can behave as multifunctional materials because they can combine the fluidic state of the mesophases with properties such as photo and electroluminescence, which offers new exciting possibilities in the field of optoelectronics, energy, environment, and even biomedicine. Herein, it has been established the role of the molecular geometry induced by the metal center in metallomesogens to achieve the self-assembly required in the liquid-crystalline mesophase. Likewise, the effect of the coordination environment in metallomesogens has been further analyzed because of its importance to induce mesomorphism. The structural analysis has been combined with an in-depth discussion of the properties of these materials, including their current and potential future applications. This review will provide a solid background to stimulate the development of novel and attractive metallomesogens that allow designing improved optoelectronic and microelectronic components. Additionally, nanoscience and nanotechnology could be used as a tool to approach the design of nanosystems based on luminescent metallomesogens for use in bioimaging or drug delivery.

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“…Fluorescence chemosensing possesses the advantages of simplicity, rapid responsivity, and high sensitivity. − Nanomaterials have been demonstrated as excellent photoluminescence platforms for biomedical applications. , Charge transfer between nanoparticles and molecules attached to their surface can alter the emission behavior of the nanoparticles, which is the principle of charge transfer-based biosensing. , Dopamine (DA), a neurotransmitter responsible for transmitting neurosignals in usual movements, has been widely reported as an effective electron acceptor. − Current studies in this area have mostly focused on quantum dots (QDs), that is, the formation of QD–DA biosensors that operate based on the high sensitivity of QDs to charge transfer processes. ,,− In these QD–DA bioconjugates, DA is first covalently bonded with a linker (peptide or CS 2 ) though the amine group and then used to modify the surface of QDs through a coupling reaction. , However, this tedious bioconjugation process and the high toxicity of QDs have greatly restricted the use of QD–DA bioconjugates in practical biosensing.…”

Section: Introductionmentioning

confidence: 99%

Dopamine-Modified AuCu Bimetallic Nanoclusters as Charge Transfer-Based Biosensors for Highly Sensitive Glycine Detection

Chen

Ding

et al. 2020

Langmuir

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Glycine is the simplest amino acid in living organisms and plays important roles in biology and medicine. However, few biosensors for glycine sensing have been reported. Herein, we present a facile strategy to construct dopaminemodified AuCu bimetallic nanoclusters (denoted as AuCu NC− DA) as charge transfer-based biosensors for highly sensitive glycine sensing. The AuCu NCs stabilized by bovine serum albumin (BSA) exhibited a fluorescence maximum at 400 nm. Because of the high affinity of BSA for dopamine (DA), the surface of the AuCu NCs was modified with DA without any complicated chemical reactions, resulting in fluorescence quenching through a charge transfer process. Among 20 amino acids, AuCu NC−DA exhibited an off/on fluorescence switching response specifically toward glycine through the formation of hydrogen bonds with oxidized DA, which inhibited the charge transfer process, leading to the emergence of a new emission peak at 475 nm. Spectroscopic and thermodynamic results combined with molecular docking analyses provided comprehensive understanding of the sensing mechanism. Furthermore, we showed that AuCu NC−DA was able to sense glycine in cells by imaging. Finally, the practicability of AuCu NC−DA for glycine detection was validated in milk drink samples. This study presents a promising type of a charge transfer-based sensor.

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Zinc(ii), copper(ii) and cadmium(ii) complexes as fluorescent chemosensors for cations

Abstract: Fluorescence chemosensing behavior of Zn(ii), Cu(ii), and Cd(ii) complexes for detection of cations emphasizing conventional, metal–metal exchange and chemodosimetric mechanisms has been described conferring their scope, significance and challenges.

Cited by 54 publications

References 110 publications

<p>A pH-Responsive System Based on Fluorescence Enhanced Gold Nanoparticles for Renal Targeting Drug Delivery and Fibrosis Therapy</p>

<p>A pH-Responsive System Based on Fluorescence Enhanced Gold Nanoparticles for Renal Targeting Drug Delivery and Fibrosis Therapy</p>

Advanced Functional Luminescent Metallomesogens: The Key Role of the Metal Center

Dopamine-Modified AuCu Bimetallic Nanoclusters as Charge Transfer-Based Biosensors for Highly Sensitive Glycine Detection

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