Zinc-Related Magnetic Isotope Effect in the Enzymatic ATP Synthesis: A Medicinal Potential of the Nuclear Spin Selectivity Phenomena

Бучаченко, А. Л.; Чехонин, В. П.; Орлов, А. А.; Kuznetsov, Dmitry A.

doi:10.3923/ijmmas.2010.34.37

Cited by 26 publications

(17 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently this ion-radical mechanism was shown to function in the ATP synthesis . HO catalyzed by Zn 2+ ions [23]. This universal mechanism is supposed to be promising in biomedical applications as was mentioned in the Section 1.…”

Section: Resultsmentioning

confidence: 96%

Calcium induced ATP synthesis: Isotope effect, magnetic parameters and mechanism

Бучаченко¹,

Kuznetsov²,

Breslavskaya³

et al. 2011

Chemical Physics Letters

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 96%

Calcium induced ATP synthesis: Isotope effect, magnetic parameters and mechanism

Бучаченко¹,

Kuznetsov²,

Breslavskaya³

et al. 2011

Chemical Physics Letters

View full text Add to dashboard Cite

“…The rates of ATP synthesis by CK in mitochondria as a function of zinc isotopes: 64 ZnCl 2 (1) and 67 ZnCl 2 (2). A is the radioactivity of ATP (in scintillations/min/mg of protein) [Buchachenko et al, 2010c]. spin state; magnetic field stimulates singlet-triplet spin conversion and switches on a new, triplet channel of phosphorylation.…”

Section: Magnetic Control Of the Atp Synthesismentioning

confidence: 99%

“…Enzymatic activity of mitochondrial CK with 67 Zn 2+ ions (magnetic nucleus 67 Zn) is also markedly increased with respect to that of CK with nonmagnetic isotope 64 Zn 2+ ions (Fig. ) [Buchachenko et al, ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Why magnetic and electromagnetic effects in biology are irreproducible and contradictory?

Бучаченко

2015

Bioelectromagnetics

View full text Add to dashboard Cite

The main source of magnetic and electromagnetic effects in biological systems is now generally accepted and demonstrated in this paper to be radical pair mechanism which implies pairwise generation of radicals in biochemical reactions. This mechanism was convincingly established for enzymatic adenosine triphosphate (ATP) and desoxynucleic acid (DNA) synthesis by using catalyzing metal ions with magnetic nuclei ((25)Mg, (43)Ca, (67)Zn) and supported by magnetic field effects on these reactions. The mechanism, is shown to function in medicine as a medical remedy or technology (trans-cranial magnetic stimulation, nuclear magnetic control of the ATP synthesis in heart muscle, the killing of cancer cells by suppression of DNA synthesis). However, the majority of magnetic effects in biology remain to be irreproducible, contradictory, and enigmatic. Three sources of such a state are shown in this paper to be: the presence of paramagnetic metal ions as a component of enzymatic site or as an impurity in an uncontrollable amount; the property of the radical pair mechanism to function at a rather high concentration of catalyzing metal ions, when at least two ions enter into the catalytic site; and the kinetic restrictions, which imply compatibility of chemical and spin dynamics in radical pair. It is important to keep in mind these factors to properly understand and predict magnetic effects in magneto-biology and biology itself and deliberately use them in medicine.

show abstract

“…Opening the magnetic isotope effect on ATP synthesis magnetic isotope magnesium 25 Mg 2+ [4][5][6], also for 67 Zn 2+ [7] and 43 Ca 2+ [8] showed that the rate of enzymatic reaction depends on the presence of the nuclear magnetic moment of the metal ion in the active phosphorylation site of the enzyme. Until the discovery of magnetic isotope effects in biochemistry [4] in the enzymatic phosphorylationthe possible influence of magnetic isotopes on living organisms is not expected.…”

Section: Resultsmentioning

confidence: 99%

Neutron (Magnetic Isotope) Catalysis for Example Isotopes 24,25,26Mg in Cells E. Coli

Zhakenovich¹,

Valentina²,

Nessipbay³

et al. 2015

JCCE

View full text Add to dashboard Cite

show abstract

Zinc-Related Magnetic Isotope Effect in the Enzymatic ATP Synthesis: A Medicinal Potential of the Nuclear Spin Selectivity Phenomena

Cited by 26 publications

References 11 publications

Calcium induced ATP synthesis: Isotope effect, magnetic parameters and mechanism

Calcium induced ATP synthesis: Isotope effect, magnetic parameters and mechanism

Why magnetic and electromagnetic effects in biology are irreproducible and contradictory?

Neutron (Magnetic Isotope) Catalysis for Example Isotopes 24,25,26Mg in Cells E. Coli

Contact Info

Product

Resources

About