Zinc protection in fetal rats for maternal mercury exposure‐induced growth retardation is probably associated with S100B expression

Weng, Zhanping; Liu, Zonghua; Zhang, Shuping; Hong, Tao; Ji, Xianghong

doi:10.1111/jog.13175

Cited by 9 publications

(5 citation statements)

References 22 publications

(37 reference statements)

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“…S100a6 is known to be upregulated under conditions of oxidative stress [39]. S100b has been associated with the protective effects of nutritional zinc against methyl mercury exposure [40], as well as linked to MT2 expression in bipolar mood disorder [41]. Additional studies are underway in our laboratories to further explore the molecular mechanisms that link this differential expression of MT2 / S100b and MT3 / S100A6 .…”

Section: Discussionmentioning

confidence: 99%

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

Bousleiman

Pinsky

et al. 2017

IJMS

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A study of factors proposed to affect metallothionein-3 (MT3) function was carried out to elucidate the opaque role MT3 plays in human metalloneurochemistry. Gene expression of Mt2 and Mt3 was examined in tissues extracted from the dentate gyrus of mouse brains and in human neuronal cell cultures. The whole-genome gene expression analysis identified significant variations in the mRNA levels of genes associated with zinc homeostasis, including Mt2 and Mt3. Mt3 was found to be the most differentially expressed gene in the identified groups, pointing to the existence of a factor, not yet identified, that differentially controls Mt3 expression. To examine the expression of the human metallothioneins in neurons, mRNA levels of MT3 and MT2 were compared in BE(2)C and SH-SY5Y cell cultures treated with lead, zinc, cobalt, and lithium. MT2 was highly upregulated by Zn2+ in both cell cultures, while MT3 was not affected, and no other metal had an effect on either MT2 or MT3.

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Section: Discussionmentioning

confidence: 99%

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

Bousleiman

Pinsky

et al. 2017

IJMS

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“…Other risk factors are multiple pregnancy, primiparity, maternal malnutrition, and low socioeconomic status. Zinc sulfate feeding, of mercury-exposed pregnant rats, could correct the reduced placental weight, fetal weight and size, and tail length induced by mercury exposure [8]. SGA is associated with a four-fold increased risk of stillbirth as well as higher rates of cesarean and induced labor before 37 weeks [9][10][11].…”

Section: Etiology Risk Factors and Diagnostic Measuresmentioning

confidence: 99%

Intrauterine Growth Restriction

Haroun¹

2017

APBIJ

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Intrauterine growth restriction (IUGR) is considered the most common cause of low birth weight or small for gestational age (SGA) birth. When the maternal environment during pregnancy is perturbed, from events such as hypoxia, stress, toxins, inflammation, and placental hypo perfusion, impaired fetal development will result. The main underlying mechanism of IUGR is chronic placental insufficiency that interrupts oxygen and nutrients supply to the fetus resulting in an abnormal fetal growth; the placenta shows functional and structural changes. IUGR is either symmetrical or asymmetrical. It is a major cause of perinatal morbidity and mortality. The condition is frequently associated with neurodevelopment, metabolic and cardiovascular impairments early in infancy and late in adulthood.

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“…S100B is a calcium-binding protein that also contains EF-hand and can bind Ca, Zn [42], Cd [43], Mg, and K [44]. A study in Atlantic sharpnose sharks (Rhizoprionodon terraenovae) showed that brain Hg levels positively correlated with CSF S100B levels [45], while rats prenatally exposed to Hg had a significant increase in S100B expression (the effect was reversed with Zn treatment; [46]). Studies in humans showed that children with acute Hg intoxication had significantly increased serum S100B levels [47], while individuals chronically exposed to Hg had an increase in mRNA S100B expression [48].…”

Section: Discussionmentioning

confidence: 99%

Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

Leko

Mihelčić

Jurasović

et al. 2022

IJMS

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Various metals have been associated with the pathogenesis of Alzheimer’s disease (AD), principally heavy metals that are environmental pollutants (such as As, Cd, Hg, and Pb) and essential metals whose homeostasis is disturbed in AD (such as Cu, Fe, and Zn). Although there is evidence of the involvement of these metals in AD, further research is needed on their mechanisms of toxicity. To further assess the involvement of heavy and essential metals in AD pathogenesis, we compared cerebrospinal fluid (CSF) AD biomarkers to macro- and microelements measured in CSF and plasma. We tested if macro- and microelements’ concentrations (heavy metals (As, Cd, Hg, Ni, Pb, and Tl), essential metals (Na, Mg, K, Ca, Fe, Co, Mn, Cu, Zn, and Mo), essential non-metals (B, P, S, and Se), and other non-essential metals (Al, Ba, Li, and Sr)) are associated with CSF AD biomarkers that reflect pathological changes in the AD brain (amyloid β1–42, total tau, phosphorylated tau isoforms, NFL, S100B, VILIP-1, YKL-40, PAPP-A, and albumin). We used inductively coupled plasma mass spectroscopy (ICP-MS) to determine macro- and microelements in CSF and plasma, and enzyme-linked immunosorbent assays (ELISA) to determine protein biomarkers of AD in CSF. This study included 193 participants (124 with AD, 50 with mild cognitive impairment, and 19 healthy controls). Simple correlation, as well as machine learning algorithms (redescription mining and principal component analysis (PCA)), demonstrated that levels of heavy metals (As, Cd, Hg, Ni, Pb, and Tl), essential metals (Ca, Co, Cu, Fe, Mg, Mn, Mo, Na, K, and Zn), and essential non-metals (P, S, and Se) are positively associated with CSF phosphorylated tau isoforms, VILIP-1, S100B, NFL, and YKL-40 in AD.

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Zinc protection in fetal rats for maternal mercury exposure‐induced growth retardation is probably associated with S100B expression

Abstract: Maternal exposure to mercury results in increased S100B in the placenta. Zinc sulfate feeding could reduce S100B and mercury levels, thereby protecting the rats from mercury damage. S100B level may be used to measure the antagonism between zinc and mercury during pregnancy.

Cited by 9 publications

References 22 publications

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

Intrauterine Growth Restriction

Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

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